Sunday July 22, 2018

Isabelle Dinoire,world’s first partial face transplant recipient dies due to cancer

49 year old, face transplant recipient dies in April after succumbing to cancer

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Isabelle Dinoire, the woman who received the world's first partial face transplant with a new nose, chin and mouth, in an operation on Nov. 27, 2005 Source:VOA
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  • Isabelle Dinoire succumbed to cancer at the Amiens University Hospital
  • French doctors had stunned the world 11 years back by announcing they had given Dinoire a donor’s nose, lips, chin and parts of her cheek.
  • It is not clear if her illness was related to the transplant.

A Frenchwoman who received the world’s first partial face transplant has died, 11 years after the surgery that opened the way for dozens of other transplants worldwide.

The Amiens University Hospital in northern France announced Tuesday that Isabelle Dinoire succumbed to cancer in April.

Her family wanted the 49-year-old’s death kept private.

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The hospital did not release further details and it is not clear if her illness was related to the transplant.

But heavy use of immunosuppressant drugs had weakened her system.

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In 2005, French doctors Bernard Devauchelle and Jean-Michel Dubernard stunned the world by announcing they had given Dinoire a donor’s nose, lips, chin and parts of her cheek. She had been disfigured in a dog attack.

Dinoire’s partial face transplant sparked worldwide controversy. Critics questioned the ethics and the long-term consequences of the operation. (VOA)

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Why Exercise on Empty Stomach May be Better for Your Health

This is the first study to show that feeding prior to acute exercise affects post-exercise adipose tissue gene expression

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The study analysed effects of eating versus fasting on gene expression in adipose (fat) tissue in response to exercise. Pixabay

If you have been wondering whether it is better to eat or fast before a workout, researchers now have an answer. A new study has found that exercise on empty stomach is better for your health in the long term.

The study analysed effects of eating versus fasting on gene expression in adipose (fat) tissue in response to exercise.

After eating, adipose tissue “is busy responding to the meal and a bout of exercise at this time will not stimulate the same (beneficial) changes in adipose tissue”, explained corresponding author of the study Dylan Thompson from University of Bath in Britain.

“This means that exercise in a fasted state might provoke more favourable changes in adipose tissue, and this could be beneficial for health in the long term,” Thompson added.

“We propose that feeding is likely to blunt long-term adipose tissue adaptation to regular exercise,” the researchers noted in the study published in the American Journal of Physiology — Endocrinology and Metabolism.

The study participants were a group of overweight males who walked for 60 minutes at 60 per cent maximum oxygen consumption on an empty stomach and, on another occasion, two hours after consuming a high-calorie carbohydrate-rich breakfast.

The research team took multiple blood samples after eating or fasting and after exercising.

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Representational image. Pixabay

The researchers also collected fat tissue samples immediately before and one hour after walking.

Gene expression in the adipose tissue differed significantly in the two trials.

The expression of two genes, PDK4 and HSL, increased when the men fasted and exercised and decreased when they ate before exercising.

The rise in PDK4 likely indicates that stored fat was used to fuel metabolism during exercise instead of carbohydrates from the recent meal.

Also Read: Even Light Exercises Have Health Benefits

HSL typically increases when adipose tissue uses stored energy to support increased activity, such as during exercise, Thompson said.

These results reinforce the view that “adipose tissue often faces competing challenges,” Thompson wrote.

“This is the first study to show that feeding prior to acute exercise affects post-exercise adipose tissue gene expression,” the study said. (Bollywood Country)