Wednesday November 20, 2019

Exercise may mitigate side-effects of Hormone-therapy Drugs that significantly reduce risk of Breast Cancer

AIs treatment can be a double-edged sword because they often lead to bone loss or severe joint pain, especially if the survivors are obese or overweight

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FILE - A biotechnician demonstrates the loading of a genome sequencing machine at the J. Craig Venter Institute in Rockville, Maryland. Relative to their ability to pay, cancer patients in China and India face much higher prices than wealthier U.S. patients. VOA

New York, Jan 19, 2017: A combination of weight training and 150 minutes of moderate aerobic activity — such as brisk walking or jogging — every week may help mitigate the side-effects of hormone-therapy drugs that significantly reduce the risk of breast cancer recurrence in post-menopausal survivors, shows a recent study.

Because most breast cancers are hormone receptor-positive — that is, they use estrogen or progesterone to grow and spread — survivors often rely on hormone therapy, such as Aromatase Inhibitors (AIs), to keep the disease from returning.

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However, this AIs treatment can be a double-edged sword because they often lead to bone loss or severe joint pain, especially if the survivors are obese or overweight.

“These changes put women at risk for frailty fractures and osteoporosis, not to mention further risk for comorbid chronic disease and cancer reoccurrence,” said Gwendolyn Thomas, assistant professor at Syracuse University in New York, US.

Hence, nearly 40 per cent of survivors stop taking AIs long before their customary five-year treatment period expires and increase the chances of their breast cancer re-occurring, Gwendolyn said.

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Interventions that address obesity in women taking AIs can help them continue this necessary treatment, the researchers continued.

For the study, participants did two sessions of weight training and 150 minutes of moderate aerobic activity, such as brisk walking or jogging, every week for a year.

“We noticed a drop in per cent body fat and body mass index, as well as a significant increase in their lean body mass. These changes have clinical benefits, but also suggest that exercise should be prescribed in conjunction with AIs, as part of a regular treatment regimen,” Thomas said.

The study was published in the Obesity Journal. (IANS)

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A Molecule in Immune System Can Target and Kill Cancer Cells: Study

Crucially, there is a need to induce the immune system to ensure long-term protection against the recurrence of cancer

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Immune
Current approaches to achieve this involve killing Cancer cells by using chemotherapeutics and other agents which could be harmful and have uncertain outcomes other than Immune Bacteria. Pixabay

Researchers have found a naturally occurring molecule and a component of the Immune system that could successfully target and kill Cancer cells, according to a study.

The study, published in British Journal of Cancer, discovered that beta-galactoside-binding protein, a naturally occurring molecule produced by immune cells can non-specifically target cancer cells, make them undergo cell death and through a stress response pathway make the cancer cells visible to the immune system to prompt an anti-cancer immune response that would secure protection against recurrences.

“By contrast, the anti-tumour property of the molecule is selective and not harmful to normal cells. It is effective against the most aggressive colorectal cancer cells and a wide range of other cancer cells equally unresponsive to current therapies,” said study lead author Professor Livio Mallucci from King’s College London.

“This research presents experimental evidence for a strategy where the targeting of cancer cells and the stimulation of immunity combine to prompt immediate and long-term responses against aggressive cancer,” he said.

According to the researchers, major developments in anti-cancer therapies have taken place over the last decade, but as only a subset of patients respond to treatments, there is a need for further development.

Crucially, there is a need to induce the immune system to ensure long-term protection against the recurrence of cancer.

Immune
Researchers have found a naturally occurring molecule and a component of the Immune system that could successfully target and kill Cancer cells, according to a study. Pixabay

Current approaches to achieve this involve killing cells by using chemotherapeutics and other agents which could be harmful and have uncertain outcomes, the study said.

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“Translation of the molecule to the clinic could open a new therapeutic opportunity which safely combines direct killing of cancer cells and the stimulation of the immune system against recurrences, a significant step forward in the management of cancer,” he added. (IANS)