Wednesday June 19, 2019

Drugs Taken To Neutralize Stomach Acids Can Lead To Kidney Diseases

According to the World Health Organisation, PPIs are essential medicines for many people, helping them to control symptoms that are often painful and disruptive to daily life. 

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Patients who took only PPIs reported a kidney-related adverse reaction at a frequency of 5.6 per cent against 0.7 per cent for patients who took only histamine-2 receptor antagonists. Pixabay

Intake of widely prescribed drugs to neutralise stomach acid by people with heartburn or stomach ulcers could be associated with increased risk of kidney disease, warns a study of over 40,000 patients.

The study, published in the Scientific Reports journal, showed patients who took proton pump inhibitors (PPIs) were more likely to experience kidney disease than those who took another type of drug used to dampen down acid production called H2 blockers.

The patients who took only PPIs were 28.4 times more likely to report chronic kidney disease, as well as acute kidney injury (4.2 times more likely), end-stage renal disease (35.5 times more likely) and unspecified kidney impairment (eight times more likely), said researchers including Ruben Abagyan, Professor from the University of California-San Diego.

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The study, published in the Scientific Reports journal, showed patients who took proton pump inhibitors (PPIs) were more likely to experience kidney disease than those who took another type of drug used to dampen down acid production called H2 blockers.
VOA

According to the World Health Organisation, PPIs are essential medicines for many people, helping them to control symptoms that are often painful and disruptive to daily life.

But Abagyan hopes this initial data will prompt healthcare providers to appropriately warn, educate and monitor patients who require PPIs, particularly if they are at an elevated risk for kidney disease and electrolyte abnormalities.

For the study, the team looked at a data of 43,000 patients who took PPIs and the control group, approximately 8,000 patients who took histamine-2 receptor blockers, such as Zantac or Pepcid, and no other medications.

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Patients who took only PPIs reported a kidney-related adverse reaction at a frequency of 5.6 per cent against 0.7 per cent for patients who took only histamine-2 receptor antagonists.

However, the researchers cautioned the study does not reveal absolute frequency of these kidney-related complaints for all people taking PPIs. A large, randomised, controlled clinical trial would be needed to show causality between PPI usage and absolute risk of kidney disease in humans. (IANS)

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Study Reveals, Stomach Issues A Result Of Psychosocial Deprivation At Early Ages

The study found that children with past caregiving disruptions showed higher levels of symptoms, including stomach aches, constipation, vomiting and nausea

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"Our study is among the first to link disruption of a child's gastrointestinal microbiome triggered by early-life adversity with brain activity in regions associated with emotional health," said Bridget Callaghan, postdoctoral candidate at the varsity.. Pixabay

If your child is suffering from trauma or extreme psychosocial deprivation, then s/he is at risk of developing stomach issues later which could affect the brain and behaviour, finds a new study.

The study found that children with past caregiving disruptions showed higher levels of symptoms, including stomach aches, constipation, vomiting and nausea.

In addition, they had distinctly different gut microbiomes from those raised with biological caregivers from birth, said the study published in the journal Development and Psychopathology.

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“It is too early to say anything conclusive, but our study indicates that adversity-associated changes in the gut microbiome are related to brain function, including differences in the regions of the brain associated with emotional processing,” said Tottenham. Pixabay

Children raised by parents had increased gut microbiome diversity, which is linked to the prefrontal cortex — a region of the brain known to help regulate emotions.

“One common reason children show up at doctors’ offices is intestinal complaints. Our findings indicate that gastrointestinal symptoms in young children could be a red flag to primary care physicians for future emotional health problems,” said Nim Tottenham, Professor Columbia University in the US.

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Children raised by parents had increased gut microbiome diversity, which is linked to the prefrontal cortex — a region of the brain known to help regulate emotions. Pixabay

“Our study is among the first to link disruption of a child’s gastrointestinal microbiome triggered by early-life adversity with brain activity in regions associated with emotional health,” said Bridget Callaghan, postdoctoral candidate at the varsity.

For the study, 115 children adopted from orphanages or foster care homes on or before approximately they were two years old and 229 children raised by a biological caregiver were analysed.

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“It is too early to say anything conclusive, but our study indicates that adversity-associated changes in the gut microbiome are related to brain function, including differences in the regions of the brain associated with emotional processing,” said Tottenham.

Although more research is needed, this study helps to fill in an important gap in the literature, the team noted. (IANS)