Friday July 20, 2018

Exercise may mitigate side-effects of Hormone-therapy Drugs that significantly reduce risk of Breast Cancer

AIs treatment can be a double-edged sword because they often lead to bone loss or severe joint pain, especially if the survivors are obese or overweight

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FILE - A biotechnician demonstrates the loading of a genome sequencing machine at the J. Craig Venter Institute in Rockville, Maryland. Relative to their ability to pay, cancer patients in China and India face much higher prices than wealthier U.S. patients. VOA
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New York, Jan 19, 2017: A combination of weight training and 150 minutes of moderate aerobic activity — such as brisk walking or jogging — every week may help mitigate the side-effects of hormone-therapy drugs that significantly reduce the risk of breast cancer recurrence in post-menopausal survivors, shows a recent study.

Because most breast cancers are hormone receptor-positive — that is, they use estrogen or progesterone to grow and spread — survivors often rely on hormone therapy, such as Aromatase Inhibitors (AIs), to keep the disease from returning.

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However, this AIs treatment can be a double-edged sword because they often lead to bone loss or severe joint pain, especially if the survivors are obese or overweight.

“These changes put women at risk for frailty fractures and osteoporosis, not to mention further risk for comorbid chronic disease and cancer reoccurrence,” said Gwendolyn Thomas, assistant professor at Syracuse University in New York, US.

Hence, nearly 40 per cent of survivors stop taking AIs long before their customary five-year treatment period expires and increase the chances of their breast cancer re-occurring, Gwendolyn said.

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Interventions that address obesity in women taking AIs can help them continue this necessary treatment, the researchers continued.

For the study, participants did two sessions of weight training and 150 minutes of moderate aerobic activity, such as brisk walking or jogging, every week for a year.

“We noticed a drop in per cent body fat and body mass index, as well as a significant increase in their lean body mass. These changes have clinical benefits, but also suggest that exercise should be prescribed in conjunction with AIs, as part of a regular treatment regimen,” Thomas said.

The study was published in the Obesity Journal. (IANS)

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Eating Dinner Early May Lower Risk of Breast, Prostate Cancer

The research suggests that long-term late night snacking may have the similar effect to night-shift work and circadian disruption

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The researchers found that cancer patients were more likely to have dinner late at night. Pixabay

Having your last meal before 9 pm or at least two hours before going to bed could lower the risk of breast and prostate cancer, suggests a new study.

Compared to those who have supper after 10 pm or those who go to bed right after meal, people who take their evening meal before 9 pm or wait at least two hours before going to sleep have approximately 20 per cent lower risk of those types of cancers, the findings showed.

“Our study concludes that adherence to diurnal eating patterns is associated with a lower risk of cancer,” said lead author Manolis Kogevinas from the Barcelona Institute for Global Health (ISGlobal) in Spain.

“The findings highlight the importance of assessing circadian rhythms in studies on diet and cancer,” Kogevinas added.

For the study, published in International Journal of Cancer, the team analysed data from 621 cases of prostate cancer and 1,205 cases of breast cancer, as well as 872 male and 1,321 female controls.

Having your last meal before 9 pm or at least two hours before going to bed could lower the risk of breast and prostate cancer
Having your last meal before 9 pm or at least two hours before going to bed could lower the risk of breast and prostate cancer. Pixabay

The participants, were interviewed about their meal timing, sleep habits and chronotype — an individual attribute correlating with preference for morning or evening activity.

The participants also completed a questionnaire on their eating habits and adherence to cancer prevention recommendations.

The researchers found that cancer patients were more likely to have dinner late at night.

Also Read: Meditation Improves Mood, Sleep in Teenagers with Cancer

Breast and prostate cancers are also among those most strongly associated with night-shift work, circadian disruption and alteration of biological rhythms.

The research suggests that long-term late night snacking may have the similar effect to night-shift work and circadian disruption.

“If the findings are confirmed, they will have implications for cancer prevention recommendations, which currently do not take meal timing into account,” Kogevinas noted. (IANS)