Drug-Free Compound can Ease Arthritis Pain

It has been found that rose-hip has the power to reduce the agony of osteoarthritis sufferers

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Drug-Free Compound can Ease Arthritis Pain
Drug-Free Compound can Ease Arthritis Pain. Pixabay

People suffering from arthritis can reduce pain by 90 percent with a drug-free compound derived from rose-hip, the fruit of the rose plant, new research indicates.

It has been found that rose-hip has the power to reduce the agony of osteoarthritis sufferers.

Human trials suggest a compound called GOPO, found in the rosa canina species of rose-hip, could provide a breakthrough for six million people whose lives are blighted by joint pain.

Rose hip
Rose hip. Pixabay

Danish researchers found the specially cultivated compound reduced nagging joint pain in the hands of nine out of 10 of the trial participants when it was taken in supplement form, reports femalefirst.co.uk.

Debilitating stiffness in finger and thumb joints can make tasks like opening jars, holding cutlery and tying shoelaces nearly impossible.

Also Read: How Chikungunya Virus Causes Arthritis Pain Decoded

The results of investigations carried out at Frederiksberg University in Copenhagen and published in the Open Journal of Rheumatology and Autoimmune Disease, demonstrate that the extract could offer natural pain relief, showing that sufferers were a third less likely to use conventional painkillers after taking the supplement. (Bollywood Country)

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Here’s Everything You Need to Know About Arthritis and COVID-19

Arthritis and coronavirus: All you need to know

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COVID-19 arthritis
Older people are more prone to novel Covid-19, owing to their underlying health conditions which weaken their body immunity with age. Flickr

Older people are more prone to novel Covid-19, owing to their underlying health conditions which weaken their body immunity with age. Arthritis is one of the most common health problems that comes with age and though arthritis can be immune-related (Rheumatoid arthritis) or non-immune-related (osteoarthritis), patients should take utmost precautions to reduce the risk of infection during this pandemic.

Vipul Jain, Chief Executive Officer, Advancells answers important questions regarding healthcare management for arthritis patients in times of Covid-19.

Q. Is arthritis a major risk factor for Covid-19?

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Jain: When it comes to Covid-19, arthritis may not be on the frontline as cardiovascular risks or metabolic disorders in the category of underlying health conditions, but a higher percentage of the older patients who are more prone to coronavirus infection, are suffering from arthritis. Arthritis and immune dysfunction go a long way. Pain and inflammation in arthritis can trigger immune system to function in an autoimmune manner by harming one’s own body and conversely, the immune system can also trigger autoimmune disorders like rheumatoid arthritis. Thus severe arthritis can damage the body from within and pave an easier path of coronavirus to attack.

COVID-19 arthritis
When it comes to Covid-19, arthritis may not be on the frontline as cardiovascular risks or metabolic disorders in the category of underlying health conditions. Flickr

Q. Are patients with autoimmune or inflammatory arthritis more prone to the virus?

Jain: In general, people with inflammatory arthritis with severe conditions seem to have an increased risk of coronavirus infections due to higher levels of immune deregulation. Arthritis experts emphasize that one of the main concerns for people with autoimmune disease is due to the immunosuppressive drugs that they have been prescribed by their doctors. It is difficult for doctors to work around the effects of immunosuppressive drugs in case of treating coronavirus infections.

Q. How do immunosuppressive drugs risk Covid-19?

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Jain: Although it is not intrinsically known whether taking immunosuppressant drugs can further risk the infection of Covid-19, previous research suggests that some of the drugs used to treat autoimmune and inflammatory types of arthritis may contribute to higher risk or severity of viral infection. The concern with immune suppression in the body is that without a triggered immune system, the virus replication is more unchecked and could replicate more freely, causing more severe disease condition. Therefore, it is very important to let the doctor know regarding your medications one is already taking, if you find flu-like symptoms during this Covid-19 outbreak.

Also Read- Inflammatory Bowel Disease May Affect Women of Childbearing Age: Study

Q. Is there an alternative to NSAIDs for arthritis in times of Covid-19?

Jain: Immunosuppressive drugs like NSAIDs (Non-steroidal Anti-Inflammatory Drugs) can be continued for arthritis patients, after a thorough consultation with the doctor in case no symptoms of Covid-19 are suspected. Although, no direct confirmation has been reported against the use of NSAIDs for aged patients with arthritis in these times of coronavirus outbreak, but it is futile to take any risk regarding this without discussing with the appropriate medical personnel.

So, is there an alternative? Yes, the alternative is to go for immune-modulation instead of immune-suppression. And that is where stem cells come into the picture. Regenerative medicine treatment of arthritis can help one overcome the issue of immune-suppression and also support the body immune system to fight against viral infections. (IANS)

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Drugs That Treat Arthritis in Dogs Can Kill Cancer Cells: Study

Drug for arthritis in dogs can fight cancer in people

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Cancer Cells
Drugs for diabetes, inflammation, alcoholism and even for treating arthritis in dogs can also kill cancer cells. Pixabay

Drugs for diabetes, inflammation, alcoholism — and even for treating arthritis in dogs — can also kill cancer cells in the lab, according to a new health news and study.

The researchers systematically analysed thousands of already developed drug compounds and found nearly 50 that have previously unrecognised anti-cancer activity.

The findings, which also revealed novel drug mechanisms and targets, suggest a possible way to accelerate the development of new cancer drugs or repurpose existing drugs to treat cancer.

“We thought we’d be lucky if we found even a single compound with anti-cancer properties, but we were surprised to find so many,” said study researcher Todd Golub from Harvard University in the US.

Cancer Cells
Most of the non-oncology drugs that killed cancer cells in the study did so by interacting with a previously unrecognized molecular target. (Representational Image). Pixabay

The study, published in the journal Nature Cancer, yet to employ the Broad’s Drug Repurposing Hub, a collection that currently comprises more than 6,000 existing drugs and compounds that are either FDA-approved or have been proven safe in clinical trials (at the time of the study, the Hub contained 4,518 drugs).

Historically, scientists have stumbled upon new uses for a few existing medicines, such as the discovery of aspirin’s cardiovascular benefits.

“We created the repurposing hub to enable researchers to make these kinds of serendipitous discoveries in a more deliberate way,” said study first author Steven Corsello, from Dana-Farber Cancer Institute and founder of the Drug Repurposing Hub.

The researchers tested all the compounds in the Drug Repurposing Hub on 578 human cancer cell lines from the Broad’s Cancer Cell Line Encyclopedia (CCLE).

Using a molecular barcoding method known as PRISM, which was developed in the Golub lab, the researchers tagged each cell line with a DNA barcode, allowing them to pool several cell lines together in each dish and more quickly conduct a larger experiment.

The team then exposed each pool of barcoded cells to a single compound from the repurposing library, and measured the survival rate of the cancer cells.

They found nearly 50 non-cancer drugs — including those initially developed to lower cholesterol or reduce inflammation — that killed some cancer cells while leaving others alone.

Some of the compounds killed cancer cells in unexpected ways.

“Most existing cancer drugs work by blocking proteins, but we’re finding that compounds can act through other mechanisms,” said Corsello.

Cancer Cells
The researchers tested all the compounds in the Drug Repurposing Hub on 578 human cancer cells lines from the Broad’s Cancer Cell Line Encyclopedia. (Representational Image). Pixabay

Some of the four-dozen drugs researchers identified appear to act not by inhibiting a protein but by activating a protein or stabilising a protein-protein interaction.

For example, the team found that nearly a dozen non-oncology drugs killed cancer cells that express a protein called PDE3A by stabilising the interaction between PDE3A and another protein called SLFN12 — a previously unknown mechanism for some of these drugs.

These unexpected drug mechanisms were easier to find using the study’s cell-based approach, which measures cell survival, than through traditional non-cell-based high-throughput screening methods, Corsello said.

Also Read- Mothers Find Gaps in Accessibility of Breastfeeding Resources at Work: Research

Most of the non-oncology drugs that killed cancer cells in the study did so by interacting with a previously unrecognized molecular target.

For example, the anti-inflammatory drug tepoxalin, originally developed for use in people but approved for treating osteoarthritis in dogs, killed cancer cells by hitting an unknown target in cells that overexpress the protein MDR1, which commonly drives resistance to chemotherapy drugs. (IANS)

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Here are 5 Ways to Reduce Joint Pain in Winters

Ayurveda for joint pain in winters

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Joint Pain
A chronic osteoarthritis condition can cause stiffness, joint pain and loss of movement. Pixabay

Winter can be a difficult season for those battling joint pain.

A chronic osteoarthritis condition is caused when the cartilage in your joints wears down and the bones begin to rub and scrape against one another, causing stiffness, joint pain and loss of movement.

Here are some of the measures suggested by Dr. Partap Chauhan, Director, Jiva Ayurveda, which you can use to prevent joint pain from making your life difficult.

1. Daily joint rotations

Include daily joint rotations in your workout routine along with some low impact exercises like cycling and swimming. It will help you ease the joint pain and prevent worsening of the condition. Additionally, walking can also prove to be helpful, but make sure you don’t walk too fast and wear comfortable shoes that are relatively flat.

2. Practice Abhangya

It is a form of full body massage with medicinal oils. This therapy helps reduce vata and mobilises the toxins from tissues. To give yourself a proper massage, heat approximately one cup of organic sesame oil and apply on the entire body from scalp to toes. Massage using vigorous long strokes for at least 10 minutes each day. If you have rheumatoid arthritis, do not practice Abhyanga.

Olive oil joint pain
Consuming Olive oil, sesame oil or ghee can lubricate your joints and reduce joint pain. Pixabay

3. Include ghee in your diet

Arthritis is seen as a disease of excess vata, which reduces moisture throughout the body and causes loss of lubricity. Consumption of ghee (clarified butter), sesame oil or olive oil can help soothe inflammation, lubricate the joints, and banish arthritis stiffness.

4. Gentle yoga

Yoga provides a gentle form of exercise that helps maintain mobility of the joints. Practicing poses like Tadasana (Mountain pose), Virabhadrasana (Warrior pose) and Dandasana (Staff pose) can help reduce the pain in arthritis and increases the mobility.

Also Read- Go for these Skin Treatments in 2020

5. Proper diet

Maintaining a balanced diet is essential to managing joint pain. Consumption of grains like “raktashali” and “shasthika” lower the inflammation. Veggies and fruits like karela (Bitter Gourd), brinjal, neem and drumsticks are recommended along with berries and avocados.

Living with joint pain can be very difficult, especially if you’re getting on in age. While it’s possible to find short term relief by following the outlined tips, long term treatment of the condition will need professional intervention. (IANS)