Friday December 6, 2019

New Sleeping Pill Can Help Patients Wake up in Response to Threat

However, more studies on humans are needed to confirm DORA safety and efficacy, they noted

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Pills (representational Image), Pixabay

Japanese scientists have shown that a new class of sleeping pill that preserves the ability to wake in response to a threat, unlike the commonly prescribed drugs that muffles a sleeping brain’s “intruder alert”.

Even during sleep the brain continuously processes sensory information, waking us if it detects a threat. But the most widely prescribed class of sleeping pills, known as benzodiazepines, makes us less likely to rouse in response to sensory input.

The findings showed that millions prescribed on these sleeping pills would sleep through a fire alarm as someone vacuuming next to their bed.

 However, the new class of drugs called dual orexin receptor antagonists (DORAs) more selectively targeted the brain’s sleep or wake pathways, which gives them safety advantages over benzodiazepines, said researchers from the Kagoshima University.

These include a reduced “hangover effect”, with DORAs less likely to affect driving ability the day after use.

“Benzodiazepines stimulate the widespread brain receptor GABA-A, which makes us sleepy but also suppresses off-target brain areas – including the ‘gatekeeper’ that decides which sensory inputs to process,” explained author Tomoyuki Kuwaki, Professor at the varsity.

Contraception, Men
New sleeping pill can help patients wake up in response to threat.

In the study, published in Frontiers in Behavioral Neuroscience journal, mice that were given the new experimental hypnotic drug DORA-22 wake as quickly when threatened as drug-free sleepers — and then fall back asleep as quickly as ones given standard sleeping pills, once the threat is gone.

While DORA-22 allows mice to wake to a threat, it still helps them sleep.

Thus, the selectivity of DORAs could make them a safer alternative during sleep as well — by allowing the brain’s sensory gatekeeper to stay vigilant to threats, the researchers said.

Also Read- Here’s What Causes Cancer in Children

However, more studies on humans are needed to confirm DORA safety and efficacy, they noted.

“Although it remains to be seen whether DORAs have the same properties when used in humans, our study provides important and promising insight into the safety of these hypnotics,” Kuwaki said. (IANS)

Next Story

Resistance to Antibiotics Rise Among Indian Patients in Pace

There is increase in resistance to antibiotics including clarithromycin which is undoubtedly a worrisome situation in the country

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Antibiotics
In India, a huge population prefers to consume over-the-counter (OTC) drugs without even consulting a doctor. In the long run, this may make them resistant to most of the Antibiotics including clarithromycin. Pixabay

Resistance to commonly-used Antibiotics like clarithromycin is rising among Indian patients and that too at quite a fast pace, health experts have warned.

Clarithromycin is used to treat a wide variety of bacterial infections. This medication can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers.

According to the World Health Organization (WHO), antibiotic resistance is one of the biggest threats to global health, food security and development today.

Sunil Sofat, Additional Director, Department of Interventional Cardiology (Adult) at Jaypee Hospital in Noida, said that every antibiotic medicine has its own mechanism to treat diseases.

“Yes, this is true that the resistance to clarithromycin is rising among the Indian patients and that too at quite a fast pace. There are multiple factors for the same but one of the major reasons behind it is self-medication,” Sofat told IANS.

“In India, a huge population prefers to consume over-the-counter (OTC) drugs without even consulting a doctor. In the long run, this may make them resistant to most of the antibiotics including clarithromycin,” Sofat added.

Antibiotics
Resistance to commonly-used Antibiotics like clarithromycin is rising among Indian patients and that too at quite a fast pace, health experts have warned. Pixabay

In a recent study presented at United European Gastroenterology (UEG) Week Barcelona 2019, researchers have found that resistance to clarithromycin, one of the most established antimicrobials used to eradicate Helicobacter pylori (H. pylori), had increased from 9.9 per cent in 1998 to 21.6 per cent last year, with increases in resistance also seen for levofloxacin and metronidazole.

The study, which analysed 1,232 patients from 18 countries across Europe, investigated resistance to antibiotics regularly taken for Helicobacter pylori infection, a harmful bacterium associated with gastric ulcers, lymphoma and gastric cancer.

According to Gaurav Jain, Senior Consultant, Internal Medicine at Dharamshila Narayana Superspeciality Hospital, New Delhi, antibiotic resistance is a major concern.

“In India the consumption of antibiotics without consulting a qualified physician is quite common which is leading to its resistance,” Jain told IANS.

“There is increase in resistance to antibiotics including clarithromycin which is undoubtedly a worrisome situation in the country,” Jain said.

However, Deepak Verma of Internal Medicine at Columbia Asia Hospital, Ghaziabad said: “Most of the cases that we see in India are connected to gram-negative bacteria such as e.coli that causes urinary tract infection (UTI).”

He added that the main causes for antibiotic resistance in India are its rampant misuse where people indulge in self-doctoring as well as taking medicines prescribed by unregistered medical practitioners, including quacks who suggest antibiotics quite indiscriminately.

Antibiotics
According to the World Health Organization (WHO), resistance to Antibiotics is one of the biggest threats to global health, food security and development today. Wikimedia Commons

“They primarily use antibiotics symptomatically which is not a correct method for all ailments — without blood and urine culture. Antibiotics can force the pathogen to develop resistance,” Verma explained.

ALSO READ: Researchers Develop a New Vaccine to Stop Bovine TB

“Since the clinical culture in India is different from that of the western countries, the lack of awareness of the right process to prescribe antibiotics increases the chances of people using antibiotics without questioning,” he stressed. (IANS)