Saturday August 24, 2019

Cannabis-Based Drug May Aid in Motor Neuron Disease

For the trial, the team included 60 adults (aged 18-80 years)

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Cannabis-based drug may help in motor neuron disease: Lancet. pixabay

A cannabis-based drug may help ease muscle movement for people suffering from motor neuron disease, the results of a clinical trial have shown.

The study, published in The Lancet Neurology journal, showed that chemical compounds — delta-9 tetrahydrocannabinol THC and cannabidiol (THC-CBD) — derived from the cannabis sativa plant given as an add-on treatment may help ease symptoms of spasticity (tight or stiff muscles).

Spasticity is a rapidly progressive, fatal neurodegenerative disorder affecting the nerve cells that control muscle movement. It is a major cause of disability and reduced quality of life in people with motor neuron disease.

Adults with motor neuron disease who took a combination of anti-spasticity drugs and cannabidiol experienced less spasticity and pain at six weeks follow-up compared with those given placebo.

“There is no cure for motor neuron disease so improved symptom control and quality of life are important for patients,” said lead researcher Nilo Riva from the San Raffaele Scientific Institute in Italy.

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In this July 12, 2018 file photo, a newly-transplanted cannabis cuttings grow in pots at a medical marijuana cultivation facility in Massachusetts. (VOA)

“Our trial showed a beneficial effect of THC-CBD spray in people on treatment-resistant spasticity and pain,” Riva added.

However, there is a need to confirm efficacy and safety of THC-CBD spray in larger, longer term phase 3 trials, Riva said.

For the trial, the team included 60 adults (aged 18-80 years).

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Spasticity and pain was significantly improved in the THC-CBD spray group compared with placebo.

Overall, THC-CBD spray was well tolerated and adverse events were mild to moderate, the researchers said. (IANS)

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Louisiana to Dispense Therapeutic Cannabis

Nine pharmacies are licensed to dispense medical marijuana across Louisiana and most are expected to open this week

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Alex Domino, right, the first ever person to legally receive medical marijuana in Louisiana, purchases his dose at Capitol Wellness Solutions, in Baton Rouge, Louisiana, Aug. 6, 2019. VOA

A Marine veteran struggling with PTSD and a woman fighting cancer became some of the first people to purchase medical marijuana in Louisiana on Tuesday, as the state became the first in the Deep South to dispense therapeutic cannabis, four years after state lawmakers agreed to give patients access to it.

Nine pharmacies are licensed to dispense medical marijuana across Louisiana and most are expected to open this week. Louisiana joins more than 30 other states that allow medical marijuana in some form. And though marijuana is banned at the federal level, a congressional amendment blocks the Justice Department from interfering with states’ medical marijuana programs.

A 41-year-old combat veteran from Belle Chasse, Louisiana, made his purchase at Capitol Wellness Solutions on Tuesday. He said he’d tried medical marijuana in California and it changed his life but he was happy to be able to purchase it in his home state.

“It has become a reality to my family this morning, waking up and knowing that I would be able to go home and for the first time in my long struggle, I’ll be able to do this legally in front of my family,” Gary Hess told reporters before making his purchase. “That’s incredible.”

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TJ Woodard, left, pharmacist in charge for Capitol Wellness Solutions, consults with Jeanette Anthony and her husband Albert Anthony, before he dispenses medical marijuana for Jeanette, a brain cancer patient, in Baton Rouge, Louisiana, Aug. 6, 2019. VOA

GB Sciences, one of two state-sanctioned growers, began shipping medical marijuana to Louisiana’s registered dispensaries Tuesday morning, after state regulators recently completed final tests and cleared it for release. Hundreds of patients in Louisiana have been awaiting the start of the program after years of work by lawmakers, who created the regulatory framework in 2015 for dispensing the cannabis. There also have been regulatory disputes and other hurdles.

State Sen. Fred Mills, a pharmacist in St. Martin Parish who sponsored the medical marijuana law, never thought it would take years for patients to gain access. He said he has repeatedly received “difficult calls” from people with cancer, seizures and other debilitating conditions and their family members asking when cannabis will reach pharmacy shelves.

“The toughest thing has been not being able to give people a definitive timeline that they could make plans for,” Mills said.

Randy Mire, owner of Capitol Wellness Solutions in Baton Rouge, saw three patients Tuesday and hosted a ribbon-cutting ceremony at his spa-like offices in the state’s capitol. He has hundreds more patients waiting. He said he specifically wanted to create a welcoming office space so patients could feel safe and that they were in a place where they wouldn’t be judged.

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For many of the patients, Tuesday was a big relief, he said.

“Maybe they’ve had to use medical marijuana not legally in the past and now they’re able to actually have a legal recommendation for this,” he said.

Only the Louisiana State University and Southern University agricultural centers are authorized to grow medicinal-grade pot.

Regulatory disagreements between GB Sciences, LSU’s grower, and state regulators in Louisiana’s agriculture department slowed getting the product to shelves, with medical marijuana advocates claiming the agency created unnecessary regulatory hurdles.

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A Marine veteran struggling with PTSD and a woman fighting cancer became some of the first people to purchase medical marijuana in Louisiana on Tuesday. Pixabay

Meanwhile, Southern broke ties with the first company it chose to grow marijuana, delaying its efforts. Southern’s new grower Ilera Holistic Healthcare planted its first crop two weeks ago and estimates its first product could be available by fall at the earliest.

Under the 2015 law and additional changes passed since then, Louisiana is allowing medical marijuana to treat a long list of diseases and disorders, such as cancer, seizure disorders, epilepsy, glaucoma, post-traumatic stress disorder and Parkinson’s disease.

Albert Anthony was at Capitol Wellness Solutions with his wife Jeanette, who suffers from a rare type of brain cancer. He said she hadn’t tried medical marijuana before but he had and hoped it would have some benefits for her such as increasing her appetite.

“That’s a great feeling, you know, that you can get a product that’s legal now and we’re just glad to see it come to pass,” he said.

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Doctors don’t issue a prescription but a “physician recommendation form,” a legal nuance aimed at keeping doctors from jeopardizing their medical licenses because federal law prohibits prescribing marijuana. Eighty-eight doctors around the state have been approved for the Louisiana permit required to offer medical-grade pot to patients.

Marijuana can be available in oils, pills, liquids, topical applications and an inhaler, such as that used by asthma patients — but not in a smokeable form.

GB Sciences’ first product will be liquid tinctures, in three different concentrations. John Davis, GB Sciences Louisiana president, said he expects to have dissolving strips taken by mouth available in a month, followed by topical creams.

Pharmacies set their own price for the products, and insurance won’t be covering the cost, so patients will have to pay out of pocket. Mire said the cost at his pharmacy will range from $99 to $200 per product. (VOA)