Cancer research has just got a huge boost. The rejuvenated shot comes with the development of an error free and accurate test by scientists that predicts the chances of being implicated with cancer up to 13 years in the future.
The breakthrough was made by researchers at Harvard and Northwestern University, by making use of the discovery of tiny but significant changes taking place in the body, more than a decade before cancer was diagnosed.
According to the research, published in the online journal Ebiomedicine, the protective caps on the ends of chromosomes, which prevent DNA damage, were more worn down for those who went on to develop cancer.
The protective caps, better known as “telomeres”, were found to be much shorter than they should have been. They continued to get shorter and then suddenly stopped shrinking four years before the cancer developed.
Dr Lifang Hou, the lead study author, told The Telegraph, “Because we saw a strong relationship in the pattern across a wide variety of cancers, with the right testing these procedures could be used eventually to diagnose a wide variety of cancers.”
“Understanding this pattern of telomere growth may mean it can be a predictive biomarker for cancer. We found cancer has hijacked the telomere shortening in order to flourish in the body”, he further said.
Resistance to commonly-used antibiotic clarithromycin is rising among Indian patients and that too at quite a fast pace, health experts have warned.
Clarithromycin is used to treat a wide variety of bacterial infections. This medication can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers.
According to the World Health Organization (WHO), antibiotic resistance is one of the biggest threats to global health, food security and development today.
Sunil Sofat, Additional Director, Department of Interventional Cardiology (Adult) at Jaypee Hospital in Noida, said that every antibiotic medicine has its own mechanism to treat diseases.
“Yes, this is true that the resistance to clarithromycin is rising among the Indian patients and that too at quite a fast pace. There are multiple factors for the same but one of the major reasons behind it is self-medication,” Sofat told IANS.
“In India, a huge population prefers to consume over-the-counter (OTC) drugs without even consulting a doctor. In the long run, this may make them resistant to most of the antibiotics including clarithromycin,” Sofat added.
In a recent study presented at United European Gastroenterology (UEG) Week Barcelona 2019, researchers have found that resistance to clarithromycin, one of the most established antimicrobials used to eradicate Helicobacter pylori (H. pylori), had increased from 9.9 per cent in 1998 to 21.6 per cent last year, with increases in resistance also seen for levofloxacin and metronidazole.
The study, which analysed 1,232 patients from 18 countries across Europe, investigated resistance to antibiotics regularly taken for Helicobacter pylori infection, a harmful bacterium associated with gastric ulcers, lymphoma and gastric cancer.
According to Gaurav Jain, Senior Consultant, Internal Medicine at Dharamshila Narayana Superspeciality Hospital, New Delhi, antibiotic resistance is a major concern.
“In India the consumption of antibiotics without consulting a qualified physician is quite common which is leading to its resistance,” Jain told IANS.
“There is increase in resistance to antibiotics including clarithromycin which is undoubtedly a worrisome situation in the country,” Jain said.
However, Deepak Verma of Internal Medicine at Columbia Asia Hospital, Ghaziabad said: “Most of the cases that we see in India are connected to gram-negative bacteria such as e.coli that causes urinary tract infection (UTI).”
He added that the main causes for antibiotic resistance in India are its rampant misuse where people indulge in self-doctoring as well as taking medicines prescribed by unregistered medical practitioners, including quacks who suggest antibiotics quite indiscriminately.
“They primarily use antibiotics symptomatically which is not a correct method for all ailments — without blood and urine culture. Antibiotics can force the pathogen to develop resistance,” Verma explained.
“Since the clinical culture in India is different from that of the western countries, the lack of awareness of the right process to prescribe antibiotics increases the chances of people using antibiotics without questioning,” he stressed. (IANS)