Tuesday March 19, 2019

Isabelle Dinoire,world’s first partial face transplant recipient dies due to cancer

49 year old, face transplant recipient dies in April after succumbing to cancer

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Isabelle Dinoire, the woman who received the world's first partial face transplant with a new nose, chin and mouth, in an operation on Nov. 27, 2005 Source:VOA
  • Isabelle Dinoire succumbed to cancer at the Amiens University Hospital
  • French doctors had stunned the world 11 years back by announcing they had given Dinoire a donor’s nose, lips, chin and parts of her cheek.
  • It is not clear if her illness was related to the transplant.

A Frenchwoman who received the world’s first partial face transplant has died, 11 years after the surgery that opened the way for dozens of other transplants worldwide.

The Amiens University Hospital in northern France announced Tuesday that Isabelle Dinoire succumbed to cancer in April.

Her family wanted the 49-year-old’s death kept private.

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The hospital did not release further details and it is not clear if her illness was related to the transplant.

But heavy use of immunosuppressant drugs had weakened her system.

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In 2005, French doctors Bernard Devauchelle and Jean-Michel Dubernard stunned the world by announcing they had given Dinoire a donor’s nose, lips, chin and parts of her cheek. She had been disfigured in a dog attack.

Dinoire’s partial face transplant sparked worldwide controversy. Critics questioned the ethics and the long-term consequences of the operation. (VOA)

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New Finding! Scientists Have Developed Robotic Tool To Detect And Kill Cancer Cells in Humans

The researchers used their robotic system to study early-stage and later-stage bladder cancer cells. Previously, they had to extract the cell nuclei to examine it.

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The study, published in the journal Science Robotics, described the design in which a magnetic iron bead about 100 times smaller than the thickness of a human hair can be coaxed into any desired position within the cell, the Xinhua reported. Pixabay

Canadian scientists have developed a kind of magnetic tweezer that can precisely insert a minuscule bead robot into a live human cancer cell, pointing to a new option for diagnosing and killing cancer.

The study, published in the journal Science Robotics, described the design in which a magnetic iron bead about 100 times smaller than the thickness of a human hair can be coaxed into any desired position within the cell, the Xinhua reported.

The bead, about 700 nanometres in diameter, is placed on the microscope coverslip surrounded by six magnetic coils in different planes, and the cancer cell can swallow the bead into its membrane.

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They were able to measure how much stiffer the nucleus got when prodded repeatedly, and thus find out which cell protein or proteins might play a role in controlling this response, which could work as a new method of detecting cancer in early stage. Pixabay

Then, the researchers from University of Toronto controlled the bead’s position under a microscope, using a computer-controlled algorithm to vary the electrical current through coils and shaping the magnetic field in three dimensions.

The researchers used their robotic system to study early-stage and later-stage bladder cancer cells. Previously, they had to extract the cell nuclei to examine it.

The team measured cell nuclei in intact cells instead of breaking apart the cell membrane, showing that the nucleus is not equally stiff in all directions.

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In the later-stage cells, the stiffening response is not as strong as they are in the early stage, though both are seemingly similar, the researchers said. VOA

“It’s a bit like a football in shape. Mechanically, it’s stiffer along one axis than the other,” said Professor Sun Yu.

“We wouldn’t have known that without this new technique.”

They were able to measure how much stiffer the nucleus got when prodded repeatedly, and thus find out which cell protein or proteins might play a role in controlling this response, which could work as a new method of detecting cancer in early stage.

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In the later-stage cells, the stiffening response is not as strong as they are in the early stage, though both are seemingly similar, the researchers said.

Also, the team visualised using the tiny robots to either starve a tumour by blocking its blood vessels, or destroy it directly through mechanical ablation, although those applications are still a long way from clinical uses. (IANS)