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High thyroid hormone levels may up heart disease in elderly

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November1’2017:  Older adults with higher levels of a thyroid hormone may be at an increased risk of artery disease and consequent death, according to new research.

Free thyroxine (known as FT4) is a hormone produced by the thyroid gland that helps control the rate at which the body uses energy.

The findings showed that elderly with high levels of FT4 hormone may be at twice the risk of having high levels of coronary artery calcification scores, which may be an indicator of atherosclerosis — the process of progressive thickening and hardening of the walls of arteries from fat deposits on their inner lining.

“We expected that thyroid function would influence the risk of developing atherosclerosis by affecting cardiovascular risk factors such as blood pressure.

“However, our results remained very similar after accounting for several cardiovascular risk factors,” said lead author Arjola Bano, from Erasmus University in the Netherlands.

“This suggests that mechanisms other than traditional cardiovascular risk factors may play a role,” Bano added.

Further, increasing FT4 levels were associated with 87 per cent greater risk of suffering an atherosclerosis-related cardiovascular event as well as double the risk of atherosclerosis-related cardiovascular death.

“Our findings suggest that thyroid hormone FT4 measurement can help identify individuals at increased risk of atherosclerosis,” Bano said.

For the study, detailed in the journal Circulation Research, the team analysed data from 9,420 participants with an average age 65.

They looked at data on two types of hormones: thyroid-stimulating hormone and free thyroxine (known as FT4) and their link to atherosclerosis and death due to coronary heart disease, cerebrovascular disease or other artery-related illness.(IANS)

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Eat Vegetarian Diet to Ward Away Heart Disease

This is in contrast to the previous research that showed TMAO blood plasma levels -- and heart disease risk -- rise after the consumption of red meat and eggs, the researchers said

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Leafy vegetables. Pixabay

If you are suffering from high blood pressure, consuming fish, seafood and a primarily vegetarian diet may help reduce hypertension-related heart disease symptoms, a study suggests.

Intake of fish, seafood and vegetarian food increases levels of a compound called trimethylamine N-oxide (TMAO), known to boost heart health, said researchers from the Medical University of Warsaw in Poland.

The study showed that low-dose treatment with TMAO reduced heart thickening (cardiac fibrosis) and markers of heart failure in an animal model of hypertension.

“Our study provides new evidence for a potential beneficial effect of a moderate increase in plasma TMAO on pressure-overloaded heart,” the researchers said.

For the study, published in the American Journal of Physiology – Heart and Circulatory Physiology, researchers analysed the effect of TMAO on rats, which have a genetic tendency to develop high blood pressure.

One group of hypertensive rats were given low-dose TMAO supplements in their drinking water, and another group received plain water.

They were given the TMAO therapy for either 12 weeks or 56 weeks and were assessed for heart and kidney damage as well as high blood pressure.

Heart Attack, women
The study showed that low-dose treatment with TMAO reduced heart thickening (cardiac fibrosis) and markers of heart failure in an animal model of hypertension.
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The results showed that TMAO treatment did not affect the development of high blood pressure in any of the spontaneously hypertensive rats.

However, condition of the animals given the compound was better than expected, even after more than a year of low-dose TMAO treatment.

In addition, four- to five-fold increase in plasma TMAO does not exert negative effects on the circulatory system.

This is in contrast to the previous research that showed TMAO blood plasma levels — and heart disease risk — rise after the consumption of red meat and eggs, the researchers said.

Also Read- Women Rising Early Have Lower Risk of Breast Cancer

“It seems that a fish-rich and vegetarian diet, is associated with a significantly higher plasma TMAO than red meat-and egg-rich diets, considered to increase the cardiovascular risk,” the researchers noted.

“However, further study is needed to assess the effect of TMAO and TMA on the circulatory system.” (IANS)