Tuesday October 23, 2018

Obesity affects males more than females: Study

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fat man holding a measurement tape

By NewsGram Staff Writer

Obesity may be tougher on male immune systems than females, suggests a study led by an Indian-American researcher.

Kanakadurga Singer, assistant professor in pediatrics at the University of Michigan, found that high-fat diets reprogram blood stem cells in male mice, promoting metabolic disease.

“Men and women have very different cardiovascular and diabetes risk. Male mice are often studied because their risk for developing these diseases is higher,” Singer explained.

For this, researchers compared how mice from each sex reacted to high-fat diets.

They found that in young reproductive-age female mice who were fed a high-fat diet which made them obese, the body produced only a mild inflammatory white blood cell response.

In male mice, however, diet-induced obesity made more active inflammatory white blood cells and enhanced their progenitors.

This, in turn, made the male mice more prone to higher blood glucose and insulin levels.

“We found that obesity did not trigger inflammation in female mice the way it did in males,” Singer added.

The research helps in providing the foundation for future clinical studies exploring how these differences impact diseases such as diabetes.

“Our research highlights the need to broaden clinical investigations and animal studies to include both males and females to better guide new interventions,” Singer said.

The study was published in the Journal of Biological Chemistry.

(With inputs from IANS)

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Exposure to Certain Disinfectants Can Cause Obesity in Kids: Research

The use of eco-friendly products may be linked to healthier overall maternal lifestyles and eating habits.

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Disinfectants
How common household cleaners could make kids overweight. Flickr

Early life exposure to certain disinfectants used at home could be making children overweight by altering the composition of their gut bacteria, suggests new research.

Babies living in households that used eco-friendly cleaners had different microbiota and were less likely to be overweight as toddlers, showed the findings published in CMAJ (Canadian Medical Association Journal).

For the study, the researchers analysed the gut flora of 757 infants from the general population at age 3-4 months and weight at ages 1 and 3 years, looking at exposure to disinfectants, detergents and eco-friendly products used in the home.

Disinfectants
Mother’s Lifestyle Choices Linked to Obesity Risk in Adolescents. Pixabay

The researchers looked at data from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort on microbes in infant fecal matter. They used World Health Organization growth charts for body mass index (BMI) scores.

Associations with altered gut flora in babies 3-4 months old were strongest for frequent use of household disinfectants such as multi-surface cleaners, which showed lower levels of Haemophilus and Clostridium bacteria but higher levels of Lachnospiraceae.

The researchers also observed an increase in Lachnospiraceae bacteria with more frequent cleaning with disinfectants.

They, however, did not find the same association with detergents or eco-friendly cleaners.

“We found that infants living in households with disinfectants being used at least weekly were twice as likely to have higher levels of the gut microbes Lachnospiraceae at age 3-4 months,” said Anita Kozyrskyj, Professor at the University of Alberta in Canada.

Disinfectants
The researchers looked at data from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort on microbes in infant fecal matter. Flcikr

“When they were 3 years old, their body mass index was higher than children not exposed to heavy home use of disinfectants as an infant,” Kozyrskyj said.

“Those infants growing up in households with heavy use of eco cleaners had much lower levels of the gut microbes Enterobacteriaceae,” she said.

Also Read: Asthma Ups The Chance of Obesity: Study

Kozyrskyj suggests that the use of eco-friendly products may be linked to healthier overall maternal lifestyles and eating habits, contributing in turn to the healthier gut microbiomes and weight of their infants. (IANS)