Monday March 25, 2019

High carbohydrate intake may increase cancer recurrence risk

Five-year survival rates among these patients continue to be low, in part because these cancers are often detected in the later stages

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tumors
Can sugar contribute to growth of cancer in your body? Pixabay

Consuming high amounts of carbohydrates and sugar prior to treatment for head and neck cancer may increase the patients’ risks of cancer recurrence and mortality, a new study reports.

Patients who consumed the most total carbohydrates and sugars — in the form of sucrose, fructose, lactose and maltose — in the year preceding the cancer treatment were at greater risk of mortality from any cause during the follow-up period. Out of the 400 cancer patients in the study, published in the International Journal of Cancer, more than 17 per cent experienced recurrence of their cancer, and 42 patients died from it.

protein
Cancer can be caused by excessive intake of sugar and carbohydrates too. Pixabay

Associations among carbohydrate intake and patient outcomes differed by cancer type and stage, said lead author Anna E. Arthur, professor at the University of Illinois at Urbana-Champaign.

However, eating moderate amounts of fats and starchy foods such as whole grains, potatoes and legumes after treatment could have protective benefits, reducing the patients’ risks of disease recurrence and death, he added.

What We Know About Cancer Risk and Coffee

“Our results, along with the findings of other studies, suggest that diet composition can affect cancer outcomes,” said co-author Amy M. Goss, professor at the University of Alabama.

Higher mortality rates were found among people with oral cavity cancer who consumed the greatest amounts of total carbohydrates, total sugars and simple carbohydrates, but the researchers found no such associations among people who had oropharyngeal cancers.

Chronic diseases are not yet included in cancer prevention schemes.
Cancer can be caused due to too much sugar.

“Although in this study we found that higher total carbohydrate and total sugar were associated with higher mortality in head and neck cancer patients, because of the study design we can’t say that there’s a definitive cause-effect relationship,” Arthur said.

Five-year survival rates among these patients continue to be low, in part because these cancers are often detected in the later stages, putting patients at high risk of recurrence, the researchers said. IANS

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Next Story

Researchers Discover Balance of Two Enzymes That May Help Treat Pancreatic Cancer

While still in the earliest stages, Newton hoped this information might one day aid pancreatic diagnostics and treatment

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Cancer
Cancer Ribbon. Pixabay

A new research has set the stage for clinicians to potentially use levels of a pancreatic cancer patient’s PHLPP1 and PKC enzymes as a prognostic and for researchers to develop new therapeutic drugs that change the balance of the two enzymes as a means to treat the disease.

The study, published on Wednesday in Molecular Cell, was led by Alexandra Newton, professor in the Department of Pharmacology at the University of California, San Diego, School of Medicine, and Timothy Baffi, a graduate student in her lab, Xinhua news agency reported.

The new study built on the team’s work in 2015 that found the enzyme PKC, which was believed in previous studies to promote tumour growth, actually suppressed it.

The latest study took the investigation a step further by uncovering how cells regulate PKC activity and discovered that any time an over-active PKC is inadvertently produced, the PHLPP1 “proofreader” tags it for destruction.

Cancer patient
Cancer patient.

“That means the amount of PHLPP1 in your cells determines your amount of PKC,” Newton said. “And it turns out those enzyme levels are especially important in pancreatic cancer.”

The team observed 105 pancreatic cancer tumours to analyze the enzyme levels in each one. About 50 per cent of patients with low PHLPP1/high PKC lived longer than five-and-a-half years.

Also Read- A Brain Circuit Can Help Reverse Craving for Liquor, Says Study

While still in the earliest stages, Newton hoped this information might one day aid pancreatic diagnostics and treatment.

Pancreatic cancer is caused by the abnormal and uncontrolled growth of cells in the pancreas, a large gland in the digestive system. It typically doesn’t show symptoms in the early stages. Sufferers tend to develop signs, such as back pain and jaundice, when it has spread to other organs. (IANS)