Friday October 18, 2019

Obesity affects males more than females: Study

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fat man holding a measurement tape

By NewsGram Staff Writer

Obesity may be tougher on male immune systems than females, suggests a study led by an Indian-American researcher.

Kanakadurga Singer, assistant professor in pediatrics at the University of Michigan, found that high-fat diets reprogram blood stem cells in male mice, promoting metabolic disease.

“Men and women have very different cardiovascular and diabetes risk. Male mice are often studied because their risk for developing these diseases is higher,” Singer explained.

For this, researchers compared how mice from each sex reacted to high-fat diets.

They found that in young reproductive-age female mice who were fed a high-fat diet which made them obese, the body produced only a mild inflammatory white blood cell response.

In male mice, however, diet-induced obesity made more active inflammatory white blood cells and enhanced their progenitors.

This, in turn, made the male mice more prone to higher blood glucose and insulin levels.

“We found that obesity did not trigger inflammation in female mice the way it did in males,” Singer added.

The research helps in providing the foundation for future clinical studies exploring how these differences impact diseases such as diabetes.

“Our research highlights the need to broaden clinical investigations and animal studies to include both males and females to better guide new interventions,” Singer said.

The study was published in the Journal of Biological Chemistry.

(With inputs from IANS)

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Certain Flavoured E-Cigarettes Worsen Severity of Diseases Such as Asthma

This is especially important for those with respiratory disease, whom are vulnerable to the effects of smoking

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Flavoured, E-Cigarettes, Diseases
Certain flavoured e-cigarettes, even without nicotine, may change how airways, affected by an allergic disease, function, thus worsening the severity of diseases such as asthma, say researchers. Pixabay

Certain flavoured e-cigarettes, even without nicotine, may change how airways, affected by an allergic disease, function, thus worsening the severity of diseases such as asthma, say researchers.

For the first time, a model of asthma was used to investigate the effect of a range of popular e-cigarette flavours, with and without nicotine.

“This is especially important for those with respiratory disease, whom are vulnerable to the effects of smoking,” Dr Chapman said.

“The majority of e-cigarette smokers use flavoured liquids but there is some evidence that flavour additives can be toxic when inhaled,” said Dr David Chapman from from the University of Technology Sydney (UTS).

Flavoured, E-Cigarettes, Diseases
Certain flavoured e-cigarettes, even without nicotine, may change how airways, affected by an allergic disease, function, thus worsening the severity of diseases such as asthma, say researchers. Pixabay

The use of e-cigarettes has dramatically increased in the past few years, especially among younger smokers globally.

Despite the suggestion they are a healthier alternative to tobacco cigarettes, there is a lack of evidence in both animal studies and human data on the effect of e-cigarettes on lung function.

The researchers found that some flavoured e-cigarettes, even in the absence of nicotine, can worsen disease severity.

“The exact effects on features of asthma were dependent upon the specific flavour, suggesting not all flavoured e-cigarettes will have the same consequences on lung health,” Dr Chapman said in the study published in Scientific Reports.

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In this study, the flavour Black Licorice exaggerated airway inflammation whereas Cinnacide had the opposite effect, suppressing airway inflammation.

The researchers didn’t analyse the liquids directly, to confirm what they contained, however there is evidence from previous research that flavours categorised as “buttery/creamy” and “cinnamon”, which likely include “Banana Pudding” and “Cinnacide”, respectively, are toxic.

Caution should be taken in promoting the use of flavoured e-cigarettes to patients with respiratory disease such as asthma and that policy makers should consider restricting the use of flavoured e-cigarettes, the team added. (IANS)