Tuesday June 18, 2019

Healthy lifestyle crucial for cancer prevention

0
//

New York: Offering a new explanation for what drives cancer, recent research has shown that cells with cancerous mutations can suddenly find themselves most fit, allowing their population to expand when the tissue ecosystem changes due to ageing, smoking, or other stressors. mother-491952_640

Arguing against the commonly held “accumulation of mutations” model of cancer, the study favors a model that depends on evolutionary pressures acting on populations of cells. It, therefore, contends that the ecosystem of a healthy tissue landscape lets healthy cells out compete ones with cancerous mutations.

This new thinking about what drives cancer development may have profound implications for cancer therapy and drug design.

“We have been trying to make drugs that target mutations in cancer cells,” said study senior author James DeGregori, associate director for basic science at University of Colorado Cancer Center in the US.

“But if it is the ecosystem of the body, and not only cancer-causing mutations, that allows the growth of cancer, we should also be prioritizing interventions and lifestyle choices that promote the fitness of healthy cells in order to suppress the emergence of cancer,” said DeGregori.

The proposed model, presented in the journal PNAS, helps to answer a longstanding question in cancer science known as Peto’s Paradox — if cancer is due to random activating mutation, larger animals with more cells should be at greater risk of developing the disease earlier in their lives.

Well, then why do mammals of vastly different sizes and lifespans all seem to develop cancer mostly late in life? The answer to this proposed by researchers is that in addition to activating mutation, cancer may require age-associated changes to the tissue landscape in order for evolution to favor the survival and growth of cancer cells over the competition from healthy cells.

Next Story

GRAIL Announces Significant Progress on Blood Tests to Detect Cancer

Grail's new results are from 2,300 people

0
GRAIL, Blood Tests, Detect, Cancer
FILE A patient has her blood drawn at a hospital in Philadelphia to monitor her cancer treatment. VOA

A California company says its experimental blood test was able to detect many types of cancer at an early stage and gave very few false alarms in a study that included people with and without the disease.

Many companies are trying to develop early detection “liquid biopsy” tests that capture bits of DNA that cancer cells shed into blood.

GRAIL, Blood Tests, Detect, Cancer
A California company says its experimental blood test was able to detect many types of cancer at an early stage. VOA

Grail’s new results are from 2,300 people. The test detected 55% of known cancers and gave false alarms for 1%. It also accurately suggested where the cancer may be about 90% of the time.

Also Read- US Removes Eritrea From Counterterror Non-Cooperaltion List

The company gave results in news release Friday and will report them Saturday at a conference in Chicago. They have not been published or reviewed by other scientists. (VOA)