Sunday August 25, 2019

Life-Threatening Liver Disease May be Caused Due To Fatty Diet: Study

Not only does this study define how fat and cholesterol shape the progression of liver inflammation and scarring, but it also identifies potential pathways

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Cholesterol -- a molecule normally linked with cardiovascular diseases -- may also play an important role in the onset and progression of Alzheimer's disease, researchers have found.
Junk Food is highly rich in Cholesterol, pixabay

High fat and high cholesterol diet may trigger changes in the immune system that can lead to a serious form of non-alcoholic fatty liver disease (NAFLD), a study warns.

An estimated 20 per cent of people with NAFLD have non-alcoholic steatohepatitis (NASH), according to the study published in the journal Hepatology.

NASH can eventually progress to cirrhosis or liver cancer, especially in those with obesity or Type 2 diabetes. Patients with NAFLD are also at an increased risk of cardiovascular disease, they said.

“Despite its increasing prevalence and burden to the health care system, there are currently no US Food and Drug Administration-approved therapies for non-alcoholic fatty liver disease,” said Hugo Rosen, a professor at University of Southern California in the US.

liver
Skip Oily Food in The Morning. Pixabay

“There’s an urgent need to better understand the causes of non-alcoholic fatty liver disease progression so that successful therapeutics can be designed and brought into clinical practice,” Rosen said.

The study illuminates how a toxic combination of dietary fat and cholesterol impacts the behaviour of macrophages, a type of white blood cell, in the liver.

Using a mouse model, the study details the cascade of events in the immune system that eventually leads to the type of liver inflammation and scarring that is commonly seen in patients with NASH.

After feeding mice diets with varying levels of fat and cholesterol, the team found that the combination of both had a synergistically detrimental action on the genes regulating liver inflammation and scarring.

Liver
The study illuminates how a toxic combination of dietary fat and cholesterol impacts the behaviour of macrophages, a type of white blood cell, in the liver.

Oxidised low-density lipoprotein cholesterol, in particular, directly altered gene expression in both human and mouse macrophages associated with inflammation and scar formation.

Also Read: Omega-3 Fatty Acids in Diet can Prevent Cancer From Spreading

The group also identified a novel type of reparative macrophage that counteracts the inflammation.

“Not only does this study define how fat and cholesterol shape the progression of liver inflammation and scarring, but it also identifies potential pathways that can be targeted for future therapies. That could bring us closer to finding a treatment for a disease that impacts millions of lives around the world,” Rosen said. (IANS)

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NRAI Tells Online Food Aggregators to Realign Their Offerings to Create Restaurant-Friendly Ecosystem

It was decided that all aggregators will rejig their features to detox the consumers from the addiction of deep discounts that has crippled the industry

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NRAI, Online, Food
In a meeting with the five top players -- Zomato, EazyDiner, Dineout, Magicpin and Nearbuy -- here, the industry body discussed how technology has a key role to play in driving engagement and discovery for retailers. Pixabay

In a bid to stop “unethical” deep discounting practices of online food aggregators amid nationwide #logout campaign, the National Restaurant Association of India (NRAI) on Tuesday told the platforms to realign their offerings to create a restaurant-friendly ecosystem, thus ending freebies and detox the consumers from discount addiction.

In a meeting with the five top players — Zomato, EazyDiner, Dineout, Magicpin and Nearbuy — here, the industry body discussed how technology has a key role to play in driving engagement and discovery for retailers versus deep discounting.

“It was decided that all aggregators will rejig their features to detox the consumers from the addiction of deep discounts that has crippled the industry,” the association said in a statement.

The meeting came after thousands of restaurants delisted from online food aggregators’ platforms across the country. The Federation of Hotel and Restaurant Associations of India (FHRAI) on Monday joined the chorus, calling for a review of the agreement of online food apps with restaurants and threatening nationwide protests.

NRAI, Online, Food
In a bid to stop “unethical” deep discounting practices of online food aggregators amid nationwide #logout campaign. Pixabay

Anshoo Sharma, Co-Founder & CEO, magicpin, said in a statement that they had a very productive discussion with the key members of NRAI.

“The NRAI members included President Rahul Singh (Beer Cafe), Priyank Sukhija (BoomBox, Lazeez Affaire, Flying Saucer and more), Vikrant Batra (Cafe Delhi Heights) and Nitin Saluja (Chaayos). We agreed on how technology has a key role to play in driving engagement and discovery for retailers versus deep discounting,’ said Sharma.

magicpin said it works at a base margin of 10 per cent and allows partners to top-up anywhere from Rs 2,000 to Rs 20 Lakh as per their marketing needs for the month while delivering guaranteed RoIs to them.

“We are fully supportive of NRAI’s cause and are looking forward to working together to create sustainable impact for its members through the use of technology,” Sharma added.

Also Read- Bose Launches Noise Cancelling Headphones 700 that Deliver Up To 20 Hours of Music

According to the FHRAI, restaurants are willing to do business with online food apps but the current policies need to be reconsidered.

“Restaurants are constantly but subtly threatened to participate in deep discounting schemes without respite through the year with one scheme getting replaced by another.

“Our members are neither given an option nor the opportunity to agree nor are they even consulted. Promises made while launching any new scheme is almost always broken by changing the rules itself,” said SK Jaiswal, Vice President of FHRAI.

Zomato’s Founder Deepinder Goyal had also requested restaurant owners to stop the #logout campaign. (IANS)