Monday December 17, 2018

Managing Cholesterol May Reduce The Risk of Alzheimer’s: Researchers

The researchers confirmed their findings in a large genetic study of healthy adults

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alzheimer's, cholesterol
One hemisphere of a healthy brain (L) is pictured next to one hemisphere of a brain of a person suffering from Alzheimer disease. VOA
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Managing cholesterol might help reduce Alzheimer’s risk, says researchers, including one of Indian-origin, who identified a genetic link between the progressive brain disorder and heart disease.

Examining DNA from more than 1.5 million people, the study showed that risk factors for heart disease such as elevated triglyceride and cholesterol levels (HDL, LDL, and total cholesterol) were genetically related to Alzheimer’s risk.

However, genes that contribute to other cardiovascular risk factors, like body mass index and Type-2 diabetes, did not seem to contribute to genetic risk for Alzheimer’s.

Cognitive Impairment, cholesterol
Alzheimer’s disease patient Isidora Tomaz, 82, sits in an armchair in her house in Lisbon, Portugal. It’s predicted that by 2050, 135 million Americans are going to suffer from mild cognitive impairment, a precursor of Alzheimer’s. VOA

“The genes that influenced lipid metabolism were the ones that also were related to Alzheimer’s disease risk,” said Celeste M. Karch, Assistant Professor at the Washington University’s School of Medicine.

Thus, if the right genes and proteins could be targeted, it may be possible to lower the risk for Alzheimer’s disease in some people by managing their cholesterol and triglycerides, added Rahul S. Desikan, Assistant Professor at the UCSF.

For the study, published in the journal Acta Neuropathologica, the team

identified points of DNA that increase the risk of cardiovascular disease and also heighten the risk for Alzheimer’s disease.

alzheimer's, cholesterol
AI technique can boost brain scans to predict Alzheimer early. Pixabay

The team looked at differences in the DNA of people with factors that contribute to heart disease or Alzheimer’s disease and identified 90 points across the genome that were associated with risk for both diseases.

Their analysis confirmed that six of the 90 regions had very strong effects on Alzheimer’s and heightened blood lipid levels, including several within genes that had not previously been linked to dementia risk.

These included several points within the CELF1/MTCH2/SPI1 region on chromosome 11 that previously had been linked to the immune system.

Also Read: AI Technique to Improve Brain Scans To Predict Alzheimer’s Early

The researchers confirmed their findings in a large genetic study of healthy adults by showing that these same risk factors were more common in people with a family history of Alzheimer’s, even though they had not themselves developed dementia or other symptoms such as memory loss.

“These results imply that cardiovascular and Alzheimer’s pathology co-occur because they are linked genetically. That is, if you carry this handful of gene variants, you may be at risk not only for heart disease but also for Alzheimer’s,” Desikan said. (IANS)

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The Young Miracle: Baby In Congo Suffering From Ebola Recovers

The latest WHO assessment, released Thursday, simply calls the circumstances "unforgiving."

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- In this photograph taken Dec. 3, 2018, and released by UNICEF, an Ebola survivor cares for one-week-old Benedicte who was infected at birth with the Ebola virus by her mother, at an Ebola treatment center in Beni, Democratic Republic of the Congo. VOA

They call her the “young miracle.” A baby who was admitted to an Ebola treatment center just six days after birth has now recovered from the virus.

Congo’s health ministry calls the baby the youngest survivor in what is now the world’s second-deadliest Ebola outbreak.

The ministry late Thursday tweeted a photo of the infant, swaddled and with her tiny mouth open in yawn or squall, surrounded by caregivers who watched over her 24 hours a day for weeks.

The baby’s mother, who had Ebola, died in childbirth, the ministry said.

The infant was discharged Wednesday from the treatment center in Beni. “She went home in the arms of her father and her aunt,” the ministry said.

 

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Health workers treat an unconfirmed Ebola patient, inside a MSF (Doctors Without Borders) supported Ebola Treatment Centre (ETC) in Butembo, Democratic Republic of the Congo, Nov. 3, 2018. VOA

 

Experts have reported high numbers of children with Ebola in this outbreak, which Congo’s health ministry says has 515 cases, 467 of them confirmed, including 255 confirmed deaths.

 

The tiny survivor is named Benedicte. In video footage shared by UNICEF, she is shown in an isolated treatment area, cradled in the arms of health workers in protective gear or cuddled by Ebola survivors, called “nounous,” who can go without certain gear such as masks. The survivors are crucial with their reassuring presence, the health ministry said.

“This is my first child,” her father, Thomas, said. “I truly don’t want to lose her. She is my hope.” He gazed at his baby daughter through the clear protective plastic.

Infected children

Children now account for more than one-third of all cases in this outbreak, UNICEF said earlier this week. One in 10 Ebola cases is in a child under 5 years old, it said, and children who contract the hemorrhagic fever are at greater risk of dying than adults.

Ebola, Baby
A health care worker carries a cross next to a coffin with a baby suspected of dying of Ebola in Beni, North Kivu Province of Democratic Republic of Congo, Dec. 13, 2018. VOA

While Ebola typically infects adults, as they are most likely to be exposed to the lethal virus, children have been known in some instances to catch the disease when they act as caregivers.

Few cases of Ebola in babies have historically been reported, but experts suspect transmission might happen via breast milk or close contact with infected parents. Ebola is typically spread by infected bodily fluids.

The World Health Organization also has noted that health centers have been identified as a source of Ebola transmission in this outbreak, with injections of medications “a notable cause.”

Dangerous conditions

So far, more than 400 children have been left orphaned or unaccompanied in this outbreak as patients can spend weeks in treatment centers, UNICEF said. A kindergarten has opened next to one treatment center in Beni “to assist the youngest children whose parents are isolated” there, it said.

Congo, Ebola, Women, Baby
Marie-Roseline Darnycka Belizaire, World Health Organization (WHO) Epidemiology Team Lead, talks to women as part of Ebola contact tracing, in Mangina, Democratic Republic of Congo. VOA

Health experts have said this Ebola outbreak, the 10th in Congo, is like no other as they face the threat of attack from armed groups and resistance from a wary population in a region that had never faced an Ebola outbreak before. Tracking suspected contacts of Ebola victims remains a challenge in areas controlled by rebels.

Also Read: Women Hit Especially Hard In Congo’s Worst Ebola Outbreak

The latest WHO assessment, released Thursday, simply calls the circumstances “unforgiving.”

And now, Congo is set to hold a presidential election Dec. 23, with unrest already brewing. (VOA)