Friday April 27, 2018

New male birth control pill found safe and effective

All participants passed safety tests, including markers of liver and kidney function, the study said

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Opioids
Male contraceptives proved safe and effective.
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  • Researchers have found oral contraceptive for males
  • The experiment has been successful
  • The pills are effective and successful in their operation

In a major step forward in the development of a once-daily “male pill”, researchers have found an experimental oral contraceptive to be safe in men with hormone responses consistent with effective contraception.

The findings presented at the Endocrine Society’s annual meeting in Chicago showed that the new pill — called dimethandrolone undecanoate, or DMAU — appears to be safe when used daily for a month.

The pills are effective with no harmful effects. Wikimedia commons

Like the pill for women, DMAU combines activity of an androgen (male hormone) like testosterone, and a progestin, and is taken once a day, said the study’s senior investigator, Stephanie Page, Professor of Medicine at the University of Washington in Seattle.

“Many men say they would prefer a daily pill as a reversible contraceptive, rather than long-acting injections or topical gels, which are also in development,” Page pointed out.

Progress toward a male birth control pill has been stymied because, according to Page, available oral forms of testosterone may cause liver inflammation, and they clear the body too quickly for once-daily dosing, thus requiring two doses a day.

Also Read: Injectable Male Contraceptive likely to Lower Unwanted Pregnancies

However, DMAU contains undecanoate, a long-chain fatty acid, which Page said slows this clearance. The study included 100 healthy men between ages 18 and 50 years. The investigators tested three different doses of DMAU — 100, 200, and 400 milligrams, or mg.

A total of 83 men completed the study, including giving blood samples for hormone and cholesterol testing on the first and last day of the study.

At the highest dose of DMAU tested, 400 mg, participants showed “marked suppression” of levels of their testosterone and two hormones required for sperm production. The low levels, Page said, were consistent with effective male contraception shown in longer-term studies.

These pills are revolutionary in the world of contraceptives.

“Despite having low levels of circulating testosterone, very few subjects reported symptoms consistent with testosterone deficiency or excess,” Page said.

All groups taking DMAU did have weight gain and decreases in HDL (high-density lipoprotein, or “good”) cholesterol, both of which Page said were mild.

All participants passed safety tests, including markers of liver and kidney function, the study said. “These promising results are unprecedented in the development of a prototype male pill,” Page said. “Longer term studies are currently underway to confirm that DMAU taken every day blocks sperm production,” she added. IANS

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Cycling responsible for maximum fractures in males: Study

The incidence of injuries in males was 1.7 times higher for neck sprains and 3.6 times greater for fractures when compared to females

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Cycling causes most fractures in men. VOA
Most fractures in men are caused by cycling. VOA
  • Cycling is healthy
  • But it also causes maximum fractures in males
  • The most common injury is spinal injury

While regular cycling has been associated with various health benefits, including a healthy heart, bones as well as decrease in body fat, a new study has shown that the recreational sport is the number one cause of cervical fractures in men.

The findings showed that sporting-related cervical fractures increased by 35 per cent from 2000 to 2015, mainly due to an increase in cycling-related injuries.

Cycling causes maximum fractures in men.
Cycling causes maximum fractures in men.

Men experienced the most fractures due to cycling, while the most common cause of fractures in women was horseback riding.

“Cervical spine injury is a substantial cause of morbidity and mortality, and, as far as injuries go, one of the more devastating injuries that we as orthopaedic surgeons can treat,” said lead author J. Mason DePasse, from the Brown University in Rhode Island, US.

“Our study showed that cycling is the number one cause of neck fractures, which suggests we may need to investigate this in terms of safety,” DePasse added.

For the study, the team examined 50,000 patient cases in the national database to estimate the sex-specific incidence of cervical spine injuries in sporting activities and to identify the activities most commonly associated with neck sprains and cervical fractures.

The study authors identified 27,546 patients who sustained a neck injury during a sporting activity. Overall, the number of neck sprains decreased by 33 per cent from 2000 to 2015; however, sprains sustained during weightlifting and aerobic exercise increased 66 per cent.

Cycling is a very healthy exercise yet it can be harmful if not done properly. Pixabay
Cycling is a very healthy exercise yet it can be harmful if not done properly. Pixabay

Sporting-related cervical fractures increased by 30 per cent in that time period, which was driven in part by a 300 per cent increase in cycling-related injuries.

The incidence of injuries in males was 1.7 times higher for neck sprains and 3.6 times greater for fractures when compared to females. The findings were presented at the 2018 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS) in New Orleans. IANS