Tuesday September 25, 2018

Novel stroke treatment repairs damaged brain tissue

Researchers have developed a new stem-cell based treatment for stroke that reduces brain damage and accelerates the brain's natural healing tendencies

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The new research can reduce the threat of permanent brain damage considerably.
The new research can reduce the threat of permanent brain damage considerably. Wikimedia Commons
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Researchers have developed a new stem-cell based treatment for stroke that reduces brain damage and accelerates the brain’s natural healing tendencies.

The treatment called AB126 was developed using extracellular vesicles (EV) — fluid-filled structures known as exosomes — which are generated from human neural stem cells.

“This is truly exciting evidence because exosomes provide a stealth-like characteristic, invisible even to the body’s own defences.

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When packaged with therapeutics, these treatments can actually change cell progression and improve functional recovery,” said Steven Stice, a professor at the University of Georgia in the US who led the research team.

Fully able to cloak itself within the bloodstream, this type of regenerative EV therapy appears to be the most promising in overcoming the limitations of many cells therapies-with the ability for exosomes to carry and deliver multiple doses-as well as the ability to store and administer treatment, the researchers said.

Human clinical trials for the treatment could begin as early as next year, the researchers added.
Human clinical trials for the treatment could begin as early as next year, the researchers added. Wikimedia Commons

Small in size, the tiny tubular shape of an exosome allows EV therapy to cross barriers that cells cannot be said the study published in the journal Translational Stroke Research.

Following the administration of AB126, the researchers used MRI scans to measure brain atrophy rates in preclinical, age-matched stroke models, which showed an approximately 35 percent decrease in the size of injury and 50 percent reduction in brain tissue loss.

Also Read: Father’s Stress Linked To Kids’ Brain Development

“Until now, we had very little evidence specific to neural exosome treatment and the ability to improve motor function. Just days after stroke, we saw better mobility, improved balance and measurable behavioural benefits in treated animal models,” Stice said.

Human clinical trials for the treatment could begin as early as next year, the researchers added. (IANS)

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Researchers Develop Novel Device to Improve Diagnosis of Dizziness

In this technology, detailed in the journal Medical Devices: Evidence and Research, the sound levels which patients are exposed to can be minimised

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Dizziness
Novel device to improve diagnosis of dizziness.

Researchers have developed a new vibrating device using bone conduction technology, that can identify the causes of dizziness.

Half of older adults over 65 years suffer from dizziness and problems with balance. However, the current tests to identify the causes of such problems are painful and can risk hearing damage.

The novel type of vibrating device, developed by researchers from the Chalmers University of Technology in Sweden, is placed behind the ear of the patient during the test.

According to Bo Hakansson, Professor at Chalmers, the vibrating device is small and compact in size, and optimised to provide an adequate sound level for triggering the reflex at frequencies as low as 250 hertz (Hz).

But in bone conduction transmission, sound waves are transformed into vibrations through the skull, stimulating the cochlea within the ear, in the same way as when sound waves normally go through the ear canal, the eardrum and the middle ear.

Dizziness
Dizziness. Pixabay

In this technology, detailed in the journal Medical Devices: Evidence and Research, the sound levels which patients are exposed to can be minimised.

“The new vibrating device provides a maximum sound level of 75 decibels. The test can be performed at 40 decibels lower than today’s method using air conducted sounds through headphones,” said Karl-Johan Freden Jansson, postdoctoral researcher at Chalmers.

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“This eliminates any risk that the test itself could cause hearing damage,” Jansson added.

The benefits also include safer testing for children, and that patients with impaired hearing function due to chronic ear infections or congenital malformations in the ear canal and middle ear can be diagnosed for the origin of their dizziness, the researchers said. (IANS)