Friday June 22, 2018

Premature birth can be controlled by a Diabetes drug

The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation.

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Diabetes drug can help in blocking premature births. Image Source: daily-sun.com
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  • The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation
  • The mice treated with metformin went on to have full term births, the findings showed
  • Metformin appears to be a potentially safer alternative that works along the same molecular pathway, Dey said

A drug used by millions of people as the frontline treatment for Type-2 diabetes, may also play an unexpected role in blocking a significant cause of preterm birth, say researchers including one of Indian-origin.

“This proof-of-concept study illuminates a potential mechanism behind preterm birth,” said senior author of the study Sudhansu K. Dey, Director of the Division of Reproductive Sciences at Cincinnati Children’s Hospital Medical Center in Ohio, US.

Premature baby. Image Source: www.todaysparent.com
Premature baby. Image Source: www.todaysparent.com

“It also demonstrates possible remedies that are already approved for human use,” Dey noted. The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation.

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The study is important for two reasons, according to the researchers. First, it details a little understood molecular pathway that can lead to premature birth by disrupting the function of the decidua – a thick membrane that lines the uterus and supports the continued growth of developing foetuses.

Mice treated with Metformin. Image Source: www.medpagetoday.com
Mice treated with Metformin. Image Source: www.medpagetoday.com

Second, the researchers demonstrated – in mice — two successful methods for restoring the lining’s function and achieving healthy, full term births. The study involved analysing mice bred to have a condition known to make pregnancies more likely to end in premature birth.

The mice treated with metformin went on to have full term births, the findings showed.

The team also reported similar – but less effective – results when treating mice with resveratrol, an anti-oxidant and anti-aging dietary supplement made from grape seed extract.

Sudhansu K. Dey, Director of the Division of Reproductive Sciences. Image Source: www.cincinnatichildrens.org
Sudhansu K. Dey, Director of the Division of Reproductive Sciences. Image Source: www.cincinnatichildrens.org

In previous studies, Dey and colleagues discovered that rapamycin, an immune suppressing agent, showed promise in mice at preventing preterm birth. However, that medication may be risky for use in pregnant women.

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Metformin appears to be a potentially safer alternative that works along the same molecular pathway, Dey said. Preterm birth can be caused by many factors. It remains unclear how many preterm births are triggered by early decidual ageing, but Dey said it could be a significant number.

Metformin. Image Source: www.canadianpharmacy365.net
Metformin. Image Source: www.canadianpharmacy365.net

The process of preparing and conducting human clinical trials to further test the medications could take several years. (IANS)

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  • Rhonda

    In June of 2015, it was discovered that I had type 2 diabetes, By the end of the month, I was given a prescription for Metformin, I stated the ADA diet and followed it completely for several weeks but was unable to get my blood sugar below 140, With no results to how for my hard work, I panicked and called my doctor,His response? Deal with it. I began to feel that something wasn’t right and do my own research. Then I found Rachel’s blog (google ” HOW I FREED MYSELF FROM THE DIABETES ” ) ,I read it from cover to cover and I started the diet and by the next morning, my blood sugar was 100, Since then, I have a fasting reading between the mid 70s and 80s. My doctor was so surprised at the results that,the next week, he took me off the Metformin,I lost 30 pounds in the first month and lost more than 6 inches off my waist and I’m able to work out twice a day while still having lots of energy, The truth i.e can get off the drugs and help myself by trying natural methods。

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  • Rhonda

    In June of 2015, it was discovered that I had type 2 diabetes, By the end of the month, I was given a prescription for Metformin, I stated the ADA diet and followed it completely for several weeks but was unable to get my blood sugar below 140, With no results to how for my hard work, I panicked and called my doctor,His response? Deal with it. I began to feel that something wasn’t right and do my own research. Then I found Rachel’s blog (google ” HOW I FREED MYSELF FROM THE DIABETES ” ) ,I read it from cover to cover and I started the diet and by the next morning, my blood sugar was 100, Since then, I have a fasting reading between the mid 70s and 80s. My doctor was so surprised at the results that,the next week, he took me off the Metformin,I lost 30 pounds in the first month and lost more than 6 inches off my waist and I’m able to work out twice a day while still having lots of energy, The truth i.e can get off the drugs and help myself by trying natural methods。

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Study: Plant-based Diets Can Help Diabetes Patients

According to the researchers, those with diabetes are two to four times more likely to die from cardiovascular disease than those who do not have diabetes

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Study: Plant-based Diets Can Help Diabetes Patients
Study: Plant-based Diets Can Help Diabetes Patients. Pixabay

Plant-based diets can be beneficial for diabetes as a new study has found that it may improve glycemic control, cholesterol and lead to weight loss in people with Type 2 diabetes.

The researchers suggest that plant-based diets benefit both glycemic control and cardiovascular health because they are low in saturated fat, rich in phytochemicals, high in fibre and often rich in low-glycemic fruits and vegetables.

“The link between diabetes and cardiovascular disease is strong. 60-70 per cent of people who have Type 2 diabetes die of heart disease,” said co-author Hana Kahleova, Director of Clinical Research at the Physicians Committee for Responsible Medicine in Washington DC.

“The good news is that this study shows that the same simple prescription — eating a plant-based diet — can reduce our risk for heart problems and improve Type 2 diabetes at the same time,” Kahleova added.

Representational image.
Representational image. Pixabay

According to the researchers, those with diabetes are two to four times more likely to die from cardiovascular disease than those who do not have diabetes.

For the study, published in the journal Clinical Nutrition, the researchers reviewed nine randomised controlled trials — nearly 700 participants — that assessed the effectiveness of vegan and vegetarian diets for diabetes patients.

Also Read: Study: Diabetes Treatment Gets Boost From ‘Surgery in a Pill’

The results suggested that those who ate a plant-based diet lowered their cholesterol, lost weight, lowered HbA1c levels, and improved other cardiometabolic risk factors when compared to those who ate a non-vegetarian diet.

There was no significant effect on fasting insulin, HDL-C, triglycerides or blood pressure. The overall certainty of evidence was moderate but was low for fasting insulin, triglycerides, and waist circumference. (IANS)