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The results, published online in the journal Nature Communications, indicate that these natural compounds may reduce depression by targeting newly discovered underlying mechanisms of the disease. Pixabay

Including grapes in your diet may have a positive impact on your mental health as researchers have found that certain grape-derived compounds might be developed as therapeutic agents for the treatment of depression.

“The discovery of these new, natural grape-derived polyphenol compounds targeting cellular and molecular pathways associated with inflammation may provide an effective way to treat a subset of people with depression and anxiety, a condition that affects so many people,” said lead researcher Giulio Maria Pasinetti, Professor at Icahn School of Medicine at Mount Sinai in New York.


Depression is associated with a multitude of pathological processes, including inflammation of the peripheral immune system, a set of biological structures and processes in the lymph nodes and other tissues that protect against disease and abnormalities involving synapses, the structures that permit neurons to pass an electrical or chemical signal to other neurons.

ALSO READ: Here is a List of Food to Counter Depression and Stress: Try them out!


Previous research has found that grape-derived polyphenols have some efficacy in modulating aspects of depression, yet the mechanisms of action had largely remained unknown until now. Pixabay

However, currently available antidepressants are largely restricted to targeting the systems that regulate serotonin, dopamine, and other related neurotransmitters, and these treatments do not specifically address inflammation and synaptic maladaptations that are now known to be associated with a major depressive disorder.

The new study found that a bioactive dietary polyphenol preparation from grape was effective in promoting resilience against stress-induced depression in mice.

ALSO READ: 5 Things You Can do to Treat Your Depression Instantly

Specifically, the researchers found that two grape-derived compounds dihydrocaffeic acid (DHCA) and malvidin-3′-O-glucoside (Mal-gluc) can promote resilience in mouse models of depression by modulating inflammation and synaptic plasticity, respectively.

“Our research shows that combination treatment with the two compounds can promote resilience against stress-mediated depression-like phenotypes by modulating systemic inflammatory responses and brain synaptic plasticity in a mouse model of depression,” said Jun Wang, Associate Professor at Icahn School of Medicine at Mount Sinai. (IANS)


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Photo by GOI.

New Education Policy 2020

On the first day of the two-day meeting of BJP and Rashtriya Swayamsevak Sangh (RSS) leaders on Tuesday, discussions were held on important issues related to education and the National Education Policy-2020.

Apart from senior RSS leader Suresh Soni, representatives of various organisations associated with the Sangh Parivar -- working in the field of education -- were present in the meeting in New Delhi.

According to sources, Union Education Minister Dharmendra Pradhan, who attended the meeting on behalf of the government, shared information related to the National Education Policy-2020 and the government's policy on important issues related to the education sector. Pradhan also shared details of the efforts being made by the government in the field of education.

Discussions were also held regarding the impact of the situation arising out of Corona and how much it has affected the education sector.

In the meeting, the RSS leaders asked several questions and provided suggestions to the Union Minister regarding the education policy of the government.

According to the sources, RSS wants the policy to be implemented expeditiously. All aspects related to the policy were discussed in Tuesday's meeting.

On the second and the last day of the meeting on Wednesday, special issues related to education will be discussed in which representatives of various organisations of the Sangh, Union Ministers and several BJP leaders will be take part.

Meanwhile, in order to convey its point of view to the government on various issues, the Sangh keeps on calling such coordination meetings related to specific issues, in which RSS representatives -- working in that particular area -- provide feedback to the government. (IANS/JB)

Keywords: BJP, RSS, New Education Policy, Education, India


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