Tuesday October 23, 2018

New drug may treat depression in a day

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New York: Researchers have identified promising drug compounds that could successfully treat depression in less than 24 hours while minimizing side effects.

Although they have not yet been tested on people, the compounds could offer significant advantages over current antidepressant medications, the study said.

“Our results open up a whole new class of potential antidepressant medications,” said lead researcher Scott Thompson, professor at the University of Maryland School of Medicine in the US. depression

“These compounds can relieve the devastating symptoms of depression in less than one day and can do so in a way that limits some of the key disadvantages of current approaches,” Thompson said in the study published in the journal Neuropsychopharmacology.

These compounds, called GABA-NAMs, minimise unwanted side effects because they are precise: they work only in the parts of the brain that are essential for mood, the study said.

The compounds were tested in rats that were subjected to chronic mild stress and caused the animals to act in ways that resemble human depression.

Giving stressed rats GABA-NAMs successfully reversed experimental signs of a key symptom of depression, anhedonia, or the inability to feel pleasure.

Remarkably, the beneficial effects of the compounds appeared within 24 hours – much faster than the multiple weeks needed for most of the currently available antidepressants called selective serotonin re-uptake inhibitors, or SSRIs to produce the same effects.

“These compounds produced the most dramatic effects in animal studies that we could have hoped for.”

“It will be exciting to find out whether they produce similar effects in depressed patients. If these compounds can quickly provide relief of the symptoms of human depression, such as suicidal thinking, it could revolutionise the way patients are treated,” Thompson said.

No effects of the compound were detected in unstressed animals, raising hopes that they will not produce side effects in human patients.

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Anaemia Drug Can Aid in Recovery After Heart Attack

However, further studies will be needed to confirm if the same benefits are seen in humans, they noted

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Heart Disease
Concern has often focused on the toxicity or carcinogenic properties of the metals, particularly at high doses. Pixabay

Drugs currently undergoing development to treat anaemia — lack of blood — could be repurposed to help prevent people with Type-2 diabetes from developing heart failure, according to a new research.

Researchers found that after a heart attack, a protein called HIF acts to help heart cells survive.

In people with diabetes, fats accumulate within the heart muscle and stop the HIF protein from becoming active. This means that a person is more likely to suffer lasting heart muscle damage, and develop heart failure after a heart attack.

“After a heart attack, people with Type-2 diabetes are more likely to develop heart failure more quickly, but we have not fully understood the reasons why that is the case,” said lead researcher Lisa Heather, research student at the University of Oxford in the UK.

“What we have shown with this research is that the metabolism of people with Type-2 diabetes means they have higher levels of fatty acids in the heart. This prevents signals going to the heart protective protein telling it to ‘kick-in’ after a heart attack,” she added.

Representational image.
Representational image. (IANS)

In the study, published in the Journal of the American College of Cardiology, the team treated diabetic rats with a drug known to activate the HIF protein, and were able to encourage the heart to recover after a heart attack.

However, these initial results suggest that several drugs known to activate HIF and currently undergoing phase-III clinical trials to treat people with anaemia, could potentially be given to people with diabetes, immediately after a heart attack in the future, the researchers said.

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“This research in rats has not only identified the mechanism that could explain why people with Type-2 diabetes have poorer outcomes after a heart attack, but also a practical way this might be prevented,” the researchers explained.

However, further studies will be needed to confirm if the same benefits are seen in humans, they noted. (IANS)

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