Thursday July 19, 2018

Indian Scientists suggest Tweaking Microbial Minions in the intestine to treat Pancreatitis

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Doctors operating on a patient (Representational Image), VOA
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Kolkata, May 4, 2017: The gut is the gateway to heath, courtesy the teeming microbial minions. The smarter they are, the better you are.

Indian scientists say tweaking the bacterial milieu in the intestine could be potentially therapeutic in treating chronic pancreatitis, a disease that cripples the body’s ability to digest food and regulate blood sugar and could even lead to diabetes.

Their suggestion is based on the revelation that alteration in gut microbes may be linked to malnutrition and diabetes in chronic pancreatitis (CP) for which there is currently no definitive cure.

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“Whatever treatment is offered to these patients is directed in ameliorating or reducing pain and improving nutritional and glycemic (blood sugar) status,” Rupjyoti Talukdar, Clinicial Pancreatologist and Head of Pancreatic Research at Hyderabad’s Asian Institute of Gastroenterology, told IANS.

Some of the futuristic procedures that could potentially contribute to therapy include administration of “designer” probiotics and faecal transplantation.

“Our recent studies have added a new angle to the disease biology of CP, i.e. alteration of the gut microbiota could contribute to diabetes and malnutrition. Gut microbial manipulation, including ‘designer’ probiotics and faecal transplantation, could be a potential future therapeutic addendum,” Talukdar explained.

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“However, before translating the concept to the clinic, this needs to be stringently tested in clinical trials,” he cautioned.

It sounds incredible but the millions of microscopic bugs in our gut may have a major role to play in the progression of the disease.

Collective human gut micro flora is composed of a staggering 35,000 bacterial species.

A specific concoction of gut microbes is crucial for digestion of foods (such as breaking down complex carbohydrates), key to a normal immune system, fending off diseases and for producing many essential hormones and vitamins that the body cannot produce.

Whether the good ones triumph or the bad ones flourish, this good versus evil story unfolding in your belly determines your overall health.

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In chronic pancreatitis, as the pancreatic tissue is damaged, digestive juices reduce and the undigested fat piles up, things start spiralling south for microbes.

“When there is excess amount of undigested fat in the intestine, there will be a change in the profile of healthy bacteria,” Talukdar explained.

The study noted the reduction in numbers of two crucial bacterial species (F.Aprausnitzii and R. bromii) in individuals with CP. They are among the good bacteria needed to keep the tummy in top shape.

The gut flora is an entire ecological system by itself.

“Therefore by giving the entire intestinal flora in the form of faecal transplantation, the ecology will be maintained. This is important because the different groups of organisms in the intestine are interrelated in distribution and function,” Talukdar said.

Faecal transplant is a real thing and has already found beneficial use in diseases of the intestine, namely, Clostridium difficile diarrhoea, which could result from antibiotic use or other conditions such as ulcerative colitis.

The other futuristic option, Talukdar said could be “personalised” probiotics that would act on specific targets and thereby provide the maximum possible therapeutic benefit to the patient.

Talukdar underscored the importance of dietary interventions, besides therapy.

“It can be done to a certain extent by ensuring adequate fat digestion with pancreatic enzyme supplementation, taking a balanced home-cooked diet without any specific restriction while on enzyme supplementation, and otherwise avoid high fat content in diet so as to prevent accumulation of inadequately digested fat in the intestinal lumen,” he added.

The study, published in March in Nature’s Scientific Reports, is co-authored by Sai Manasa Jandhyala, A. Madhulika, G. Deepika, G. Venkat Rao, D. Nageshwar Reddy, Chivukula Subramanyam and Mitnala Sasikala. (IANS)

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Diabetes? Living Near Woods May Cut Risk of Elevated Blood Sugar

The researchers hope that the findings will prompt doctors and other healthcare professionals to recommend patients to spend more time in greenery and natural areas

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Spending more time with nature also increased sleep duration and significantly reduced the levels of salivary cortisol -- a physiological marker of stress.
Spending more time with nature also increased sleep duration and significantly reduced the levels of salivary cortisol -- a physiological marker of stress. Pixabay

Feeling unwell? Instead of popping up a pill, sitting in the lap of nature can have various health benefits, says a study.

The findings showed that living near the nature or getting regular exposure to greenery may reduce the risk of a host of illnesses including Type-2 diabetes, cardiovascular diseases, high blood pressure, preterm birth and stress — and boost overall health.

“We often reach for medication when we’re unwell but exposure to health-promoting environments is increasingly recognized as both preventing and helping treat disease. Our study shows that the size of these benefits can be enough to have a meaningful clinical impact,” said Andy Jones from Britain’s University of East Anglia (UEA).

“People living near greenery likely have more opportunities for physical activity and socializing. Meanwhile, exposure to a diverse variety of bacteria present in natural areas may also have benefits for the immune system and reduce inflammation,” said lead author, Caoimhe Twohig-Bennett from UEA’s Norwich Medical School.

Health-boosting properties of forest bathing can be explained by Phytoncides, which are organic compounds with antibacterial properties, released by trees, the researchers said.
Health-boosting properties of forest bathing can be explained by Phytoncides, which are organic compounds with antibacterial properties, released by trees, the researchers said. Pixabay

For the study, published in the journal Environmental Research, the team studied data from over 140 studies involving more than 290 million people from 20 countries including the UK, the US, Spain, France, Germany, Australia and Japan.

Spending more time with nature also increased sleep duration and significantly reduced the levels of salivary cortisol — a physiological marker of stress.

Also Read: Air Pollution Linked to 3.2 Million New Diabetes Cases in One Year

The researchers hope that the findings will prompt doctors and other healthcare professionals to recommend patients to spend more time in greenery and natural areas.

“We hope that this research will inspire people to get outside more and feel the health benefits for themselves. Hopefully our results will encourage policymakers to invest in the creation, regeneration, and maintenance of parks and greenery, particularly in urban residential areas,” Twohig-Bennett noted. (IANS)

One response to “Diabetes? Living Near Woods May Cut Risk of Elevated Blood Sugar”

  1. Bad sugar. I found out I had type 2. I had no idea what to do or how I was going to eat. I did know that I was very motivated not to take medication. Then I read a diabetes story (google ” How I Freed Myself From Diabetes ” ) Eight weeks later I have lost 35 pounds and am not taking any medication and have a blood glucose reading that averages 105. The first few days saw an immediate change. I went from a blood glucose reading of 314 to 143 in three days. I immediately started shedding weight without exercise.