Tuesday July 23, 2019

Managing Cholesterol May Reduce The Risk of Alzheimer’s: Researchers

The researchers confirmed their findings in a large genetic study of healthy adults

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alzheimer's, cholesterol
One hemisphere of a healthy brain (L) is pictured next to one hemisphere of a brain of a person suffering from Alzheimer disease. VOA

Managing cholesterol might help reduce Alzheimer’s risk, says researchers, including one of Indian-origin, who identified a genetic link between the progressive brain disorder and heart disease.

Examining DNA from more than 1.5 million people, the study showed that risk factors for heart disease such as elevated triglyceride and cholesterol levels (HDL, LDL, and total cholesterol) were genetically related to Alzheimer’s risk.

However, genes that contribute to other cardiovascular risk factors, like body mass index and Type-2 diabetes, did not seem to contribute to genetic risk for Alzheimer’s.

Cognitive Impairment, cholesterol
Alzheimer’s disease patient Isidora Tomaz, 82, sits in an armchair in her house in Lisbon, Portugal. It’s predicted that by 2050, 135 million Americans are going to suffer from mild cognitive impairment, a precursor of Alzheimer’s. VOA

“The genes that influenced lipid metabolism were the ones that also were related to Alzheimer’s disease risk,” said Celeste M. Karch, Assistant Professor at the Washington University’s School of Medicine.

Thus, if the right genes and proteins could be targeted, it may be possible to lower the risk for Alzheimer’s disease in some people by managing their cholesterol and triglycerides, added Rahul S. Desikan, Assistant Professor at the UCSF.

For the study, published in the journal Acta Neuropathologica, the team

identified points of DNA that increase the risk of cardiovascular disease and also heighten the risk for Alzheimer’s disease.

alzheimer's, cholesterol
AI technique can boost brain scans to predict Alzheimer early. Pixabay

The team looked at differences in the DNA of people with factors that contribute to heart disease or Alzheimer’s disease and identified 90 points across the genome that were associated with risk for both diseases.

Their analysis confirmed that six of the 90 regions had very strong effects on Alzheimer’s and heightened blood lipid levels, including several within genes that had not previously been linked to dementia risk.

These included several points within the CELF1/MTCH2/SPI1 region on chromosome 11 that previously had been linked to the immune system.

Also Read: AI Technique to Improve Brain Scans To Predict Alzheimer’s Early

The researchers confirmed their findings in a large genetic study of healthy adults by showing that these same risk factors were more common in people with a family history of Alzheimer’s, even though they had not themselves developed dementia or other symptoms such as memory loss.

“These results imply that cardiovascular and Alzheimer’s pathology co-occur because they are linked genetically. That is, if you carry this handful of gene variants, you may be at risk not only for heart disease but also for Alzheimer’s,” Desikan said. (IANS)

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Study: Intake of Dietary Supplements May do More Harm than Benefit

The doctor suggested that people should include more green vegetables in their diet

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dietary supplements
According to the study published in the journal Annals of Internal Medicine, supplements combining calcium and vitamin D may be linked to a slightly increased stroke risk. Pixabay

Researchers have found that intake of some vitamins, minerals and other dietary supplements may not benefit the heart and, in some cases, may even prove to be injurious.

According to the study published in the journal Annals of Internal Medicine, supplements combining calcium and vitamin D may be linked to a slightly increased stroke risk. However, there was no evidence that calcium or vitamin D taken alone had any health risks or benefits.

“Our analysis carries a simple message that although there may be some evidence that a few interventions have an impact on death and cardiovascular health, the vast majority of multivitamins, minerals and different types of diets had no measurable effect on survival or cardiovascular disease risk reduction,” said study lead author Safi U. Khan, Assistant Professor at the West Virginia University.

For the study, the researchers used data from 277 randomised clinical trials that evaluated 16 vitamins or other supplements and eight diets for their association with mortality or heart conditions including coronary heart disease, stroke and heart attack.

dietary supplements
“People should focus on getting their nutrients from a heart-healthy diet, because the data increasingly show that the majority of healthy adults don’t need to take supplements,” Michos said. Wikimedia Commons

They included data gathered on 992,129 research participants worldwide. The analysis showed possible health benefits only from a low-salt diet, omega-3 fatty acid supplements and possibly folic acid supplements for some people.

“The panacea or magic bullet that people keep searching for in dietary supplements isn’t there,” said senior author of the study Erin Michos from Johns Hopkins University School of Medicine in the US.

“People should focus on getting their nutrients from a heart-healthy diet, because the data increasingly show that the majority of healthy adults don’t need to take supplements,” Michos said.

According to Abhishek Singh, Consultant Cardiologist at Columbia Asia Hospital in Ghaziabad, dietary supplements do not have a measurably positive impact on cardiac health.

dietary supplements
The doctor suggested that people should include more green vegetables in their diet. Pixabay

“It’s more important to follow a healthy dietary regimen and avoid foods that are bad for the heart. Trans fatty acids are harmful and have to be curtailed. Refined sugars and simple carbohydrates are to be kept at a minimum,” Singh told IANS.

The doctor suggested that people should include more green vegetables in their diet. They are rich in vitamin K and dietary nitrates, which help protect the arteries and reduce blood pressure, he said.

ALSO READ: Fatal Drug Overdoses Decline in US; First Drop in Two Decades

“Studies like this raise concerns about harm from calcium and Vitamin D supplement use. As far as Vitamin D supplements (without calcium) are concerned, there has been no evidence on whether it has any impact on cardiovascular disease risk reduction,” Anupama Singh, Senior Consultant, Internal Medicine at Vimhans Nayati Super Specialty Hospital in Delhi, told IANS.

“The quality of the evidence base of these various nutritional supplements and dietary interventions still needs to be evaluated to ascertain the effectiveness of the study,” she added. (IANS)