Friday November 22, 2019

Managing Cholesterol May Reduce The Risk of Alzheimer’s: Researchers

The researchers confirmed their findings in a large genetic study of healthy adults

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alzheimer's, cholesterol
One hemisphere of a healthy brain (L) is pictured next to one hemisphere of a brain of a person suffering from Alzheimer disease. VOA

Managing cholesterol might help reduce Alzheimer’s risk, says researchers, including one of Indian-origin, who identified a genetic link between the progressive brain disorder and heart disease.

Examining DNA from more than 1.5 million people, the study showed that risk factors for heart disease such as elevated triglyceride and cholesterol levels (HDL, LDL, and total cholesterol) were genetically related to Alzheimer’s risk.

However, genes that contribute to other cardiovascular risk factors, like body mass index and Type-2 diabetes, did not seem to contribute to genetic risk for Alzheimer’s.

Cognitive Impairment, cholesterol
Alzheimer’s disease patient Isidora Tomaz, 82, sits in an armchair in her house in Lisbon, Portugal. It’s predicted that by 2050, 135 million Americans are going to suffer from mild cognitive impairment, a precursor of Alzheimer’s. VOA

“The genes that influenced lipid metabolism were the ones that also were related to Alzheimer’s disease risk,” said Celeste M. Karch, Assistant Professor at the Washington University’s School of Medicine.

Thus, if the right genes and proteins could be targeted, it may be possible to lower the risk for Alzheimer’s disease in some people by managing their cholesterol and triglycerides, added Rahul S. Desikan, Assistant Professor at the UCSF.

For the study, published in the journal Acta Neuropathologica, the team

identified points of DNA that increase the risk of cardiovascular disease and also heighten the risk for Alzheimer’s disease.

alzheimer's, cholesterol
AI technique can boost brain scans to predict Alzheimer early. Pixabay

The team looked at differences in the DNA of people with factors that contribute to heart disease or Alzheimer’s disease and identified 90 points across the genome that were associated with risk for both diseases.

Their analysis confirmed that six of the 90 regions had very strong effects on Alzheimer’s and heightened blood lipid levels, including several within genes that had not previously been linked to dementia risk.

These included several points within the CELF1/MTCH2/SPI1 region on chromosome 11 that previously had been linked to the immune system.

Also Read: AI Technique to Improve Brain Scans To Predict Alzheimer’s Early

The researchers confirmed their findings in a large genetic study of healthy adults by showing that these same risk factors were more common in people with a family history of Alzheimer’s, even though they had not themselves developed dementia or other symptoms such as memory loss.

“These results imply that cardiovascular and Alzheimer’s pathology co-occur because they are linked genetically. That is, if you carry this handful of gene variants, you may be at risk not only for heart disease but also for Alzheimer’s,” Desikan said. (IANS)

Next Story

Vaping Can Lead to Chronic Disease in Lungs known as “Popcorn Injury”

This novel disease pattern of airway injury associated with vaping leading to chronic obstruction appears to be distinct from the alveolar injury

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Vaping
Novel disease pattern of airway injury associated with Vaping leading to chronic obstruction appears to be distinct from the alveolar injury characterizing the EVALI . Pixabay

In yet another serious health alert on e-cigarette use, researchers have documented first-ever case of a new form of damage from Vaping products in a youth which is similar to “popcorn lung,” a condition seen in workers exposed to food flavouring fumes in microwave popcorn factories.

If inhaled, the chemical called diacetyl causes bronchiolitis, which is characterized by the small airways of the lungs becoming inflamed and obstructed.

The 17-year-old patient who narrowly avoided the need for a double lung transplant suffered with this new type of vaping-related injury.

A team from Lawson Health Research Institute in London, Ontario, and University Health Network (UHN) in Toronto described the life-threatening bronchiolitis in a previously healthy 17-year-old male who initially presented for care after a week of persistent and intractable cough and was eventually hospitalized and put on life support.

After ruling out other causes, the team suspected flavoured e-liquids as the cause. The youth’s family reported that he vaped daily using a variety of flavoured cartridges and used tetrahydrocannabinol (THC) regularly. THC is the chemical responsible for most of marijuana’s psychological effects.

“This novel disease pattern of airway injury associated with vaping leading to chronic obstruction appears to be distinct from the alveolar injury characterizing the EVALI (e-cigarette or vaping product use-associated lung injury) have been described cases recently reported in the US, and the seven confirmed or probable cases in Canada, highlighting the need for further research and regulation of e-cigarettes,” elaborated lead author Dr Karen Bosma, Associate Scientist at Lawson.

The case study, published in CMAJ (Canadian Medical Association Journal), provides detailed medical information on the extent and type of injury as well as treatment.

“This case of life-threatening acute bronchiolitis posed a diagnostic and therapeutic challenge,” the authors wrote.

Vaping
In yet another serious health alert on e-cigarette use, researchers have documented first-ever case of a new form of damage from Vaping products in a youth which is similar to “popcorn lung,” a condition seen in workers exposed to food flavouring fumes in microwave popcorn factories. Pixabay

“Given the patient’s intense vaping exposure to flavoured e-liquid and negative workup for other causes of bronchiolitis, we suspected that bronchiolitis obliterans might have been developing in this patient as in microwave popcorn factory workers exposed to occupational inhalation of diacetyl.”

The youth narrowly avoided the need for a double lung transplant, but now has evidence of chronic damage to his airways.

ALSO READ: #GonnaTellMyKids Goes Trending on Twitter

He is still recovering from his lengthy stay in the intensive care unit, and is abstaining from e-cigarettes, marijuana and tobacco.

“This case may represent the first direct evidence of the lung disease most expected to result from e-cigarette use,” said Dr Matthew Stanbrook, Deputy Editor, CMAJ. (IANS)