Friday, January 22, 2021
Home Life Style Health & Fitness Old Branch of Immune System May Influence Covid-19 Severity

Old Branch of Immune System May Influence Covid-19 Severity

Ancient part of immune system may underpin severe corona, as per researchers

One of the immune system’s oldest branches, called complement, may be influencing the severity of Covid-19 disease, say researchers.

The study, published in the journal Nature Medicine, found that people with age-related macular degeneration — a disorder caused by overactive complement — are at greater risk of developing severe complications and dying from Covid-19. The connection with complement suggests that existing drugs that inhibit the complement system could help treat patients with severe disease.

The authors also found evidence that clotting activity is linked to Covid severity and that mutations in certain complement and coagulation genes are associated with hospitalisation of Covid patients.

Follow NewsGram on Twitter to stay updated about the World news.

“Results provide important insights into the pathophysiology of Covid-19 and paint a picture for the role of complement and coagulation pathways in determining clinical outcomes of patients infected with SARS-CoV-2,” said study author Sagi Shapira from the Columbia University Vagelos in the US.

Ancient part of immune system may underpin severe corona
The authors also found evidence that clotting activity is linked to Covid severity. Pinterest

Coronaviruses are masters of mimicry, particularly with proteins involved in coagulation and proteins that make up a complement, one of the oldest branches of the human immune system, the researchers said. Complement proteins work a bit like antibodies and help eliminate pathogens by sticking to viruses and bacteria and marking them for destruction. Complement can also increase coagulation and inflammation in the body.

“Unchecked, these systems can also be quite detrimental. The new coronavirus — by mimicking complement or coagulation proteins — might drive both systems into a hyperactive state,” Shapira said.

According to the study, if complement and coagulation influence severity of COVID, people with pre-existing hyperactive complement or coagulation disorders should be more susceptible to the virus. That led the research team to look at Covid-19 patients with macular degeneration, an eye disease caused by overactive complement, as well as common coagulation disorders like thrombosis and haemorrhage.

Among 11,000 coronavirus patients with suspected Covid-19, the researchers found that over 25 per cent of those with age-related macular degeneration died, compared to the average mortality rate of 8.5 per cent and roughly 20 per cent required intubation.

Ancient part of immune system may underpin severe corona
Complement is said to be more active in obesity and diabetes. Pixabay

Also Read: Experts Advice: Be Careful of Fake Anti-Covid Drug Ads

“Complement is also more active in obesity and diabetes, and may help explain, at least in part, why people with those conditions also have a greater mortality risk from Covid-19, the authors wrote.

People with a history of coagulation disorders also were at increased risk of dying from Covid infection, they said.”I think our findings provide a stronger foundation for the idea that coagulation and complement play a role in Covid and will hopefully inspire others to evaluate this hypothesis and see if it’s something that can be useful for fighting the ongoing pandemic,” the team noted. (IANS)

STAY CONNECTED

19,120FansLike
362FollowersFollow
1,773FollowersFollow

Most Popular

People Following COVID Rules Due To Social Influence

People are more likely to follow Covid-19 restrictions based on what their friends do, rather than their own principles, a new study suggests. The findings...

Rise In Obesity Rates Due To Brain Pressure Disorder

A brain pressure disorder called idiopathic intracranial hypertension is on the rise, and the increase corresponds with rising obesity rates, a new study suggests. Idiopathic...

Prostate Cancer Can Be Detected By AI Through Urine

A novel Artificial Intelligence (AI)-based technique may help in diagnosing prostate cancer from the urine within only twenty minutes with almost 100 percent accuracy,...

Heart Disease Risk: Women Under 55 With Diabetes

Women, who are under 55, with Type-2 diabetes are at greater risk of developing coronary heart disease, a new study suggests. The study indicates...

Women Sailing Crew To Fight Against Marine Plastic Pollution

The Commonwealth Secretariat has signed a Memorandum of Understanding with 'eXXpedition', a non-profit organization that runs all-women sailing expeditions to research the causes of...

A screening Tool To Diagnose Depressive Symptoms In Early Pregnancy

Researchers have identified a screening tool that may help diagnose depressive symptoms and other mental disorders in early pregnancy. The study, published in the...

AI To Read The Facial Expressions Of Women In Distress

The Lucknow police are deploying facial recognition technology backed by security cameras that will read expressions of women in distress and alert their nearest...

Queer Spaces To Check Out In Philadelphia

In 1965, four years before the Stonewall Riots in New York ignited the worldwide modern gay rights movement, a group of protesters began an...

Recent Comments