Monday November 20, 2017

Indian Scientists suggest Tweaking Microbial Minions in the intestine to treat Pancreatitis

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Doctors operating on a patient (Representational Image), VOA

Kolkata, May 4, 2017: The gut is the gateway to heath, courtesy the teeming microbial minions. The smarter they are, the better you are.

Indian scientists say tweaking the bacterial milieu in the intestine could be potentially therapeutic in treating chronic pancreatitis, a disease that cripples the body’s ability to digest food and regulate blood sugar and could even lead to diabetes.

Their suggestion is based on the revelation that alteration in gut microbes may be linked to malnutrition and diabetes in chronic pancreatitis (CP) for which there is currently no definitive cure.

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“Whatever treatment is offered to these patients is directed in ameliorating or reducing pain and improving nutritional and glycemic (blood sugar) status,” Rupjyoti Talukdar, Clinicial Pancreatologist and Head of Pancreatic Research at Hyderabad’s Asian Institute of Gastroenterology, told IANS.

Some of the futuristic procedures that could potentially contribute to therapy include administration of “designer” probiotics and faecal transplantation.

“Our recent studies have added a new angle to the disease biology of CP, i.e. alteration of the gut microbiota could contribute to diabetes and malnutrition. Gut microbial manipulation, including ‘designer’ probiotics and faecal transplantation, could be a potential future therapeutic addendum,” Talukdar explained.

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“However, before translating the concept to the clinic, this needs to be stringently tested in clinical trials,” he cautioned.

It sounds incredible but the millions of microscopic bugs in our gut may have a major role to play in the progression of the disease.

Collective human gut micro flora is composed of a staggering 35,000 bacterial species.

A specific concoction of gut microbes is crucial for digestion of foods (such as breaking down complex carbohydrates), key to a normal immune system, fending off diseases and for producing many essential hormones and vitamins that the body cannot produce.

Whether the good ones triumph or the bad ones flourish, this good versus evil story unfolding in your belly determines your overall health.

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In chronic pancreatitis, as the pancreatic tissue is damaged, digestive juices reduce and the undigested fat piles up, things start spiralling south for microbes.

“When there is excess amount of undigested fat in the intestine, there will be a change in the profile of healthy bacteria,” Talukdar explained.

The study noted the reduction in numbers of two crucial bacterial species (F.Aprausnitzii and R. bromii) in individuals with CP. They are among the good bacteria needed to keep the tummy in top shape.

The gut flora is an entire ecological system by itself.

“Therefore by giving the entire intestinal flora in the form of faecal transplantation, the ecology will be maintained. This is important because the different groups of organisms in the intestine are interrelated in distribution and function,” Talukdar said.

Faecal transplant is a real thing and has already found beneficial use in diseases of the intestine, namely, Clostridium difficile diarrhoea, which could result from antibiotic use or other conditions such as ulcerative colitis.

The other futuristic option, Talukdar said could be “personalised” probiotics that would act on specific targets and thereby provide the maximum possible therapeutic benefit to the patient.

Talukdar underscored the importance of dietary interventions, besides therapy.

“It can be done to a certain extent by ensuring adequate fat digestion with pancreatic enzyme supplementation, taking a balanced home-cooked diet without any specific restriction while on enzyme supplementation, and otherwise avoid high fat content in diet so as to prevent accumulation of inadequately digested fat in the intestinal lumen,” he added.

The study, published in March in Nature’s Scientific Reports, is co-authored by Sai Manasa Jandhyala, A. Madhulika, G. Deepika, G. Venkat Rao, D. Nageshwar Reddy, Chivukula Subramanyam and Mitnala Sasikala. (IANS)

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Intake of Coffee can Reduce the risk of Death for Kidney Patients

Drinking Coffee may increase the lifespan of patients with chronic kidney disease.

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Drinking Coffee reduces mortality in Kidney patients
Drinking Coffee reduces mortality in Kidney patients. Pixabay
  • Want to live longer? Charge up on your cup of coffee. According to a study, caffeine consumption may prolong the lifespan of patients with chronic kidney disease (CKD).

Drinking coffee can Reduce mortality 

The findings showed a dose-dependent inverse association between caffeine and all-cause mortality.

People who had the highest intake of coffee had 24 percent lower risks of dying, while those in the second, third quartile of caffeine consumption had 12 percent and 22 percent lower risk.

“These results suggest that advising patients with CKD to drink more caffeine may reduce their mortality. This would represent a simple, clinically beneficial, and inexpensive option,” said Miguel Bigotte Vieira from Centro Hospitalar Lisboa Norte, in Portugal.

However, “this benefit should ideally be confirmed in a randomised clinical trial”, Vieira added.

For the study, the team examined the association of caffeine consumption with mortality among 2328 patients with CKD. The results will be presented at the ongoing ASN Kidney Week 2017 in New Orleans.

Moreover, this observational study cannot prove that drinking coffee reduces the risk of death in patients with CKD, but only suggests the possibility of such a protective effect, Vieira stressed.

Drinking coffee can also reduce diabetes risk, revealed a reported in the American Chemical Society Journal of Natural Products.(IANS)

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Health Benefits of eating more Whole Grains

Having a whole grain diet helps lose weight, as compared to refined grains -- rich in starch, gluten and devoid of natural fiber.

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Whole grains
Whole grains.Pixabay
  • Regularly consuming whole grain foods such as barley, brown rice, millet, oatmeal and rye may help lose weight
  • It also decreases the risk of heart disease and diabetes, a study has claimed.

Why should you eat more whole grains? Here is all you need to know

The findings showed that study participants who ate whole grains had less inflammation, particularly in overweight people, which increases the risk of developing Type 2 diabetes.

Further, participants were also found to eat less when whole grain products were on the menu because whole grain consumption causes satiety.

Importantly, having a whole grain diet helps lose weight, as compared to refined grains — rich in starch, gluten and devoid of natural fiber.

“Our analysis confirmed that there is a sound scientific basis for the dietary recommendation to eat whole grains. This may particularly apply to people who are at increased risk of developing cardiovascular disease or Type 2 diabetes,” said Tine Rask Licht, professor at the Technical University of Denmark.

Additionally, the researchers used DNA sequencing to analyze stool samples from the participants in order to examine whether the different diet types affected the participants’ gut bacteria composition.

Overall, the analysis did not show major effects of the dietary grain products on the composition of the lose weight.

“However, even though the analysis did not reveal significant changes in the average gut microbiota after whole grain consumption, it may well be that the individual components of our gut microbes has an impact on the individual reaction of our body to dietary whole grains,” Licht explained.

For the study, described in the journal Gut, the team included adults at risk of developing cardiovascular disease or Type 2 diabetes. The participants were divided randomly into two groups, with whole grain diet and refined varieties for eight weeks.(IANS)

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Are you suffering from Diabetes? Include these Fruits for your Diabetic Diet Plan

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Diabetes or diabetes mellitus occurs when the pancreas does not secrete enough insulin or when our cells become irresponsive to insulin. This results in the increase in blood glucose or blood sugar levels in your body.

  • A chronic disease like diabetes requires a strict diabetic diet with no cheat days.
  • The per day calorie intake ranges between 1500 to 1800 calories.
  • A diabetic diet plan should have at least three vegetables and two fruits per day. 

Include these relishing healthy fruits in your regular diabetic diet to maintain and treat your diabetes in a way which gives you essential balance in your taste.

Pomegranates

Diabetic Diet
Pomegranates are healthy for treating diabetes. Pixabay.

Acting as antioxidants, pomegranates serve as the best antidote for curing several chronic diseases. Pomegranate juice also helps to reduce the risk of cardiovascular diseases. The tiny red titbits should be added in your diabetic diet to maintain your blood circulation and blood sugar level.

Watermelon

Diabetic Diet
Add Watermelons in your diabetic diet to have a healthy heart. Pixabay.

The sugar content in watermelon is at a moderate level. It helps achieve a healthy combined mix of sugar and hydration if taken in controlled portions. It has a high water content, minerals, and fiber that will reduce your hunger by filling up your stomach with the required amount of water and sugar intake. To avoid overeating, you may add watermelon in your diabetic diet plan.

Strawberries

Diabetic Diet
Strawberries must form a major part of your diabetic diet. Pixabay.

Strawberries are a rich source of vitamin C, fibers, folate and manganese which must form a major part of your diabetic diet plan. They attain a low glycemic level that lowers the rate of release of blood glucose and maintains normal blood sugar level. It enhances immunity against diseases like cancer by increasing metabolism.

Kiwi

Diabetic diet
Eat kiwi and strawberry salad to have a healthy diabetic diet. Pixabay.

Kiwis also have a low glycemic level that does not increase the blood sugar level to a high extent. These are full of vitamin c and fibers that are capable of getting digested slowly. To maintain a healthy diabetic diet, kiwi’s would be beneficial to satisfy your tongue.

Apples

Diabetic diet
Apples in your diabetic diet will help you treat type 2 diabetes. Pixabay.

Undoubtedly, An apple a day keeps the doctor away. Apples are antioxidants filled with fibers that can treat diabetes in the best way. Apples are used to treat the risk of type 2 diabetes and should be counted up in your diabetic diet plan.

-Prepared by Bhavana Rathi of NewsGram. Twitter @tweet_bhavana