Thursday, September 24, 2020
Home Life Style Health & Fitness Managing Cholesterol May Reduce The Risk of Alzheimer's: Researchers

Managing Cholesterol May Reduce The Risk of Alzheimer’s: Researchers

The researchers confirmed their findings in a large genetic study of healthy adults

Managing cholesterol might help reduce Alzheimer’s risk, says researchers, including one of Indian-origin, who identified a genetic link between the progressive brain disorder and heart disease.

Examining DNA from more than 1.5 million people, the study showed that risk factors for heart disease such as elevated triglyceride and cholesterol levels (HDL, LDL, and total cholesterol) were genetically related to Alzheimer’s risk.

However, genes that contribute to other cardiovascular risk factors, like body mass index and Type-2 diabetes, did not seem to contribute to genetic risk for Alzheimer’s.

Cognitive Impairment, cholesterol
Alzheimer’s disease patient Isidora Tomaz, 82, sits in an armchair in her house in Lisbon, Portugal. It’s predicted that by 2050, 135 million Americans are going to suffer from mild cognitive impairment, a precursor of Alzheimer’s. VOA

“The genes that influenced lipid metabolism were the ones that also were related to Alzheimer’s disease risk,” said Celeste M. Karch, Assistant Professor at the Washington University’s School of Medicine.

Thus, if the right genes and proteins could be targeted, it may be possible to lower the risk for Alzheimer’s disease in some people by managing their cholesterol and triglycerides, added Rahul S. Desikan, Assistant Professor at the UCSF.

For the study, published in the journal Acta Neuropathologica, the team

identified points of DNA that increase the risk of cardiovascular disease and also heighten the risk for Alzheimer’s disease.

alzheimer's, cholesterol
AI technique can boost brain scans to predict Alzheimer early. Pixabay

The team looked at differences in the DNA of people with factors that contribute to heart disease or Alzheimer’s disease and identified 90 points across the genome that were associated with risk for both diseases.

Their analysis confirmed that six of the 90 regions had very strong effects on Alzheimer’s and heightened blood lipid levels, including several within genes that had not previously been linked to dementia risk.

These included several points within the CELF1/MTCH2/SPI1 region on chromosome 11 that previously had been linked to the immune system.

Also Read: AI Technique to Improve Brain Scans To Predict Alzheimer’s Early

The researchers confirmed their findings in a large genetic study of healthy adults by showing that these same risk factors were more common in people with a family history of Alzheimer’s, even though they had not themselves developed dementia or other symptoms such as memory loss.

“These results imply that cardiovascular and Alzheimer’s pathology co-occur because they are linked genetically. That is, if you carry this handful of gene variants, you may be at risk not only for heart disease but also for Alzheimer’s,” Desikan said. (IANS)

STAY CONNECTED

19,143FansLike
362FollowersFollow
1,774FollowersFollow

Most Popular

Microsoft Study Shows Pandemic has Increased Feeling of Burnout Among Workers

If you've been feeling overwhelmed at work lately, you are not alone as a new Microsoft study has shown that the pandemic has increased...

Lower Zinc Levels in Blood Linked to Higher Death Risk in Covid Patients: Study

In a major study, researchers have found that having a lower level of zinc in the blood is associated with a poorer outcome in...

Time Magazine List of 100 Most Influential People: Ayushmann Khurrana Among 5 Indians

Indian actor Ayushmann Khurrana is in the Time magazine list of 100 Most Influential People this year. Follow NewsGram on LinkedIn to know what's happening...

Return to Usual Sexual Activity After Heart Attack for Long-Term Survival

Returning to usual levels of sexual activity within a few months after a heart attack is positively associated with long-term survival, say researchers. According to...

Researchers Find Potential New Drug Candidate Against Enterovirus

Some good news in the search for antiviral drugs for hard-to-treat diseases as researchers have identified a potential new drug candidate against enterovirus 71,...

Stroke Patients With Covid-19 Show Increased Inflammation, Death Rate: Researchers

Stroke patients who also have Covid-19 showed increased systemic inflammation, more serious stroke severity and a much higher rate of death, compared to stroke...

Playing Video Games in Childhood Can Improve Working Memory Years Later

In a good news to video game lovers, researchers have found that playing video games as a child can improve working memory years later. The...

Know the Negative Impact of Covid-19 Lockdown on Kids

Children, who appear at a relatively lower risk from Covid-19, are disproportionately harmed by precautions involved with lockdowns, warn researchers. Experts from Oxford University Hospitals...

Recent Comments