Saturday January 18, 2020

Cancer May Lead to Premature Ageing, Says Study

They established that the NOX2 enzyme generates superoxide which drives the ageing process

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Cancer patient
Cancer patient.

While it is well known that ageing promotes cancer development, UK researchers have showed that the reverse is also true.

A team from the University of East Anglia (UEA) found that leukaemia — a type of blood cancer — promotes premature ageing in healthy bone marrow cells.

Importantly, the aged bone marrow cells accelerate the growth and development of the leukaemia, creating a vicious cycle that fuels the disease.

“Our results provide evidence that cancer causes ageing. We have clearly shown that the cancer cell itself drives the ageing process in the neighbouring non-cancer cells,” said Stuart Rushworth from UEA’s Norwich Medical School.

“Our research reveals that leukaemia uses this biological phenomenon to its advantage to accelerate the disease,” he added.

Cancer
Cancer Ribbon. Pixabay

The study, published on Thursday in the journal Blood, also identified the mechanism by which this process of premature ageing occurs in the bone marrow of leukaemia patients and highlights the potential impact this could have on future treatments.

The team showed NOX2, an enzyme usually involved in the body’s response to infection, to be present in acute myeloid leukaemia (AML) cells — and this was found to be responsible for creating the ageing conditions.

They established that the NOX2 enzyme generates superoxide which drives the ageing process.

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By slowing down NOX2, researchers showed the reduction in aged neighbouring non-malignant cells resulted in slower cancer growth.

Rushworth said: “It was not previously known that leukaemia induces ageing of the local non cancer environment. We hope that this biological function can be exploited in future, paving the way for new drugs.” (IANS)

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Most Advanced Radiation Therapy For Cancer Patients Arrives in India

With the most recent introduction of Radixact X9, radiation oncology has reached a new horizon in the race of effective curative treatment for cancer

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Cancer
Cancer Patients find it more comfortable to be treated under this technology owing to the rotational helical mechanism, also the set-up time is lesser as compared to other therapies. Pixabay

Indraprastha Apollo Hospital in New Delhi on Friday launched the most advanced version of TomoTherapy Radixact X9– the smartest radiation therapy to treat the most complicated cancer tumours.

Tomotherapy comes as a boon for cancer treatment since it has a higher degree of precision, speed and accuracy.

Patients find it more comfortable to be treated under this technology owing to the rotational helical mechanism, also the set-up time is lesser as compared to other therapies.

“The launch of the most advanced version of the Tomotherapy technology is truly a remarkable development in the field of Radiation Oncology. This will be a revolutionary step in the treatment of cancer. With this system we can deliver both fractionated radiotherapy as well as SBRT and Radiosurgery,” said Suneeta Reddy, Managing Director, Apollo Hospitals Group.

“The new generation radiation machine and our highly experienced team enables us to move ahead towards precise and personalised care, therefore improving the quality of life of cancer patients and ensure better clinical outcomes,” Reddy added.

Tomotherapy is effective in treating cancer, irrespective of the stage, especially multiple metastasis. The best outcomes are for treatment of bilateral breast cancer, paediatric oncology and all other forms of cancer.

Cancer
Indraprastha Apollo Hospital in New Delhi on Friday launched the most advanced version of TomoTherapy Radixact X9– the smartest radiation therapy to treat the most complicated cancer tumours. Pixabay

“We are taking precision and excellence to the next level with the revolutionary Radixact-X9: Tomotherapy, system powered by state-of-the-art 3D CT imaging. It uses a linear accelerator to deliver high-dose radiation to the tumour with sub-millimetre precision,” said P ShivaKumar, Managing Director, Indraprastha Apollo Hospitals.

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“With the most recent introduction of Radixact X9, radiation oncology has reached a new horizon in the race of effective curative treatment for cancer. Large field size can be targeted at once. 1.35 cms of length can be targeted without repositioning the machine,” ShivaKumar added. (IANS)