Friday February 21, 2020

Hip and Knee Steroid Injections can be Harmful

Commonly given hip and knee steroid intra-articular injections may be harmful to some patients

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Study says, Commonly given hip and knee steroid intra-articular injections may be harmful to some patients with at-risk conditions. Pixabay

Commonly given hip and knee steroid intra-articular injections may be harmful to some patients with at-risk conditions, according to a new study.

Corticosteroid injections are often given to reduce pain and inflammation from osteoarthritis.

Researchers from Boston University have found accelerated arthritis and joint destruction can be the unintended result of intra-articular corticosteroid injections.

“We are now seeing that these injections can be very harmful to the joints with serious complications such as osteonecrosis, subchondral insufficiency fracture and rapid progressive osteoarthritis,” said study author Ali Guermazi, Professor at Boston University .

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Accelerated arthritis and joint destruction can be the unintended result of intra-articular cortico Steroid injections. Pixabay

“Intra-articular corticosteroid injection should be seriously discussed for pros and cons. Critical considerations about the complications should be part of the patient consent which is currently not the case right now,” he added.

Osteoarthritis of the hip and knee is among the most common joint disorders.

A frequently performed treatment for osteoarthritis and other joint related pain syndromes are intra-articular corticosteroid injections, yet there is conflicting evidence on their potential benefit.

For the study published in the journal Radiology, the researchers conducted a search on patients they had injected in the hips and knees during 2018.

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Cortico Steroid injections are often given to reduce pain and inflammation from osteoarthritis. Pixabay

They found that eight per cent had complications, with 10 per cent in the hips and four per cent in the knees.

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The researchers also suggest that the radiologic community should actively engage in high-quality research on this topic to better understand potential at-risk conditions prior to intervention, and to better understand potential adverse joint events following these procedures to avoid possible complications. (IANS)

Next Story

Here’s Why Too Short, Long Sleep Can Lead To Incurable Lung Disease

The researchers then showed, that pulmonary fibrosis is associated with short and long sleep duration using human data from the UK Biobank

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Our internal body clocks regulate nearly every cell in the human body, driving 24-hour cycles in many processes such as sleeping, hormone secretion and metabolism. Pixabay

People who regularly sleep for more than 11 hours or less than four hours are 2-3 times more likely to have the incurable lung disease, pulmonary fibrosis, compared to those that sleep for seven hours in a day, researchers have found.

They attribute this association to the body clock.

The study, published in the journal Proceedings of the National Academy of Sciences, also reveals that targeting the body clock reduces fibrosis in vitro, revealing a potential target for this incurable disease that kills about 5,000 people, a year in the UK,the same number as leukaemia.

“Pulmonary fibrosis is a devastating condition which is incurable at present. Therefore, the discovery that the body clock is potentially a key player potentially opens new ways to treat or prevent the condition,” said study lead author John Blaikley from The University of Manchester in UK.

“More work need to be done around studying the association between pulmonary fibrosis and sleep duration to establish both causation and reproducibility,” Blaikley said. “If these results are confirmed, then sleeping for the optimal time may reduce the impact of this devastating disease,” he added.

Our internal body clocks regulate nearly every cell in the human body, driving 24-hour cycles in many processes such as sleeping, hormone secretion and metabolism. In the lungs, the clock is mainly located in the main air carrying passages – the airways.

However, the team discovered that in people with lung fibrosis, these clock oscillations extend out to the small air spaces, called alveoli. Studies in mice revealed that by altering the clock mechanism it was possible to disrupt the fibrotic process making the animals more likely to develop pulmonary fibrosis.

The researchers then showed, that pulmonary fibrosis is associated with short and long sleep duration using human data from the UK Biobank.

The link between sleep duration and lung fibrosis is similar in strength to other known risk factors for this disease. People who report they regularly sleep four hours or less in a day doubled their chance of having pulmonary fibrosis while those sleeping 11 hours or longer in a day tripled their chance of having the disease, compared to those sleeping seven hours per day.

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People who regularly sleep for more than 11 hours or less than four hours are 2-3 times more likely to have the incurable lung disease, pulmonary fibrosis, compared to those that sleep for seven hours in a day, researchers have found. Pixabay

Smaller, but still elevated, risks were also seen in people who like to stay up late at night or those who do shift work. The researchers explain their findings by the discovery that a core clock protein (REVERBa) which alters the production of a key protein in lung fibrosis (collagen). This is an exciting finding, because chemical compounds can alter the function of REVERBa, said the researchers.

The researchers were able to show that one of these REVERBa compounds can reduce collagen in lung slices from people with this disease.

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The discovery that the clock plays a role in fibrosis suggests that altering these oscillations could become an important therapeutic approach, the research said. (IANS)