Monday December 16, 2019

Life-Threatening Liver Disease May be Caused Due To Fatty Diet: Study

Not only does this study define how fat and cholesterol shape the progression of liver inflammation and scarring, but it also identifies potential pathways

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Cholesterol -- a molecule normally linked with cardiovascular diseases -- may also play an important role in the onset and progression of Alzheimer's disease, researchers have found.
Junk Food is highly rich in Cholesterol, pixabay

High fat and high cholesterol diet may trigger changes in the immune system that can lead to a serious form of non-alcoholic fatty liver disease (NAFLD), a study warns.

An estimated 20 per cent of people with NAFLD have non-alcoholic steatohepatitis (NASH), according to the study published in the journal Hepatology.

NASH can eventually progress to cirrhosis or liver cancer, especially in those with obesity or Type 2 diabetes. Patients with NAFLD are also at an increased risk of cardiovascular disease, they said.

“Despite its increasing prevalence and burden to the health care system, there are currently no US Food and Drug Administration-approved therapies for non-alcoholic fatty liver disease,” said Hugo Rosen, a professor at University of Southern California in the US.

liver
Skip Oily Food in The Morning. Pixabay

“There’s an urgent need to better understand the causes of non-alcoholic fatty liver disease progression so that successful therapeutics can be designed and brought into clinical practice,” Rosen said.

The study illuminates how a toxic combination of dietary fat and cholesterol impacts the behaviour of macrophages, a type of white blood cell, in the liver.

Using a mouse model, the study details the cascade of events in the immune system that eventually leads to the type of liver inflammation and scarring that is commonly seen in patients with NASH.

After feeding mice diets with varying levels of fat and cholesterol, the team found that the combination of both had a synergistically detrimental action on the genes regulating liver inflammation and scarring.

Liver
The study illuminates how a toxic combination of dietary fat and cholesterol impacts the behaviour of macrophages, a type of white blood cell, in the liver.

Oxidised low-density lipoprotein cholesterol, in particular, directly altered gene expression in both human and mouse macrophages associated with inflammation and scar formation.

Also Read: Omega-3 Fatty Acids in Diet can Prevent Cancer From Spreading

The group also identified a novel type of reparative macrophage that counteracts the inflammation.

“Not only does this study define how fat and cholesterol shape the progression of liver inflammation and scarring, but it also identifies potential pathways that can be targeted for future therapies. That could bring us closer to finding a treatment for a disease that impacts millions of lives around the world,” Rosen said. (IANS)

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Women Who Consume Food Late in The Evening Likely to Suffer Heart Disease: Study

Data from the food diary completed by each woman was used to determine the relationship between heart health and the timing of when they ate

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Heart Health
Researchers found that, after 6 p.m. with every one per cent calories consumed Heart Health declines, especially for women. Pixabay

Women who consume a higher proportion of their daily calories late in the evening are more likely to be at risk of Heart Disease than women who do not, researchers have warned.

For the study, the research team assessed the cardiovascular health of 112 women using the American Heart Association’s Life’s Simple 7 measures at the beginning of the study and one year later.

Life’s Simple 7 represents the risk factors that people can improve through lifestyle changes to help achieve ideal cardiovascular health and include not smoking, being physically active, eating healthy foods and controlling body weight, along with measuring cholesterol, blood pressure and blood sugar levels.

A heart health score based on meeting the Life’s Simple 7 was computed.

“The preliminary results indicate that intentional eating that is mindful of the timing and proportion of calories in evening meals may represent a simple, modifiable behaviour that can help lower heart disease risk,” said study lead author Nour Makarem from Columbia University in the US.

During the study, participants of the study kept electronic food diaries by computer or cell phone to report what, how much and when they ate for one week at the beginning of the study and for one week 12 months later.

Data from the food diary completed by each woman was used to determine the relationship between heart health and the timing of when they ate.

Heart Disease
Women who consume a higher proportion of their daily calories late in the evening are more likely to be at risk of Heart Disease than women who do not, researchers have warned. Pixabay

Researchers found that, after 6 p.m. with every one per cent calories consumed heart health declined, especially for women.

These women were found more likely to have higher blood pressure, higher body mass index and poorer long-term control of blood sugar.

ALSO READ: Women Who Consume Food Late in The Evening Likely to Suffer Heart Disease: Study

Similar findings occurred with every one per cent increase in calories consumed after 8 p.m.

“It is never too early to start thinking about your heart health whether you’re 20 or 30 or 40 or moving into the 60s and 70s. If you’re healthy now or if you have heart disease, you can always do more. That goes along with being heart smart and heart healthy,” said study researcher Kristin Newby, Professor at Duke University. (IANS)