Tuesday June 25, 2019
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First Successful Case Of Womb Transplant in Brazil

In the Brazilian case, the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Küster-Hauser syndrome. The donor was 45 and died of a stroke.

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Womb Transplant
Medical team hold the first baby born via uterus transplant from a deceased donor at the hospital in Sao Paulo, Brazil. VOA

A woman in Brazil who received a womb transplanted from a deceased donor has given birth to a baby girl in the first successful case of its kind, doctors reported.

The case, published in The Lancet medical journal, involved connecting veins from the donor uterus with the recipient’s veins, as well as linking arteries, ligaments and vaginal canals.

It comes after 10 previously known cases of uterus transplants from deceased donors – in the United States, the Czech Republic and Turkey – failed to produce a live birth.

The girl born in the Brazilian case was delivered via caesarean section at 35 weeks and three days, and weighed 2,550 grams (nearly 6 lbs), the case study said.

Dani Ejzenberg, a doctor at Brazil’s Sao Paulo University hospital who led the research, said the transplant – carried out in September 2016 when the recipient was 32 – shows the technique is feasible and could offer women with uterine infertility access to a larger pool of potential donors.

Womb
. The woman’s previously fertilized and frozen eggs were implanted after seven months and 10 days later she was confirmed pregnant.. Pixabay

The current norm for receiving a womb transplant is that the organ would come from a live family member willing to donate it.

“The numbers of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population,” Ejzenberg said in a statement about the results.

She added, however, that the outcomes and effects of womb donations from live and deceased donors have yet to be compared, and said the technique could still be refined and optimised.

The first baby born after a live donor womb transplant was in Sweden in 2013. Scientists have so far reported a total of 39 procedures of this kind, resulting in 11 live births.

Experts estimate that infertility affects around 10 to 15 percent of couples of reproductive age worldwide. Of this group, around one in 500 women have uterine problems.

Before uterus transplants became possible, the only options to have a child were adoption or surrogacy.

Infants, baby, WOmb
The case, published in The Lancet medical journal, involved connecting veins from the donor uterus with the recipient’s veins. Pixabay

In the Brazilian case, the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Küster-Hauser syndrome. The donor was 45 and died of a stroke.

Also Read: Pregnancy is Possible For Survivors of Breast Cancer

Five months after the transplant, Ejzenberg’s team wrote, the uterus showed no signs of rejection, ultrasound scans were normal, and the recipient was having regular menstruation. The woman’s previously fertilized and frozen eggs were implanted after seven months and 10 days later she was confirmed pregnant.

At seven months and 20 days – when the case study report was submitted to The Lancet – the baby girl was continuing to breastfeed and weighed 7.2 kg (16 lb). (VOA)

Next Story

Baby Gene Experiment Foolish and Dangerous: Experts

Professor He Jiankui shocked the world when he genetically altered the twins

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Baby, Gene, Experiment, Foolish
Professor He Jiankui shocked the world when he genetically altered the twins to try to give them protection against HIV. Pixabay

The first people to be gene-edited — a pair of baby twin girls — may have been mutated in a way that shortens life expectancy, research suggests.

Professor He Jiankui shocked the world when he genetically altered the twins to try to give them protection against HIV, the BBC reported.

However, now a study in Nature Medicine shows people who naturally have the mutation — he was trying to recreate — were significantly more likely to die young.

Experts said Prof He’s actions were “very dangerous” and “foolish”.

Baby, Gene, Experiment, Foolish
The first people to be gene-edited a pair of baby twin girls may have been mutated in a way that shortens life expectancy.Pixabay

Prof He was targeting a gene called CCR5. It is a set of genetic instructions that are important for how the immune system functions. They are also the doorway that human immunodeficiency virus (HIV) walks through to infect cells.

Mutations to CCR5 essentially lock the door and give people resistance to HIV. So, Prof He made embryos in an IVF clinic and then used gene-editing technologies on the twins to alter the CCR5 gene.

Resulting in girls — named Lulu and Nana — who were born last year.

The problem is CCR5 has a bigger role in the body than just making people vulnerable to HIV. It is active in the brain and in fighting off other infections, particularly flu.

Also Read- Federal Judge to Hear Bid to Block New Indiana Abortion Procedure Ban

The study, at the University of California, Berkeley, looked at nearly 410,000 people in the UK, among them those who had only the mutated version of CCR5 were 20 per cent more likely to die before they turned 78. (IANS)