Thursday September 20, 2018
Home Lead Story Nine new oste...

Nine new osteoarthritis genes discovered

The team looked for genes that were active in the progression of the disease by extracting the relevant cells from healthy and diseased tissue

0
//
34
Osteoporosis
Bone loss in adults. IANS
Republish
Reprint
  • Researchers have discovered nine new genes responsible for osteoarthritis
  • These can help in developing new therapies
  • This research may also help in reducing the risk of the disease

Researchers have discovered nine novel genes for osteoarthritis that may open the door to new targeted therapies for this debilitating disease in the future.

Of the nine genes associated with osteoarthritis, researchers identified five genes in particular that differed significantly in their expression in healthy and diseased tissue.

These genes can help create new therapies. blogs.discovermagazine.com

The five genes present novel targets for future research into therapies, the researcher said. According to the researchers, there is no treatment for osteoarthritis. The disease is managed with pain relief and culminates in joint replacement surgery, which has variable outcomes.

“These results are an important step towards understanding the genetic causes of osteoarthritis and take us closer to uncovering the mechanism behind the disease,” said co-author of the study, Eleni Zengini from the University of Sheffield.

For the study, published in the journal Nature Genetics, researchers investigated the genetics behind osteoarthritis, as well as the diseases and traits that are linked to it.

The team studied 16.5 million DNA variations. Following combined analysis in up to 30,727 people with osteoarthritis and nearly 300,000 people without osteoarthritis in total — the controls –, scientists discovered nine new genes that were associated with osteoarthritis.

This may also help in finding ways to reduce the risk of the disease.

The researchers then investigated the role of the nine new genes in osteoarthritis, by studying both normal cartilage and diseased cartilage from individuals who had a joint replacement.

The team looked for genes that were active in the progression of the disease by extracting the relevant cells from healthy and diseased tissue, studying the levels of proteins in the tissue and sequencing the RNA — the messenger that carries instructions from DNA for controlling the production of proteins. IANS

Click here for reuse options!
Copyright 2018 NewsGram

Next Story

More Than 1000 Gene Variants Linked to Educational Attainment Identified

However, the total influence of the genetic variants is small, explaining about four per cent of the variation in educational attainment across individuals, the scientists said

0
Education
The team analysed a combined 71 datasets comprising over 1.1 million participants with European ancestry from 15 different countries and who were least 30 years old. Pixabay

An international team of scientists has identified nearly 1,300 genetic variants associated with how much education someone may complete.

Educational attainment is primarily influenced by environmental and social factors, but it is also influenced by genes associated with, for example, cognitive function such as memory and personality traits such as conscientiousness.

“We found that many of the genes associated with educational attainment are influential in virtually all stages of brain development and in neural communication within the brain,” said Peter Visscher, Professor at the University of Queensland in Australia.

Genetic variants on the X chromosome explain virtually identical amounts of variation in men and women.

This finding, published in the journal Nature Genetics, lends support to the hypothesis that there are no genetically based sex differences in the amount of variation in educational attainment.

genes
Genetic variants on the X chromosome explain virtually identical amounts of variation in men and women. Pixabay

However, the total influence of the genetic variants is small, explaining about four per cent of the variation in educational attainment across individuals, the scientists said.

“Even variants with the largest effects predict, on average, only about three more weeks of schooling in those who have those variants compared to those who don’t,” said Daniel Benjamin, Associate Professor at University of Southern California (USC)- Dornsife.

“Yet, when we analyze the combined effects of many genetic variants, taken together they can predict the length of a person’s formal education as well as demographic factors,” he added.

Also Read: New Link Found Between Alcohol, Genes And Heart Failure

While the new number is far more than the 74 variants initially discovered in a smaller study two years ago, there are many other genetic variants associated with educational attainment that have not yet been identified, the researchers said.

For the study, the team analysed a combined 71 datasets comprising over 1.1 million participants with European ancestry from 15 different countries and who were least 30 years old. (IANS)