Saturday, December 5, 2020
Home Life Style Health & Fitness Genetic differences lead to failure of anti-HIV drug

Genetic differences lead to failure of anti-HIV drug

Washington, Genetic variations and not complying with treatment regimens may account for some failures of an anti-HIV drug to treat and prevent the infection.

335238FA-F319-41E1-A55AB94B28EB1600The drug Tenofovir, marketed as Viread, is processed differently according to cell locations, the study said.

This is to see if the drug is eventually marketed as a topical gel, it can work differently depending on whether it is applied to the vagina or the rectum.

“Our results suggest that in future, before prescribing tenofovir to a patient, a doctor could order genetic testing and know in advance if it works, and prescribe a different drug if it won’t,” said Namandje Bumpus, associate professor of medicine at the Johns Hopkins University School of Medicine.

In the study described in the journal EBio-Medicine, the team focused on a search for the human enzymes that convert tenofovir from its original form to an activated one that combats HIV.

The team “knocked out” genes for phosphate-adding enzymes one by one, then exposed the tissues’ cells to tenofovir.

They found that the enzyme called pyruvate kinase was different from that which performed the second activation step in the colorectal tissues.

The team sequenced the genes of 142 women who had participated in a clinical trial of tenofovir to look for genetic variations that might have affected the function of the enzyme.

They found 71 such variants, several of which a computer model predicted would make the enzyme ineffective.

Altogether, eight percent of the women had genetic variants that were likely to make them unable to convert tenofovir to its activated form.

“Tenofovir has been shown in trials to be very effective, so when it does not work, researchers and clinicians tend to assume the individual just was not taking the drug as directed,” Bumpus said.

(IANS)

STAY CONNECTED

19,120FansLike
362FollowersFollow
1,777FollowersFollow

Most Popular

The North East Festival Will Be Held In Guwahati, Assam This Year

The North East Festival, a popular event held in Delhi's Indira Gandhi National Centre for the Arts ever since its inception seven years ago,...

India’s E-Commerce Industry Reported Nearly 56 Percent Growth This Festive Season

India's e-commerce industry reported nearly 56 percent growth in order volume this festive season amid the pandemic as compared to the same period last...

‘Operation Talwar’, A Story Of The Valour Of The Indian Navy

BY SHANTANOO MISHRA If the border of a country is secure, then both development and history can be created. All the three armies of India...

Indian American Teen Gitanjali Rao Is ‘Kid Of The Year’ By TIME Magazine

TIME magazine has put an Indian American teen "scientist and inventor" Gitanjali Rao on its first-ever 'Kid of the Year' cover, selected from a...

Christopher Nolan: Indian Films Are Wonderful And Are Kind Of Fundamental

Christopher Nolan feels Hindi films happen to retain the fundamental reasons due to which we enjoy cinema, and that Hollywood has lost some of...

Natural Antioxidants That Helps Body To Deal With Pollution

The air that we all are breathing has reached dangerous levels of pollution yet again. People with no known history of respiratory problems are...

A Focus On Academic Entrepreneurs In India

India is the third-largest tech start-up hub globally, yet academicians are still on the fringes when it comes to entrepreneurship in the country. The...

Indians Willing To Take Salary Cut To Work From Home

Amid the Covid-19 pandemic, at least 54 percent of working Indians said that they love working from home (WFH), of which 34 percent are...

Recent Comments