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Pakistan rescues Kidnapped Chinese tourist

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Islamabad: A Chinese tourist who was kidnapped in northwestern Pakistan a year ago has been rescued, authorities said on Sunday. Pakistani Interior Minister Chaudhry Nisar Ali Khan said Pakistani security forces and intelligence agencies were involved in the rescue operation. However, he did not mention where and when the tourist was rescued, Duniya News reported.
The Chinese tourist, named Hong Xudong and from central China’s Hubei Province, would be handed over to the Chinese Embassy in Pakistan, according to Nisar. Hong was abducted in Pakistan’s Dera Ismail Khan district on May 19, 2014 when travelling in the country on his bicycle.

He entered Pakistan in April from India and was on his way to Iran. The Pakistani Taliban claimed responsibility for the kidnapping. There were also unverified reports and a video earlier this year showing that Hong was in the custody of the Taliban.

(IANS)

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Chinese Scientists Develop Combined Tumor-Killing Therapy

The Chinese Academy of Sciences and Fudan University developed a common immune checkpoint inhibitor in a nanoparticle formulation

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Chinese, Scientists, Tumor
The study published on Friday in the journal Science Immunology described the new cancer immunotherapy that can prevent the immune system from becoming tolerant of tumors. Pixabay

Chinese scientists developed a combined tumor-killing therapy that can be activated specifically at tumor sites in mouse models of cancer, which is more effective than previous similar therapies.

The study published on Friday in the journal Science Immunology described the new cancer immunotherapy that can prevent the immune system from becoming tolerant of tumors, which occurs in 30 per cent of all cancer patients, the Xinhua news agency reported.

A team led by Wang Dangge from Shanghai Institute of Materia Medica under the Chinese Academy of Sciences and Fudan University developed a common immune checkpoint inhibitor in a nanoparticle formulation, which is highly tumor-specific.

The checkpoint inhibitor is a kind of increasingly popular anti-tumor drug. It can block proteins that keep immune T cells from killing cancer. But the checkpoint inhibitor used to target those immune system-suppressing proteins like PD-1 and PD-L1 often fails to reach deep-seated or metastatic tumors.

Chinese, Scientists, Tumor
Chinese scientists developed a combined tumor-killing therapy that can be activated specifically at tumor sites in mouse models of cancer, Pixabay

Wang’s team combined the nanoparticles carrying PD-L1-targeting antibodies with a light-activated molecule. The molecule called photosensitiser can produce tumor-killing reactive oxygen species after encountering a protein abundant in tumors, according to the study.

In mouse models, a local near-infrared radiation that activated the photosensitiser, along with the administration of antibodies-carrying nanoparticles, promoted the infiltration of cancer cell-killing T cells into the tumor site and made the tumors more sensitive to the checkpoint blockade.

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This combination also helped the nanoparticles effectively suppress tumor growth and metastasis to the lung and lymph nodes, resulting in approximately 80 per cent mouse survival over 70 days, compared to complete mouse death in 45 days in the group treated with only PD-L1 antibodies, according to the study. (IANS)