Tuesday November 12, 2019

Cheap anti-inflammatory Drug for Common Cold can Stop Spread of Cancer, say Japanese Researchers

The study conducted using animal model showed that injecting flufenamic acid a much cheaper cold drug into cancerous bladder cells can suppress the cells

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Representational image. Pixabay

Tokyo, October 18, 2016: A non-steroid, anti-inflammatory drug used for treating common cold has the potential to suppress the spread of bladder cancers as well as reduce their resistance to anti-cancer drugs in mice, Japanese researchers have found.

Bladder cancer — the seventh most common cancer in males worldwide — can be grouped into two types: non-muscle-invasive cancer, which has a five-year survival rate of 90 percent, and muscle-invasive cancer, which have poor prognoses.

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The latter are normally treated with such anti-cancer drugs as cisplatin, but tend to become chemo-resistant and, thus, spread to organs such as the lungs and liver, as well as bone, the study said.

The study conducted using animal model showed that injecting flufenamic acid — a much cheaper cold drug — into cancerous bladder cells can suppress the cells’ invasive activities and restore the effectiveness of anti-cancer drugs.

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“The study could pave the way for medical institutions to use flufenamic acid which has unexpectedly been proven to be effective at fighting cancers,” said Shinya Tanaka from Hokkaido University in Japan.

In the study, using rats the team created a xenograft bladder cancer model and discovered a three to 25-fold increase of the metabolic enzyme aldo-keto reductase 1C1 (AKR1C1).

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It was also identified for the first time that AKR1C1 enhances tumour-promoting activities and proved the enzyme blocks the effectiveness of cisplatin and other anti-cancer drugs, which can be inhibited by flufenamic acid, the researchers concluded in the paper published in the journal Scientific Reports. (IANS)

  • Ruchika Kumari

    Japanese Researchers have done good job. A proper campaign is much needed so more and more people come to know about this research.

  • Antara

    Hope it really works!

Next Story

Quitting Smoking Reduces Risk of Bladder Cancer in Women: Study

Our study emphasizes the importance of primary prevention (by not beginning to smoke) and secondary prevention (through smoking cessation) in the prevention of bladder cancer among postmenopausal women

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Representational Image. Woman smoking. Image source: www.dailyjoint.com

Quitting smoking can reduce the risk of bladder cancer in older women, says a study, adding that the most significant reduction in risk occurred in the first 10 years after quitting.

The researchers used various statistical models to analyse the association between the years since quitting smoking and the risk of bladder cancer.

For the study, the researchers included data from 143,279 women, all of whom had supplied information on whether they had ever smoked cigarettes, how much they had smoked and whether they were current smokers.

The study found that 52.7 per cent of the women were categorised as “never smokers,” 40.2 per cent as former smokers, and 7.1 per cent as current smokers.

marijuana, cancer
Quitting smoking cuts bladder cancer risk in women. Pixabay

“Although bladder cancer is a fairly rare cancer type, representing an estimated 4.6 per cent of new cancer cases in 2019, it is the most common malignancy of the urinary system, with high recurrence rate and significant mortality,” said Yueyao Li, Ph.D candidate from the School of Public Health, Indiana University in Bloomington, US.

“Smoking is a well-established risk factor for bladder cancer, but findings on the relationship between duration of smoking cessation and the reduction in bladder cancer risk are inconsistent,” Li added.

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Published in the journal Cancer Prevention Research, the study found that the steepest reduction in risk occurred in the first 10 years after quitting smoking, with a 25 per cent drop. The risk continued to decrease after 10 years of quitting.

“Our study emphasizes the importance of primary prevention (by not beginning to smoke) and secondary prevention (through smoking cessation) in the prevention of bladder cancer among postmenopausal women,” said Li. (IANS)