Saturday February 24, 2018

Negligence of drug side effects data in India

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New Delhi: While 3.63 trillion medicines popped worldwide have a scientific reason for adverse side effects, India still remains the world’s third-largest medicine market.

In 2013, India reported no more than two percent of globally occurring adverse drug reactions (ADRs), jargon for side effects of medicines, logged in Vigibase, maintained by the Uppsala Monitoring Centre, a World Health Organisation collaborating centre for international drug monitoring.

India has equal side effects of medicines as in other countries.

According to a study in 2014, serious effects were seen in 6.7 percent of patients. Drug side effects have been sited as the reason for 3.4 percent of hospital admissions in India, 3.7 percent hospital readmission and 1.8 percent mortality. In the developed world, adverse reactions are believed to be the fourth-leading cause of death.

Within India, the ADR reporting rate (ADRs reported per million population) has almost doubled in the last three years to 40, but it is lower than 130

The reality is India has been ignoring the problem of adverse drug reactions or not reporting the data. That could prove costly, said experts, if it isn’t already.

Ignoring data makes drugs more unsafe.

Reporting the side effects of a drug could help determine if the medicine should stay or be pulled off shelves. A medicine labelled safe for clinical use after trials could still be found to be dangerous –as happened with Rofecoxib, a non-steroidal anti-inflammatory drug, a runaway success after its 1999 launch.

Between its launch and 2004, Rofecoxib reportedly caused between 88,000 and 140,000 cardiac events. This forced Merck, the drug’s maker, to voluntarily withdraw it from the US market and so was ban in India, although no significant cardiac event was reported.

In 2004, pharmacovigilance existed only on paper in India. Although formal monitoring began in 1986, and India signed up to the WHO Programme for International Drug Monitoring in 1997. Reporting was lax until the launch of the Pharmacovigilance Programme of India in 2010.

Carelessness and insensitivity are among reasons for India’s poor reporting of side effects.

Some key reasons behind India’s poor track record in reporting ADRs:

Nurses, who are most likely to see a patient suffering from a side effect, are expected to inform the treating doctor but seldom do.

“Doctors in India are careless in prescribing medicines because they know they will not be held accountable for their actions, and are equally careless about reporting ADRs,” said Kunal Saha, a US-based doctor who’s wife Anuradha Saha died of side effects of a drug overdose while treated for a skin allergy in 1998.

Settling Saha’s case, the Supreme Court ruled that medical negligence includes not informing patients about the possible side effects of a drug. “Physicians prescribe new drugs at the behest of medical representatives even without reading the drug pharmacology, driven by the promise of gifts, despite this being illegal,” said Saha. “Patients are prescribed excessive doses, unwarranted drugs or unwarranted combinations.”

Some doctors don’t know that drug side effects should be reported to any one of 150 ADR monitoring centres across India, nor are they adept at recognising a drug side effect.

Half of India’s population depends on drug stores not ran by pharmacists, and on doctors holding alternative medicine qualifications who aren’t permitted to prescribe allopathic medicines in many states.

Scarce data preclude regulatory action on questionable drugs

Drug side effects in India are scarcely reported, even in scientific literature.

A 65-year-old woman with cardiovascular disease developed chest pain after being put on Nimesulide, a popular pain-killer, for fracture-related pain, as this 2003 study reported. Swapping Nimesulide with an alternative, Ibuprofen, quickly alleviated the chest pain.

A 78-year-old man with heart disease was prescribed Nimesulide for a wrist injury. He developed breathlessness, blue pallor and restlessness, and quickly succumbed to further complications, another 2004 study reported.(IANS)

NewsGram view- In India a large number people suffer because of taking wrong medicines, even that has become a business that doctors don’t try to find the core of disease and prescribe medicine first. There should be data kept for drug side effects.

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Microsoft Surface Pro Now Available In India

There is a full-size glass trackpad with five-finger multi-touch capabilities that allows for ultimate precision and the keyboard is wrapped in soft Alcantara material

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Global chip-maker Qualcomm Technologies and Microsoft have collaborated with leading retailers from across the world to offer new "always connected" Windows 10 PCs powered by the Qualcomm Snapdragon Mobile PC Platform. Wikimedia Commons
  • Microsoft released its Surface Pro in India
  • It is a high-resolution tablet with 12.3-inch touch-display
  • Customers can buy the Surface Pro from a number of retailers in India

Microsoft on Thursday announced its Surface Pro notebook and accessories are available in India. Surface Pro features a high-resolution 12.3-inch “PixelSense” touch display that supports the new Surface Pen 4.

The first generation, 2-in-1 detachable of the Microsoft Surface series — with a configuration of Intel Core m3, 128 GB SSD, 4GB RAM and Intel HD Graphics 615 — will cost Rs 64,999.

Microsoft introduces its Surface Pro Indian markets. Wikimedia Commons
Microsoft introduces its Surface Pro Indian markets. Wikimedia Commons

Customers can buy the device through more than 130 commercial resellers, the company said in a statement.

“We are delighted to announce the launch of Surface Pro in India and offer our consumers another superior device that will enable them create, study, work and play virtually anywhere,” said Vineet Durani, Director, Windows and Devices, Microsoft India.

Also Read: Microsoft Announces Indian Languages Support For e-mail Addresses

With a new hinge that adjusts to 165 degrees, users can now put the device into “Studio Mode”, thus, creating the optimal position to write or sketch.

It also has a tilt functionality that detects the angle of the Surface Pen to enable more natural shading.

At 8.5-mm thickness and weighing 767 grams, the notebook packs the in 7th-generation Intel Core processor with a fanless design.

Surface Pro has a battery life of 13.5 hours. Wikimedia Commons
Surface Pro has a battery life of 13.5 hours. Wikimedia Commons

 

Its battery supports up to 13.5 hours of life.

There is a full-size glass trackpad with five-finger multi-touch capabilities that allows for ultimate precision and the keyboard is wrapped in soft Alcantara material. IANS