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Nine new osteoarthritis genes discovered

The team looked for genes that were active in the progression of the disease by extracting the relevant cells from healthy and diseased tissue

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Osteoporosis
Bone loss in adults. IANS
  • Researchers have discovered nine new genes responsible for osteoarthritis
  • These can help in developing new therapies
  • This research may also help in reducing the risk of the disease

Researchers have discovered nine novel genes for osteoarthritis that may open the door to new targeted therapies for this debilitating disease in the future.

Of the nine genes associated with osteoarthritis, researchers identified five genes in particular that differed significantly in their expression in healthy and diseased tissue.

These genes can help create new therapies. blogs.discovermagazine.com

The five genes present novel targets for future research into therapies, the researcher said. According to the researchers, there is no treatment for osteoarthritis. The disease is managed with pain relief and culminates in joint replacement surgery, which has variable outcomes.

“These results are an important step towards understanding the genetic causes of osteoarthritis and take us closer to uncovering the mechanism behind the disease,” said co-author of the study, Eleni Zengini from the University of Sheffield.

For the study, published in the journal Nature Genetics, researchers investigated the genetics behind osteoarthritis, as well as the diseases and traits that are linked to it.

The team studied 16.5 million DNA variations. Following combined analysis in up to 30,727 people with osteoarthritis and nearly 300,000 people without osteoarthritis in total — the controls –, scientists discovered nine new genes that were associated with osteoarthritis.

This may also help in finding ways to reduce the risk of the disease.

The researchers then investigated the role of the nine new genes in osteoarthritis, by studying both normal cartilage and diseased cartilage from individuals who had a joint replacement.

The team looked for genes that were active in the progression of the disease by extracting the relevant cells from healthy and diseased tissue, studying the levels of proteins in the tissue and sequencing the RNA — the messenger that carries instructions from DNA for controlling the production of proteins. IANS

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Novel Device by Microsoft Can Store Digital Info as DNA

Further, the team also developed techniques to search for and retrieve only images that contain an apple or a green bicycle — using the molecules themselves and without having to convert the files back into a digital format

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Microsoft, Taiwan AI
A man walks past a Microsoft sign set up for the Microsoft BUILD conference at Moscone Center in San Francisco, April 28, 2015. VOA

Tech major Microsoft has successfully developed an end-to-end automated DNA storage device that can translate digital information into DNA and back to bits, the company said in a blog post.

The fully automated system to store and retrieve data in manufactured DNA is a key step in moving the technology out of the research lab and into commercial datacenters.

The novel system, developed in partnership with University of Washington, translated “HELLO” into DNA and converted it back to digital data in just 21 hours, reported the paper published in Nature Scientific Reports journal.

“Our ultimate goal is to put a system into production that, to the end user, looks very much like any other cloud storage service — bits are sent to a datacenter and stored there and then they just appear when the customer wants them,” Karin Strauss, principal researcher at Microsoft, wrote in the post on Thursday.

“To do that, we needed to prove that this is practical from an automation perspective,” Strauss added.

The system has so far stored one gigabyte of data in DNA, which includes cat photographs, great literary works, pop videos as well as archival recordings in DNA, which could be retrieved without errors, the researchers said.

microsoft
FILE – Microsoft Corp. signage is seen outside the Microsoft Visitor Center in Redmond, Washington, July 3, 2014. VOA

The automated DNA data storage system uses software that converts the ones and zeros of digital data into the As, Ts, Cs and Gs that make up the building blocks of DNA.

Then it uses cheap lab equipments to flow the necessary liquids and chemicals into a synthesiser that builds manufactured snippets of DNA and to push them into a storage vessel.

When the system needs to retrieve the information, it adds other chemicals to properly prepare the DNA and uses microfluidic pumps to push the liquids into other parts of the system that “read” the DNA sequences and convert it back to information that a computer can understand.

Also Read- Top Priorities of Tesla CEO Include Car Deliveries

Information is stored in synthetic DNA molecules created in a lab, not DNA from humans or other living things, and can be encrypted before it is sent to the system.

Further, the team also developed techniques to search for and retrieve only images that contain an apple or a green bicycle — using the molecules themselves and without having to convert the files back into a digital format.

“We are definitely seeing a new kind of computer system being born here where you are using molecules to store data and electronics for control and processing. Putting them together holds some really interesting possibilities for the future,” said Luis Ceze, Professor at the varsity. (IANS)