Wednesday March 20, 2019

Novel stroke treatment repairs damaged brain tissue

Researchers have developed a new stem-cell based treatment for stroke that reduces brain damage and accelerates the brain's natural healing tendencies

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The new research can reduce the threat of permanent brain damage considerably.
The new research can reduce the threat of permanent brain damage considerably. Wikimedia Commons

Researchers have developed a new stem-cell based treatment for stroke that reduces brain damage and accelerates the brain’s natural healing tendencies.

The treatment called AB126 was developed using extracellular vesicles (EV) — fluid-filled structures known as exosomes — which are generated from human neural stem cells.

“This is truly exciting evidence because exosomes provide a stealth-like characteristic, invisible even to the body’s own defences.

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When packaged with therapeutics, these treatments can actually change cell progression and improve functional recovery,” said Steven Stice, a professor at the University of Georgia in the US who led the research team.

Fully able to cloak itself within the bloodstream, this type of regenerative EV therapy appears to be the most promising in overcoming the limitations of many cells therapies-with the ability for exosomes to carry and deliver multiple doses-as well as the ability to store and administer treatment, the researchers said.

Human clinical trials for the treatment could begin as early as next year, the researchers added.
Human clinical trials for the treatment could begin as early as next year, the researchers added. Wikimedia Commons

Small in size, the tiny tubular shape of an exosome allows EV therapy to cross barriers that cells cannot be said the study published in the journal Translational Stroke Research.

Following the administration of AB126, the researchers used MRI scans to measure brain atrophy rates in preclinical, age-matched stroke models, which showed an approximately 35 percent decrease in the size of injury and 50 percent reduction in brain tissue loss.

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“Until now, we had very little evidence specific to neural exosome treatment and the ability to improve motor function. Just days after stroke, we saw better mobility, improved balance and measurable behavioural benefits in treated animal models,” Stice said.

Human clinical trials for the treatment could begin as early as next year, the researchers added. (IANS)

Next Story

Intake Of Vitamin B Nutrient Can Prevent Babies From Brain Disorders Caused By Cold During Pregnancy

Cold and flu are often unavoidable, even if the mother has had a flu shot. But cold and flu during pregnancy double the risk of future mental illnesses.

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When mothers had a cold or flu during the first 16 weeks of pregnancy, the newborns'  ability to cease or delay the effect on the brain decreased by 27 per cent. Pixabay

Besides flu vaccines, maternal intake of a vitamin B nutrient can prevent babies from brain disorders caused by cold or flu in pregnancy, say researchers.

The study showed that higher levels of choline prevented brain problems and mental illness, like attention deficit disorder and schizophrenia, in babies even when the mother had cold or flu during pregnancy.

“Cold and flu are often unavoidable, even if the mother has had a flu shot. But cold and flu during pregnancy double the risk of future mental illnesses. More and more information show choline helps the baby’s brain develop properly,” said Robert Freedman, Professor at the University of Colorado in the US.

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The study showed that higher levels of choline prevented brain problems and mental illness, like attention deficit disorder and schizophrenia, in babies even when the mother had cold or flu during pregnancy. Pixabay

“We found higher levels of choline prevent foetal brain problems from developing, even when the mother is infected. Choline supplements in pregnancy can have a lifelong benefit for the infant,” Freedman said.

For the study, published in the Journal of Paediatrics, the team assessed prenatal maternal infection, C-Reactive Protein (CRP) — a marker of maternal inflammation — and the mothers’ choline levels.

Brain development before birth was assessed by measuring the baby’s brain waves soon after birth.

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Choline supplements in pregnancy can have a lifelong benefit for the infant,” Freedman said.
Pixabay

When mothers had a cold or flu during the first 16 weeks of pregnancy, the newborns’
ability to cease or delay the effect on the brain decreased by 27 per cent.

Maternal flu also decreased children’s ability to pay attention and play.

Also Read: Study Warns Patients That Now Drugs Contain Inactive Ingredient

However, these effects were prevented if the mother had higher choline levels, the findings showed.

While the body creates some choline on its own and it is also naturally present in certain foods, including liver, red meat and eggs, pregnant women are recommended 450 mg of choline a day to improve babies’ brain development. (IANS)