Thursday June 27, 2019

Obesity affects males more than females: Study

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fat man holding a measurement tape

By NewsGram Staff Writer

Obesity may be tougher on male immune systems than females, suggests a study led by an Indian-American researcher.

Kanakadurga Singer, assistant professor in pediatrics at the University of Michigan, found that high-fat diets reprogram blood stem cells in male mice, promoting metabolic disease.

“Men and women have very different cardiovascular and diabetes risk. Male mice are often studied because their risk for developing these diseases is higher,” Singer explained.

For this, researchers compared how mice from each sex reacted to high-fat diets.

They found that in young reproductive-age female mice who were fed a high-fat diet which made them obese, the body produced only a mild inflammatory white blood cell response.

In male mice, however, diet-induced obesity made more active inflammatory white blood cells and enhanced their progenitors.

This, in turn, made the male mice more prone to higher blood glucose and insulin levels.

“We found that obesity did not trigger inflammation in female mice the way it did in males,” Singer added.

The research helps in providing the foundation for future clinical studies exploring how these differences impact diseases such as diabetes.

“Our research highlights the need to broaden clinical investigations and animal studies to include both males and females to better guide new interventions,” Singer said.

The study was published in the Journal of Biological Chemistry.

(With inputs from IANS)

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Having a Cup of Coffee Can Help You Fight Obesity, Diabetes

“The results were positive and we now need to ascertain that caffeine as one of the ingredients in the coffee is acting as the stimulus or if there’s another component helping with the activation of brown fat. We are currently looking at caffeine supplements to test whether the effect is similar,” Symonds added

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coffee
A patron holds an iced beverage at a Starbucks coffee store in Pasadena, Calif., July 25, 2013. VOA

Drinking a cup of coffee can be helpful in fighting obesity and diabetes as it stimulates body’s fat-fighting defences, says a new study.

The study, published in Scientific Reports journal, found components which could have a direct effect on “brown fat” functions, an important part of the human body which plays a key role in how quickly we can burn calories as energy.A

Brown adipose tissue (BAT), also known as brown fat, is one of two types of fat found in humans and other mammals. Its main function is to generate body heat by burning calories (opposed to white fat, which is a result of storing excess calories).

People with a lower body mass index (BMI) therefore have a higher amount of brown fat.

“Brown fat works in a different way to other fat in your body and produces heat by burning sugar and fat, often in response to cold. Increasing its activity improves blood sugar control as well as improving blood lipid levels and the extra calories burnt help with weight loss,” said study’s co-director Michael Symonds, Professor at the University of Nottingham.. A

“This is the first study in humans to show that something like a cup of coffee can have a direct effect on our brown fat functions. The potential implications of our results are pretty big, as obesity is a major health concern for society and we also have a growing diabetes epidemic and brown fat could potentially be part of the solution in tackling them,” he noted.

A barista pours steamed milk into a cup of coffee at a cafe in Los Angeles, Sept. 22, 2017. State health officials proposed a regulation change Friday that would declare coffee doesn't present a significant cancer risk, countering a California court ruling.
A barista pours steamed milk into a cup of coffee at a cafe in Los Angeles, Sept. 22, 2017. VOA

For the study, the researcehes started with a series of stem cell studies to see if caffeine would stimulate brown fat. After finding the right dose, they then moved on to humans to see if the results were similar.

They used a thermal imaging technique to trace the body’s brown fat reserves. The non-invasive technique helps the team to locate brown fat and assess its capacity to produce heat.

“From our previous work, we knew that brown fat is mainly located in the neck region, so we were able to image someone straight after they had a drink to see if the brown fat got hotter,” he said.

Also Read: Poor Sleep Quality Associated with Reduced Memory in Senior Citizens

“The results were positive and we now need to ascertain that caffeine as one of the ingredients in the coffee is acting as the stimulus or if there’s another component helping with the activation of brown fat. We are currently looking at caffeine supplements to test whether the effect is similar,” Symonds added.

“Once we have confirmed which component is responsible for this, it could potentially be used as part of a weight management regime or as part of glucose regulation programme to help prevent diabetes,” he concluded. (IANS)