Wednesday November 20, 2019

Increasing coffee intake bad for your brain : Study

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London: While drinking your daily cup of coffee can help you stay sharp, modifying your habit by increasing coffee consumption over time may increase risk of mild cognitive impairment (MCI), early symptoms of Alzheimer’s disease (AD) and dementia, says new research. 14599057004_9dc53af6f9_b

“These findings from the Italian Longitudinal Study on Ageing suggested that cognitively normal older individuals who never or rarely consumed coffee and those who increased their coffee consumption habits had a higher risk of developing MCI,” said one of the researchers Francesco Panza from the University of Bari Aldo Moro, Bari, Italy.

“Therefore, moderate and regular coffee consumption may have neuroprotective effects also against MCI – confirming previous studies on the long-term protective effects of coffee, tea, or caffeine consumption and plasma levels of caffeine against cognitive decline and dementia,” Panza noted.

The study involved 1,445 individuals aged 65-84 years.

An interesting finding in this study was that cognitively normal older individuals who modified their habits by increasing with time their amount of coffee consumption ( more than a cup of coffee/day) had about two times higher rate of MCI compared to those with reduced habits (less than a cup of coffee/day).

They also had about one and a half time higher rate of MCI in comparison with those with constant habits (neither more nor less than one cup of coffee/day).

Moreover, those who habitually consumed a moderate amount of coffee (one or two cups of coffee/day) had a reduced rate of the incidence of MCI than those who habitually never or rarely consumed coffee.

These findings were published in the Journal of Alzheimer’s Disease.

(IANS)

Next Story

Immune Cells Become Active and Repair Brain While Sleep: Study

For the findings, researchers conducted the study on mice

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Sleep
Study suggests that the enhanced remodeling of neural circuits and repair of lesions during Sleep may be mediated in part by the ability of microglia to dynamically interact with the Brain. Pixabay

Researchers have found that immune cells called microglia, which play an important role in reorganising the connections between nerve cells, fighting infections, and repairing damage, are also primarily active while we sleep.

Microglia serve as the brain’s first responders, patrolling the brain and spinal cord and springing into action to stamp out infections or gobble up debris from dead cell tissue.

“This research shows that the signals in our brain that modulate the sleep and awake state also act as a switch that turns the immune system off and on,” said study lead author Ania Majewska, Professor at University of Rochester in the US.

In previous studies, Majewska’s lab has shown how microglia interact with synapses, the juncture where the axons of one neuron connects and communicates with its neighbours.

The microglia help maintain the health and function of the synapses and prune connections between nerve cells when they are no longer necessary for brain function.

For the findings, researchers conducted the study on mice.

The current study points to the role of norepinephrine, a neurotransmitter that signals arousal and stress in the central nervous system.

This chemical is present in low levels in the brain while we sleep, but when production ramps up it arouses our nerve cells, causing us to wake up and become alert.

The study showed that norepinephrine also acts on a specific receptor, the beta2 adrenergic receptor, which is expressed at high levels in microglia.

When this chemical is present in the brain, the microglia slip into a sort of hibernation.

Sleep
Researchers have found that immune cells called microglia, which play an important role in reorganising the connections between nerve cells, fighting infections, and repairing damage, are also primarily active while we Sleep and affects Brain. Pixabay

The study, which employed an advanced imaging technology that allows researchers to observe activity in the living brain, showed that when mice were exposed to high levels of norepinephrine, the microglia became inactive and were unable to respond to local injuries and pulled back from their role in rewiring brain networks.

“This work suggests that the enhanced remodeling of neural circuits and repair of lesions during sleep may be mediated in part by the ability of microglia to dynamically interact with the brain,” said study first author Rianne Stowell.

ALSO READ: Scientists Link ‘Brain Fog’ to Body Illness

“Altogether, this research also shows that microglia are exquisitely sensitive to signals that modulate brain function and that microglial dynamics and functions are modulated by the behavioural state of the animal,” Stowell said.

The study was published in the journal Nature Neuroscience. (IANS)