Sunday August 19, 2018

Premature birth can be controlled by a Diabetes drug

The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation.

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Diabetes drug can help in blocking premature births. Image Source: daily-sun.com
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  • The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation
  • The mice treated with metformin went on to have full term births, the findings showed
  • Metformin appears to be a potentially safer alternative that works along the same molecular pathway, Dey said

A drug used by millions of people as the frontline treatment for Type-2 diabetes, may also play an unexpected role in blocking a significant cause of preterm birth, say researchers including one of Indian-origin.

“This proof-of-concept study illuminates a potential mechanism behind preterm birth,” said senior author of the study Sudhansu K. Dey, Director of the Division of Reproductive Sciences at Cincinnati Children’s Hospital Medical Center in Ohio, US.

Premature baby. Image Source: www.todaysparent.com
Premature baby. Image Source: www.todaysparent.com

“It also demonstrates possible remedies that are already approved for human use,” Dey noted. The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation.

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The study is important for two reasons, according to the researchers. First, it details a little understood molecular pathway that can lead to premature birth by disrupting the function of the decidua – a thick membrane that lines the uterus and supports the continued growth of developing foetuses.

Mice treated with Metformin. Image Source: www.medpagetoday.com
Mice treated with Metformin. Image Source: www.medpagetoday.com

Second, the researchers demonstrated – in mice — two successful methods for restoring the lining’s function and achieving healthy, full term births. The study involved analysing mice bred to have a condition known to make pregnancies more likely to end in premature birth.

The mice treated with metformin went on to have full term births, the findings showed.

The team also reported similar – but less effective – results when treating mice with resveratrol, an anti-oxidant and anti-aging dietary supplement made from grape seed extract.

Sudhansu K. Dey, Director of the Division of Reproductive Sciences. Image Source: www.cincinnatichildrens.org
Sudhansu K. Dey, Director of the Division of Reproductive Sciences. Image Source: www.cincinnatichildrens.org

In previous studies, Dey and colleagues discovered that rapamycin, an immune suppressing agent, showed promise in mice at preventing preterm birth. However, that medication may be risky for use in pregnant women.

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Metformin appears to be a potentially safer alternative that works along the same molecular pathway, Dey said. Preterm birth can be caused by many factors. It remains unclear how many preterm births are triggered by early decidual ageing, but Dey said it could be a significant number.

Metformin. Image Source: www.canadianpharmacy365.net
Metformin. Image Source: www.canadianpharmacy365.net

The process of preparing and conducting human clinical trials to further test the medications could take several years. (IANS)

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  • Rhonda

    In June of 2015, it was discovered that I had type 2 diabetes, By the end of the month, I was given a prescription for Metformin, I stated the ADA diet and followed it completely for several weeks but was unable to get my blood sugar below 140, With no results to how for my hard work, I panicked and called my doctor,His response? Deal with it. I began to feel that something wasn’t right and do my own research. Then I found Rachel’s blog (google ” HOW I FREED MYSELF FROM THE DIABETES ” ) ,I read it from cover to cover and I started the diet and by the next morning, my blood sugar was 100, Since then, I have a fasting reading between the mid 70s and 80s. My doctor was so surprised at the results that,the next week, he took me off the Metformin,I lost 30 pounds in the first month and lost more than 6 inches off my waist and I’m able to work out twice a day while still having lots of energy, The truth i.e can get off the drugs and help myself by trying natural methods。

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  • Rhonda

    In June of 2015, it was discovered that I had type 2 diabetes, By the end of the month, I was given a prescription for Metformin, I stated the ADA diet and followed it completely for several weeks but was unable to get my blood sugar below 140, With no results to how for my hard work, I panicked and called my doctor,His response? Deal with it. I began to feel that something wasn’t right and do my own research. Then I found Rachel’s blog (google ” HOW I FREED MYSELF FROM THE DIABETES ” ) ,I read it from cover to cover and I started the diet and by the next morning, my blood sugar was 100, Since then, I have a fasting reading between the mid 70s and 80s. My doctor was so surprised at the results that,the next week, he took me off the Metformin,I lost 30 pounds in the first month and lost more than 6 inches off my waist and I’m able to work out twice a day while still having lots of energy, The truth i.e can get off the drugs and help myself by trying natural methods。

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Here’s How Mushrooms can Help in the Treatment of Diabetes

Managing glucose better has implications for diabetes, as well as other metabolic diseases

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Mushrooms
How mushrooms can aid in diabetes treatment, Find out here. Pixabay

Eating white button mushrooms daily can act as a prebiotic by improving microbial community in the gut, which could then improve the regulation of glucose in the liver, a finding that could one day pave way for new diabetes treatments, say researchers.

In the study, feeding white button mushrooms to mice changed the composition of gut microbes — microbiota — to produce more short chain fatty acids, specifically propionate from succinate, according to Margherita T. Cantorna, Professor at Pennsylvania State University in the US.

Previous research has shown that succinate and propionate can change the expression of genes needed to manage glucose production, she said.

“Managing glucose better has implications for diabetes, as well as other metabolic diseases,” Cantorna noted.

The study, reported in the Journal of Functional Foods, used two types of mice who were fed about a daily serving size of the mushrooms. One group had microbiota, the other were germ-free.

Mushrooms
Mushrooms. Pixabay

Consuming the mushrooms set off a chain reaction among the gut bacteria, expanding the population of Prevotella — a bacteria that produces propionate and succinate.

These acids can change the expression of genes that are key to the pathway between the brain and the gut that helps manage the production of glucose, or gluconeogenesis.

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The mushrooms, in this case, serve as a prebiotic, which is a substance that feeds beneficial bacteria that are already existing in the gut. Probiotics are live beneficial bacteria that are introduced into the digestive system.

Beyond the possible beneficial benefits of mushrooms as a prebiotic, Cantorna said that this study also shows more evidence that there is a tight connection between diet and microbiota.

“It’s pretty clear that almost any change you make to the diet, changes the microbiota,” Cantorna added. (IANS)