Friday January 24, 2020

Blocking Digestive Hormone May Prevent Pancreatic Cancer

The team explained that pancreatic growth and regeneration occurs through interaction of CCK with CCK receptors, proteins that bind to CCK to produce a physiological reaction

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5 herbs for a healthy digestive system. Pixabay

Blocking a digestive hormone associated with obesity may help prevent the spread of pancreatic tumours to other areas in the body, according to a study.

A high-fat diet promotes the growth of pancreatic cancer independent of obesity because of the interaction between dietary fat and cholecystokinin (CCK) — digestive hormone released by the small intestine. The hormone secretion gets further triggered by the fatty diet.

Previous research has shown that obesity and high-fat diets both together and independently increase the risk of pancreatic cancer.

“Most patients with advanced pancreatic cancer succumb to the disease due to metastases; therefore a compound that blocks metastases, even when the primary tumour size is large, may have clinical significance,” said the researchers including Jill Smith from the Georgetown University in the US.

“CCK [receptor] blockade may play a role in the treatment and prevention of pancreatic cancer,” they added.

Previous research has shown that obesity and high-fat diets both together and independently increase the risk of pancreatic cancer.
Previous research has shown that obesity and high-fat diets both together and independently increase the risk of pancreatic cancer. Pixabay

For the study, published in American Journal of Physiology-Gastrointestinal and Liver Physiology, the team fed one group of mice with high-fat diet while the other half were given a normal diet. Then some of them were treated with proglumide — a medication that blocks CCK.

The results showed that mice treated with proglumide had less tumour growth than the untreated mice, even when fed a high-fat diet.

Further, they found that among high-fat diet-fed mice lacking CCK receptors did not show any tumour growth, suggesting that without receptors to bind to, increased CCK from dietary fat is unable to promote cancer.

Also Read: More Women Falling Prey to Lung Cancer: Study

The team explained that pancreatic growth and regeneration occurs through interaction of CCK with CCK receptors, proteins that bind to CCK to produce a physiological reaction.

Proglumide treatment also protected the mice from the development of excessive fibrous tissue — fibrosis — that can be associated with cancer metastases and resistance to chemotherapy, the researchers said. (IANS)

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Here’s How a Low Fat Diet May Cut Pancreatic Cancer Risk

Researchers have found links between obesity and pancreatic cancer

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Pancreatic Cancer
There is a significant connection between obesity and Pancreatic Cancer. Lifetime Stock

The sound of the word ‘Cancer is enough to scare anyone because there is no definite cure for it. Pancreatic cancer is one of those cancers in which the overall survival is very bleak as cases are often less sensitive to chemotherapy and radiotherapy. Dr Pradeep Jain, GI Oncosurgery, Medical Oncology, Fortis Hospital, Shalimar Bagh informs you about the connection between obesity and Pancreatic Cancer.

The best method to decrease the mortality (death rate) of these cancers is to either catch them early or prevent them happening. In view of non-availability of any screening test and limitation of diagnostic test, it is almost impossible to catch them very early. As dietary modification has been known for a long time to prevent cancer, it is likely to work in case of pancreatic cancer also.

diet pancreatic cancer
Dietary modification has been known to cut down the risk of developing pancreatic cancer. Lifetime Stock

Pancreatic cancer is associated with obesity and fat consumption as suggested in many epidemiological studies. Consumption of fat has been linked to pancreatic cancer not only directly but also by causing obesity. In obesity there is a general increase in inflammatory conditions in the body which leads to release of some chemicals (cytokines) which have important role in creation of pancreatic cancer.

Fat consumption (mainly saturated fats) have been shown to increase cancer of the pancreas by many observational studies in last 2 decades. In fact a study published (which comprised of more than half million US adults) in journal of the National Cancer Institute in 2009 demonstrated a positive association between dietary intake of total fat, particularly from animal sources. When people taking highest of fat compared to people taking lowest of fat, they are 23 per cent more likely to be diagnosed with pancreatic cancer (the effect was more profound when intake of saturated fat was more).

It is very difficult to comment how does fat consumption lead to pancreatic cancer, but it is likely that fat stimulates the release of an important hormone CCK (Cholecystokinin) for biliary and pancreatic secretion. And this hormone is an important instrument in the growth of pancreatic cancer cells.

In fact, in an experimental study, the antagonist of CCK, Proglumide has shown to decrease the growth of cancer cells and decrease metastasis (spread) potential of cancer.

Pancreatic Cancer
Pancreatic cancer is associated with obesity and fat consumption. Lifetime Stock

Now this leads to an important question whether with diet modification (by reducing content of fat) is it possible to decrease the chances of pancreatic cancer? A recent study published in Nov 2017 issue of AICR’S cancer research update) have found that older women who are overweight or obese had lowered the risk of getting pancreatic cancer by following a low fat diet plan.

Some were arranged to eat less fat and more vegetables, fruits and grains (the intervention group) other followed their normal diet (the comparison group). After 15 years of follow up, 92 cases of pancreatic cancer were identified in the intervention group and 165 in the comparison group. This translates to a rate of 35 cases per 100,000 in the intervention group and 41 per 100,000 in the comparison group.

Low fat diet was particularly effective in reducing cancer risk in over weight and obese post-menopausal woman. A low fat diet was not found to lower the disease risk for women whose weight was normal.

Also Read- Here’s How Sugar Relates to Cancer

Though these evidences support that high fat consumption may increase the chances of pancreatic cancer and by reducing the fat consumption the incidence of cancer may decrease, but these cannot be considered as very strong evidence to support a ‘cause and effect’. But this can be considered at least a caution to decrease fat (particularly animal fat) consumption in diet.

Foods that are sources of saturated or trans fats are butter, margarine (stick), coconut oil, palm oil, vegetable oil and hydrogenated oil. We should motivate the general public to consume more of fibre and exercise and reduce saturated fat content from diet. (IANS)