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Interesting Research! Frog Bacteria May Help Cure Fungal Infection Among Humans

"For amphibians, this is a promising study because there are only four chemically described bacterial secondary metabolites that inhibit chytrid fungi" 

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Frog
The research also holds promise for frogs, as the bacteria may help defy the chytridiomycosis epidemic, a major cause of disease-related deaths among amphibians worldwide, the researchers said. Pixabay

Frog skin bacteria may help develop alternative drugs to treat fungal infections that are becoming more drug-resistant in humans, finds a study.

The study showed that Pseudomonas Cichorii — a bacteria with antifungal properties living on frog’s skins — can potentially inhibit the growth of Aspergillus Fumigatus (A. Fumigatus) — a fungus that causes invasive aspergillosis — an infectious disease — in humans with impaired immune system.

The research also holds promise for frogs, as the bacteria may help defy the chytridiomycosis epidemic, a major cause of disease-related deaths among amphibians worldwide, the researchers said.

“We are showing to the scientific community a set of possible alternative molecules to fight fungal drug resistance in humans,” said lead author Christian Martin, from the Institute for Scientific Research and High Technology Services in Panama.

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This research has identified an antifungal compound produced by frog skin bacteria, which may be used to control pathogenic fungi affecting humans and amphibians. Pixabay

“Although more studies are needed, our collaboration could spark interest in conservation of amphibians as a novel source of bioactive compounds in humans.

“For amphibians, this is a promising study because there are only four chemically described bacterial secondary metabolites that inhibit chytrid fungi,” Martin said.

For the study, published in Scientific Reports journal, the team travelled to the Chiriqui highlands in Panama, where the chytrid fungus, responsible for the disease chytridiomycosis, has severely affected amphibian populations.

They collected samples from seven frog species to find out what kind of skin bacteria they harboured.

bacteria
“For amphibians, this is a promising study because there are only four chemically described bacterial secondary metabolites that inhibit chytrid fungi,” Martin said. Pixabay

In the laboratory, 201 bacterial strains were retrieved from the samples and tested against A. Fumigatus, in patients having an impaired immune system.

Of these, 29 showed antifungal activity, but particularly one bacterium called Pseudomonas Cichorii showed the greatest potential to inhibit the growth of A. Fumigatus.

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“I consider that bioprospecting compounds from skin secretions or bacteria living in frog’s skins is just the beginning,” said scientist Roberto Ibanez from the Smithsonian Tropical Research Institute in Panama City.

“This research has identified an antifungal compound produced by frog skin bacteria, which may be used to control pathogenic fungi affecting humans and amphibians. More research will be required to determine its potential medicinal use,” Ibanez said. (IANS)

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Mindfulness can Reduce Opioid Cravings, Study Says

Mindfulness is the meditative practice of focusing on the present moment and accepting one's thoughts, feelings and bodily sensations, without judgement.

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Mindfulness
Study Says, People suffering from opioid addiction and chronic pain might have fewer cravings and less pain if they use both Mindfulness techniques and Medication for opioid dependence. Pixabay

People suffering from opioid addiction and chronic pain might have fewer cravings and less pain if they use both mindfulness techniques and medication for opioid dependence, a new study said.

Mindfulness is the meditative practice of focusing on the present moment and accepting one’s thoughts, feelings and bodily sensations, without judgement.

According to the researchers, for many of those with opioid addictions who experienced chronic pain, anxiety and depression, methadone maintenance and mindfulness-based, non-drug interventions were promising treatments.

“Methadone maintenance therapy (MMT) has been an effective form of medication treatment for opioid use disorder,” said Nina Cooperman, Associate Professor at Rutgers University in the US.

“However, nearly half of individuals on MMT continue to use opioids during treatment or relapse with six months,” Cooperman said.

The study, published in the journal Drug and Alcohol Dependence, examined the effects of mindfulness and methadone therapy on 30 patients with opioid addiction and chronic pain.

Mindfulness
Mindfulness is the meditative practice of focusing on the present moment and accepting one’s thoughts, feelings and bodily sensations, without judgement. Pixabay

The findings showed that those who received methadone and a mindfulness training-based intervention were 1.3 times better at controlling their cravings and had significantly greater improvements in pain, stress and positive emotions, even though they were aware of more cravings than those who only received standard methadone treatment and counselling.

The researchers said that mindfulness-based interventions could help people dependent on opioids increase their self-awareness and self-control over cravings and be less reactive to emotional and physical pain.

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Individuals with an opioid addiction could also be taught to change their negative thoughts and savour pleasant events, which might help them to regulate their emotions. (IANS)