Washington: Even a placebo with no medical value can ease pain in research participants, finds a study.
“We’re still learning a lot about the critical ingredients of placebo effects. What we think now is that they require both belief in the power of the treatment and experiences that are consistent with those beliefs,” said senior author Scott Schafer from the University of Colorado Boulder.
The brain plays a key role in subjects for whom the placebo gel worked, and that more research is warranted.
“Those experiences make the brain learn to respond to the treatment as a real event. After the learning has occurred, your brain can still respond to the placebo even if you no longer believe in it,” Schafer pointed out in The Journal of Pain.
For the study, the team applied a ceramic heating element to research subjects’ forearms.
The team then applied what the subject thought was an analgesic gel on the affected skin that turned down the temperature.
In fact, the treatment was vaseline with blue food colouring in an official looking pharmaceutical container.
“They believed the treatment was effective in relieving pain,” Schafer explained.
“After this process, they had acquired the placebo effect. We tested them with and without the treatment on medium intensity. They reported less pain with the placebo,” Schafer said.
The findings may open doors to new ways to treat drug addiction or aid in pain management for children or adults who have undergone surgery and are taking strong and potentially addictive painkillers.
“We know placebos induce the release of pain-relieving substances in the brain, but we don’t yet know whether this expectation-independent placebo effect is using the same or different systems,” Schafer concluded.
Air pollution is a major concern nowadays and has major effects on one’s health
There are many toxic air pollutants in our environment which can cause severe health hazards
Health-related problems like asthma, headaches, nausea, etc. can be caused as an effect of air pollution
Air Pollution and their dreadful consequences are not some newly found phenomena of the new-found world. There have been instances of hazardous effects even in the past. The three major historic documentation, dating back to the middle of the 20th century, happened at Meuse Valley in Belgium, Donora in Pennsylvania, and London. The most gruesome of the three is the well-known London mishap that claimed over 4000 lives during the episode, due to temperature inversion and associated elevated levels of Air Pollution, and over 8000 lives in the subsequent period.
Mankind is in a fast-paced race, always in the process of trying to outwit each other. The numerous developments born out of this race have brought along with them dreadful health consequences. Air Pollution is one such inadvertent yet a disregardful act by humans. The pollution does not begin only when you step out of your homes but is present within your safety havens itself.
According to the World Health Organization report in 2014, 92% of the world population was living in places where the air quality guidelines levels were not met. Outdoor Air Pollution was cited to be the cause of 3.7 million premature deaths in both cities and rural areas. Around 80% of those deaths were due to heart diseases and stroke, and the rest were due to respiratory illnesses and cancers due to exposure to fine particulate matter.
Air pollutants categories:
Air pollutants are categorized into two groups based on their impact, Criteria pollutants and Toxic air pollutants. Criteria pollutants include particulate matter (PM), ozone (O3), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and lead (Pb). (defined by the United States Environmental Protection Agency in the Clean Air Act). These pollutants are present everywhere and cause health issues when present at significant ambient levels. In general, the criteria pollutants are regarded as the cause of most respiratory and cardiac issues.
Toxic air pollutants are also known as “hazardous air pollutants,” are substances that cause cancer or lead to other potential non-cancerous effects on the reproductive and neurological systems and have disastrous consequences in the development process. It is also assumed that there is no threshold level of exposure required to cause cancer. Meaning any amount of exposure to these toxic pollutants can lead to cancer.
At risk Populations:
In any geography, the already ailing and sick (pre-existing medical condition) population is more at risk for suffering from the ill effects of air pollution. Apart from this category, young children are the next at risk.
The reason for children being affected more is that they have higher breathing rates than adults. Therefore, they unknowingly inhale a lot more pollutants than an average adult. The potential for exposure is also increased with increased amount of time spent outdoors. The developing lungs of the young people have a limited metabolic capacity to placate toxicity.
Air Pollution Respiratory Diseases:
The small particulate matter of the criteria pollutants has the capacity to reach the lowest portion of the lungs, where the gaseous exchange occurs. The larger particles get trapped in the nose and the medium- sized ones settle in the tracheobronchial region.
The effects of the settlement of these particles are upper and lower respiratory symptoms, asthma attacks, loss of quality living days, and restricted activities. Chronic exposure to particulate matter has also been associated with the development of chronic bronchitis- inflammation of the lining of the bronchial tubes. This condition presents as a cough with mucus.
It is a commonly known fact and an “ought to be stressed upon” fact that chronic exposure to polluted air can also lead to the cancer of the lungs.
Ozone, an oxidant gas that is poorly water-soluble, travels throughout the respiratory tract due to its nature of solubility. It reacts with the molecules on the surface of the lung and leads to pulmonary oedema, inflammation, and the destruction of epithelial cells that line the respiratory tract. Children who stay outdoors in high Ozone areas develop asthma. Some of the disastrous effects are permanent in nature.
Some more Criteria air pollutants:
When Carbon monoxide reacts with blood haemoglobin, it reduces the oxygen-carrying capacity of blood and hence can cause damage to the nervous system. It causes a headache, fatigue, dizziness, coma, respiratory failure, and eventually death.
Nitrogen dioxide is mostly an indoor air pollutant released due to the increasing use of gas stoves. Exposure to high levels of nitrogen dioxide can lead to respiratory distress with symptoms such as cough, shortness of breath, and tightness in the chest.
Air Pollution Cardiovascular Effects:
The above-mentioned actions of air pollutants in the respiratory tract can also affect the cardiovascular system. The inflammation in the breathing tract induces transient hypercoagulability (abnormal blood clotting), the progression of atherosclerosis, and propensity to plaque rupture, especially in people with coronary atheroma. Long-term exposure to Air Pollution can also speed up the atherogenesis process, heart rate invariability, and arrhythmia (irregular heartbeat). Some recent studies have also found a significant relationship between heart attack (Myocardial infarction) and exposure to polluted air.
Air Pollution in Reproductive and Child Health:
Long-term exposure to the air pollutants poses risks even to an unborn child. It causes Intrauterine growth restriction -low birth weight at term, intrauterine growth retardation, smaller fetus for gestational age etc.
Indoor Air Pollution :
Some of the major causes of indoor air pollution are indoor smoking and burning of fuels for cooking purposes, especially in the second and third world countries. The people in these countries cook and heat their homes with biomass fuels and coal. Thus the main noxious gas released is sulfur dioxide, that causes respiratory issues and eye irritation
Quality of life:
Man is not just affected physically but his mental peace takes a toll too when the feelings of insecurity and the perception of having to live in a hazardous environment take over. Severe annoyance, sleep disturbances, reduced the ability to concentrate, communicate or perform normal daily tasks also accompany the psychological stress issues.
Some of the issues are too massive to be controlled at an individual level but a resolution to change can, of course, make a significant impact. Individually we are just one drop of water but together we can make a big ocean.
Simple steps involve following the government regulations in your state regarding the upkeep of your vehicles, carpooling, avoiding the burning of coal, adequate ventilation of your homes to dilute the effect of indoor air pollutants among others.