Friday April 27, 2018

New HIV vaccine candidate may generate immune response: Study

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Washington: An experimental vaccine candidate may have the potential to stimulate the immune system to block HIV infection, according to new research.Symptoms_of_acute_HIV_infection

The findings may represent a leap forward in the effort to develop a vaccine against HIV, which has so far struggled to elicit antibodies that can effectively fight off different strains of the virus, according to three papers published on Thursday in the US journals Cell and Science.

“The results are pretty spectacular,” said Dennis Burton of the Scripps Research Institute (TSRI), who led one of the studies, Xinhua reported.

Currently, many vaccines use a dead or inactive version of the disease-causing microbe itself to trigger antibody production, but immunisations with “native” HIV proteins are ineffective in triggering an effective immune response, due to HIV’s ability to evade detection from the immune system and mutate rapidly into new strains.

This challenge has led many researchers to believe that a successful AIDS vaccine will need to consist of a series of related but slightly different proteins called immunogens (substances that induce a specific immune response) to train the body to produce broadly neutralising antibodies, a special class of immune system molecules that can bind to and neutralise a wide range of globally occurring HIV variants.

In the new studies, the researchers tested one of these potential proteins, an immunogen called eOD-GT8 60mer, which would bind to and activate B cells needed to fight HIV.

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Using a technique called B cell sorting, the researchers showed that immunisation with eOD-GT8 60mer caused two different mouse models to produce antibody “precursors”, which have some of the traits necessary to recognise and block HIV infection.

This suggested that eOD-GT8 60mer could be a good candidate to serve as the first in a series of immunisations against HIV, the researchers said.

The US National Institutes of Health has funded the research. (IANS)

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Top 3 Ways To Promote Faster Fat Loss

In this article, we’ll show you the top 3 ways that you can promote faster fat loss, just in time for summer.

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Ways To Promote Faster Fat Loss
Ways To Promote Faster Fat Loss. Pixabay

You might be sitting there unhappy with your body right now. And let’s be honest, summer
Is just around the corner! So instead of being unhappy, it only takes a few lifestyle changes and actions to sculpt your dream body or figure – so you can walk around on the beach without feeling embarrassed.
In this article, we’ll show you the top 3 ways that you can promote faster fat loss, just in
time for summer.

Eat More Thermogenics

Everyone knows that you need to watch your calories to lose weight. If you eat more
calories than your TDEE (total daily energy expenditure), then you’ll put on weight – that’s a fact. First thing’s first. Watch your calorie intake!
But most people know this. So, the second thing you can do is help your body burn more
calories.

Eat more Thermogenics.
Eat more Thermogenics. Pixabay

How do you do this? Answer: eat more thermogenic nutrients.
Just to clear things up, thermogenics are foods that raise your body temperature and heart- rate, so your body works harder to cool itself back down. In the process, your body burns more calories, even while you’re sat on the computer on social media!
Not bad eh? Well, here’s a small list of the best thermogenics, according to fitness experts, LeanBulking.com:

 Chili Peppers
 Green Tea
 Chlorogenic acid (in green coffee beans)
 Chromium Picolinate (naturally found in broccoli)
 Caffeine

Also Read: Obesity may affect a child’s liver

HIIT (High Intensity Interval Training)

When many people think about the gym, they imagine themselves running on a treadmill
for hours; this seems both seriously boring and time-consuming.
The good news is that you don’t need to do this. . In fact, a study by Stephen H. Boucher
proved that a short 20 minute HIIT can really help you shed body fat.

High Intensity Interval Training
High Intensity Interval Training. Pixabay

What is HIIT? It’s when you sprint for a short period of time, then have a rest period, before starting the process again for around 20-30 minutes. You can perform this on a treadmill or cycle machine. Or you can get the job done outside in a park!
Not only that, HIIT session benefits you after the session too; studies have also shown that HIIT induces an ‘afterburn’ effect, which boosts your metabolism for up to 24 hours
afterwards too – promoting even more fat loss.
So next time you’re short of time or just want a quicker, more efficient workout, then
perform a 20-30 minute HIIT session to sweat off some body fat.

Also Read: Obesity Linked To Heart Rhythm Disorder

Lift Weights!

Back in the 1960s-80s, weightlifting was considered strange. People just couldn’t
understand why men and women would spend hours in the gym training.
But guess who came out of this period successful? The likes of Arnold Schwarzenegger and
Lou Ferrigno, that’s who!
Now, luckily more and more people know the benefits of lifting weights. And it’s great that
we live In an age where more and more women are beginning to squat with heavier weights too. This is also why there are so many Instagram Fitness Models finding fame in recent times. Ultimately, as well as helping you improve the appearance of your body, weightlifting has and improve your heart health more than running. You can’t argue with that!

Lift Weights
Lift Weights. Pixabay

Conclusion
Weight loss isn’t easy to achieve. But you can make easy changes to your lifestyle to help
you achieve that toned body you’ve dreamed about having.
Making these changes isn’t just for your vanity either. Eating healthier and training in the
gym will really improve your general health, mood and self-confidence too.
So add a few chilies to more meals, waste less time in the gym by performing HIIT, and start a sensible weight-lifting program. You might be surprised by how fast you begin losing those unwanted pounds!