Monday December 16, 2019

New drug compound may reduce HIV potency

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Researchers have discovered that supplementing existing antiretroviral therapy with a natural compound can reduce the potency of the human immunodeficiency virus (HIV), thereby halting the progression of AIDS.

HIV-infected patients remain on antiretroviral therapy for life because the virus survives over the long-term in infected dormant cells. Interruption of current types of antiretroviral therapy results in a rebound of the virus and clinical progression to AIDS.

“OHIV_Virion-enur results highlight an alternative approach to current anti-HIV strategies,” said lead researcher Susana Valente, associate professor at The Scripps Research Institute (TSRI) in the US.

In the study published in the journal mBio, the researchers have detailed that unlike other antiretroviral therapies, a natural compound called Cortistatin A reduces residual levels of virus from the HIV-infected dormant cells, establishing a near-permanent state of latency and greatly diminishing the virus’ capacity for reactivation.

“Prior treatment with Cortistatin A significantly inhibits and delays viral rebound in the absence of any drug,” Valente noted.

“Our results suggest current antiretroviral regimens could be supplemented with a Tat inhibitor such as Cortistatin A to achieve a functional HIV-1 cure, reducing levels of the virus and preventing reactivation from latent reservoirs,” Valente explained.

For the study, the researchers isolated cells from nine HIV-infected participants being treated with antiretroviral drugs.

They found that treatment with the natural molecule reduced viral reactivation by an average of 92.3 percent. (IANS)

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More Than 7,000 People in Afghanistan Infected with HIV: WHO Report

Another HIV patient Omar, said: "If we go to hospitals and tell them that we have HIV Aids, they don't treat us."

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WHO
A study by WHO revealed that most of the European women with HIV are diagnosed at a late stage. Wikimedia Commons

Some 7,200 people in Afghanistan were estimated to be HIV positive, according to figures released by the the World Health Organization (WHO).

Marking World Aids Day, the WHO on Sunday called for a broader public awareness campaign in Afghanistan to deal with the issue, reports TOLO News.

But the Afghan Ministry of Public Health said that it registered only 2,883 cases of HIV in the country.

“According to our statistics, there are 2,883 cases of HIV registered in the country. The 7,200 cases reported by the World Health Organization are only an estimate,” said Fida Mohammad Paikan, deputy minister of public health.

AIDS and HIV
Stimulation of the wound healing response during early infection could have a protective effect against disease like AIDS from the HIV infection. Pixabay

Referring to factors behind the spread of the virus, Paikan said: “Last year the Ministry of Public Health registered 183 cases of HIV, and the figure has decreased to 150 new cases this year. But we need to undertake a comprehensive study to determine the exact number of those suffering from the disease.”

Victims however, have complained of social discrimination.

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Mohammad Idris, who contracted the disease from an infected needle during a drug injection, told TOLO News: “We are facing a lot of problems because we cannot share about our illness with others.”

Another HIV patient Omar, said: “If we go to hospitals and tell them that we have HIV Aids, they don’t treat us.” (IANS)

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