Sunday November 17, 2019

New Treatment Against Peanut Allergy

Compared to the placebo group, participants who took AR101 had less severe allergy symptoms

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New treatment shows promise against peanut allergy. Pixabay

n a first, an oral immunotherapy drug derived from peanut protein could help build tolerance and eliminate potentially deadly reactions in children and adolescents with severe peanut allergies.

The study showed that controlled ingestion of the medication, called AR101, derived from peanut protein, could build tolerance as well as reduce severe allergy symptoms.

“Almost 6 million American children are currently living with a life-threatening food allergy,” said Christina Ciaccio, Associate Professor from the University of Chicago in the US.

“Every three minutes a food allergy reaction sends someone to the emergency room, contributing to the total annual cost of caring for children with food allergy to nearly $25 billion. Despite this, not a single treatment for food allergy has been approved by the FDA,” she said.

However, the drug “is not a quick fix, and it doesn’t mean people with peanut allergy will be able to eat peanuts whenever they want”, the researchers stressed, in the paper published in the New England Journal of Medicine.

But it is definitely a breakthrough and “results of this landmark trial are likely to lead to the first FDA-approved treatment for food allergy in 2019”, Ciaccio said.

The study showed that controlled ingestion of the medication, called AR101, derived from peanut protein, could build tolerance as well as reduce severe allergy symptoms.

As a result, people who receive and are able to tolerate this treatment should be protected from accidental exposures, the researchers noted, adding that once someone stops the treatment, there is no longer a protective effect.

For the study, the researchers at the American College of Allergy, Asthma and Immunology (ACAAI) in the US included 496 participants aged from four to 55 years, most were four to 17 year olds, and all had peanut allergy.

One third of the participants were given a placebo, while the remaining two-thirds were given peanut protein powder as part of an oral food challenge (OFC) in increasing amounts until reaching the “maintenance dose” — equivalent of one peanut daily.

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Compared to the placebo group, participants who took AR101 had less severe allergy symptoms.

Furthermore, two-thirds of the people were able to tolerate the equivalent of two peanuts per day after nine to 12 months of treatment, and half the patients tolerated the equivalent of four peanuts. (IANS)

Next Story

Heavier Babies are More Prone to Childhood Allergies: Research

For the study, published in the Journal of Allergy and Clinical Immunology, the research team carried out a systematic review assessing past studies in humans

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For each kilogram increase in birth weight of Babies, there was a 44 per cent increase in the risk that a child had food allergies or a 17 per cent increase in the risk that they had eczema. Pixabay

Parents, take note. Researchers have found that heavier babies are more likely to suffer childhood food allergies or eczema.

For the study, published in the Journal of Allergy and Clinical Immunology, the research team carried out a systematic review assessing past studies in humans.

After screening more than 15,000 studies, they identified 42 that included data on more than two million allergy sufferers.

“We analysed the associations between birth weight, corrected for gestational age, and the incidence of allergic diseases in children and adults,” said Kathy Gatford from the University of Adelaide in Australia.

“For each kilogram increase in birth weight there was a 44 per cent increase in the risk that a child had food allergies or a 17 per cent increase in the risk that they had eczema,” Gatford said.

According to the researchers, they analysed studies that included over 2.1 million people affected by allergic dermatitis, commonly known as eczema, nearly 70,000 people affected by food allergies and over 100,000 people with allergic rhinitis or hay fever.

Most of the studies were in children from developed countries and most were European.

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Study Says that heavier Babies are more likely to suffer childhood food allergies or eczema. Pixabay

“Allergic diseases including eczema, hay fever, food allergies, anaphylaxis and asthma are estimated to affect 30-40 per cent of the world’s population,” Gatford said..

“It is increasingly clear that genetics alone do not explain risks of developing allergies, and that environmental exposures before and around birth can programme individuals to increased or decreased risk of allergies,” Gatford added.

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Most of the allergies in these studies were assessed in young children. (IANS)