Friday June 21, 2019

Next big step in the medicine world: Mini human heart developed in a lab by an Indian -origin scientist



By Newsgram Staff Writers

Human heart has been replicated under laboratory environment by Anurag Mathur, an Indian-origin scientist with the University of California at Berkeley. This will help researchers predict if a certain kind of medicine will adversely affect the human body or how much dosage of a drug is required.

“Many times doctors and researchers fail to predict a response to a certain drug or medicine because of the inaccuracy of the models used, like mice, that don’t have the same reactions as human tissue.” Mathur was quoted by Xinhua.

The mini-heart is created with human-induced Pluripotent stem cells that can form many different types of tissues. A special silicon microchip in the mini heart makes these tissues mimic blood vessels.

The researchers are calling this the next big step in the medicine world. With this kind of development medicine can become completely personalized. The doctors will just require a sample from the patient and he/she will be able to have his or her heart modeled in a lab with all the tests done.

“Doctors will be able to predict how certain drugs react on specific patients, thus preventing many illnesses and loss of valuable time,” a hopeful Anurag Mathur said.

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Less Than 7 Hours of Sleep Bad for Your Heart, Warn Researchers

The results suggest that microRNAs in blood could be used as a marker of cardiovascular disease in people with insufficient sleep

Soothing colours, right scent aid sound sleep. Pixabay

People who sleep less than seven hours each night are at higher risk of developing cardiovascular disease (CVD) and coronary heart disease, warn researchers.

The findings, published in the journal Experimental Physiology, show that people who sleep fewer than seven hours per night have lower blood levels of three physiological regulators, or microRNAs, which influence gene expression and play a key role in maintaining vascular health.

“This study proposes a new potential mechanism through which sleep influences heart health and overall physiology,” said Christopher DeSouza, Professor at University of Colorado in the US.

For the study, the research team took blood samples from a small group of healthy men and women, age 44 to 62, who had filled out questionnaires about their sleep habits.

While half of the participants slept seven to 8.5 hours nightly, the other half slept five to 6.8 hours every night.

Less than 7 hours of sleep linked to hardened arteries. Pixabay

The research team measured the expression of nine microRNAs previously associated with inflammation, immune function or vascular health.

They found that people with insufficient sleep had 40 to 60 per cent lower circulating levels of miR-125A, miR-126, and miR-146a than those who slept enough.

“Why seven or eight hours seems to be the magic number is unclear. However, it is plausible that people need at least seven hours of sleep per night to maintain levels of important physiological regulators, such as microRNAs,” DeSouza added.

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“They are like cellular brakes, so if beneficial microRNAs are lacking that can have a big impact on the health of the cell,” DeSouza said.

The results suggest that microRNAs in blood could be used as a marker of cardiovascular disease in people with insufficient sleep. (IANS)