Sunday December 8, 2019

Cannabis-Based Drug May Aid in Motor Neuron Disease

For the trial, the team included 60 adults (aged 18-80 years)

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Cannabis-based drug may help in motor neuron disease: Lancet. pixabay

A cannabis-based drug may help ease muscle movement for people suffering from motor neuron disease, the results of a clinical trial have shown.

The study, published in The Lancet Neurology journal, showed that chemical compounds — delta-9 tetrahydrocannabinol THC and cannabidiol (THC-CBD) — derived from the cannabis sativa plant given as an add-on treatment may help ease symptoms of spasticity (tight or stiff muscles).

Spasticity is a rapidly progressive, fatal neurodegenerative disorder affecting the nerve cells that control muscle movement. It is a major cause of disability and reduced quality of life in people with motor neuron disease.

Adults with motor neuron disease who took a combination of anti-spasticity drugs and cannabidiol experienced less spasticity and pain at six weeks follow-up compared with those given placebo.

“There is no cure for motor neuron disease so improved symptom control and quality of life are important for patients,” said lead researcher Nilo Riva from the San Raffaele Scientific Institute in Italy.

Marijuana, Canada
In this July 12, 2018 file photo, a newly-transplanted cannabis cuttings grow in pots at a medical marijuana cultivation facility in Massachusetts. (VOA)

“Our trial showed a beneficial effect of THC-CBD spray in people on treatment-resistant spasticity and pain,” Riva added.

However, there is a need to confirm efficacy and safety of THC-CBD spray in larger, longer term phase 3 trials, Riva said.

For the trial, the team included 60 adults (aged 18-80 years).

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Spasticity and pain was significantly improved in the THC-CBD spray group compared with placebo.

Overall, THC-CBD spray was well tolerated and adverse events were mild to moderate, the researchers said. (IANS)

Next Story

Regular Cannabis Smokers Face Increased Risk of Testicular Cancer

Every year, around 2,400 UK men, half under the age of 35, get testicular cancer diagnosis

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Cancer
Cancer Ribbon. Pixabay

Men increase the risk of developing testicular cancer by 36 per cent by regularly smoking cannabis, a media report said quoting a US study.

US experts have listed their findings in the monthly journal of the American Medical Association, saying, “Regular marijuana use was associated with development of testicular germ cell tumours. Sustained marijuana use may increase the risk for testicular cancer.”

DOJ, Marijuana, Growers
Marijuana grows at an indoor cannabis farm in Gardena, California, Aug. 15, 201. VOA

According to the Daily Mail Online, the researchers found that long-term cannabis users were 36 per cent more likely to develop testicular cancer than others who did not use the drug.

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Those in favour of legalisation of “recreational” use of cannabis sometimes suggest that the drug’s compounds can fight cancer.

Every year, around 2,400 UK men, half under the age of 35, get testicular cancer diagnosis. (IANS)