Monday February 24, 2020

Chinese Scientists Develop Combined Tumor-Killing Therapy

The Chinese Academy of Sciences and Fudan University developed a common immune checkpoint inhibitor in a nanoparticle formulation

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Chinese, Scientists, Tumor
The study published on Friday in the journal Science Immunology described the new cancer immunotherapy that can prevent the immune system from becoming tolerant of tumors. Pixabay

Chinese scientists developed a combined tumor-killing therapy that can be activated specifically at tumor sites in mouse models of cancer, which is more effective than previous similar therapies.

The study published on Friday in the journal Science Immunology described the new cancer immunotherapy that can prevent the immune system from becoming tolerant of tumors, which occurs in 30 per cent of all cancer patients, the Xinhua news agency reported.

A team led by Wang Dangge from Shanghai Institute of Materia Medica under the Chinese Academy of Sciences and Fudan University developed a common immune checkpoint inhibitor in a nanoparticle formulation, which is highly tumor-specific.

The checkpoint inhibitor is a kind of increasingly popular anti-tumor drug. It can block proteins that keep immune T cells from killing cancer. But the checkpoint inhibitor used to target those immune system-suppressing proteins like PD-1 and PD-L1 often fails to reach deep-seated or metastatic tumors.

Chinese, Scientists, Tumor
Chinese scientists developed a combined tumor-killing therapy that can be activated specifically at tumor sites in mouse models of cancer, Pixabay

Wang’s team combined the nanoparticles carrying PD-L1-targeting antibodies with a light-activated molecule. The molecule called photosensitiser can produce tumor-killing reactive oxygen species after encountering a protein abundant in tumors, according to the study.

In mouse models, a local near-infrared radiation that activated the photosensitiser, along with the administration of antibodies-carrying nanoparticles, promoted the infiltration of cancer cell-killing T cells into the tumor site and made the tumors more sensitive to the checkpoint blockade.

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This combination also helped the nanoparticles effectively suppress tumor growth and metastasis to the lung and lymph nodes, resulting in approximately 80 per cent mouse survival over 70 days, compared to complete mouse death in 45 days in the group treated with only PD-L1 antibodies, according to the study. (IANS)

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Jupiter not as Dry as it was Predicted to be: NASA Scientists

Jupiter not as dry as earlier thought, reveals new NASA probe

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Jupiter
Jupiter may not be as dry as earlier shown by a NASA probe, according to the first science. (Representational Image). Pixabay

The largest planet in our solar system may not be as dry as earlier shown by a NASA probe, according to the first science results revealed by the US space agency’s Juno mission on the amount of water in Jupiter’s atmosphere.

At the equator, water makes up about 0.25 per cent of the molecules in Jupiter’s atmosphere — almost three times that of the Sun, said the study published in the journal Nature Astronomy.

These are also the first findings on the gas giant’s abundance of water since NASA’s 1995 Galileo mission suggested Jupiter might be extremely dry compared to the Sun. The comparison is based not on liquid water but on the presence of its components, oxygen and hydrogen, present in the Sun.

“We found the water in the equator to be greater than what the Galileo probe measured,” said Cheng Li, a Juno scientist at the University of California, Berkeley. “Because the equatorial region is very unique at Jupiter, we need to compare these results with how much water is in other regions,” Li said.

An accurate estimate of the total amount of water in Jupiter’s atmosphere has been on the wish lists of planetary scientists for decades. The figure in the gas giant represents a critical missing piece to the puzzle of our solar system’s formation.

Jupiter
These are also the first findings on the gas giant’s abundance of water since NASA’s 1995 Galileo mission suggested Jupiter might be extremely dry compared to the Sun. (Representational Image). Pixabay

Jupiter was likely the first planet to form, and it contains most of the gas and dust that was not incorporated into the Sun.

Water abundance also has important implications for the gas giant’s meteorology (how wind currents flow on Jupiter) and internal structure. While lightning — a phenomenon typically fuelled by moisture — detected on Jupiter by Voyager and other spacecraft implied the presence of water, an accurate estimate of the amount of water deep within Jupiter’s atmosphere remained elusive.

Before the Galileo probe stopped transmitting 57 minutes into its Jovian descent in December 1995, it radioed out spectrometer measurements of the amount of water in the gas giant’s atmosphere down to a depth of about 120 kilometres. The scientists working on the data were dismayed to find ten times less water than expected.

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A rotating, solar-powered spacecraft Juno was launched in 2011. Because of the Galileo probe experience, the mission seeks to obtain water abundance readings across large regions of the immense planet.

The Juno science team used data collected during Juno’s first eight science flybys of Jupiter to generate the findings. (IANS)