Tuesday October 23, 2018

Premature birth can be controlled by a Diabetes drug

The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation.

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Diabetes drug can help in blocking premature births. Image Source: daily-sun.com
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  • The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation
  • The mice treated with metformin went on to have full term births, the findings showed
  • Metformin appears to be a potentially safer alternative that works along the same molecular pathway, Dey said

A drug used by millions of people as the frontline treatment for Type-2 diabetes, may also play an unexpected role in blocking a significant cause of preterm birth, say researchers including one of Indian-origin.

“This proof-of-concept study illuminates a potential mechanism behind preterm birth,” said senior author of the study Sudhansu K. Dey, Director of the Division of Reproductive Sciences at Cincinnati Children’s Hospital Medical Center in Ohio, US.

Premature baby. Image Source: www.todaysparent.com
Premature baby. Image Source: www.todaysparent.com

“It also demonstrates possible remedies that are already approved for human use,” Dey noted. The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation.

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The study is important for two reasons, according to the researchers. First, it details a little understood molecular pathway that can lead to premature birth by disrupting the function of the decidua – a thick membrane that lines the uterus and supports the continued growth of developing foetuses.

Mice treated with Metformin. Image Source: www.medpagetoday.com
Mice treated with Metformin. Image Source: www.medpagetoday.com

Second, the researchers demonstrated – in mice — two successful methods for restoring the lining’s function and achieving healthy, full term births. The study involved analysing mice bred to have a condition known to make pregnancies more likely to end in premature birth.

The mice treated with metformin went on to have full term births, the findings showed.

The team also reported similar – but less effective – results when treating mice with resveratrol, an anti-oxidant and anti-aging dietary supplement made from grape seed extract.

Sudhansu K. Dey, Director of the Division of Reproductive Sciences. Image Source: www.cincinnatichildrens.org
Sudhansu K. Dey, Director of the Division of Reproductive Sciences. Image Source: www.cincinnatichildrens.org

In previous studies, Dey and colleagues discovered that rapamycin, an immune suppressing agent, showed promise in mice at preventing preterm birth. However, that medication may be risky for use in pregnant women.

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Metformin appears to be a potentially safer alternative that works along the same molecular pathway, Dey said. Preterm birth can be caused by many factors. It remains unclear how many preterm births are triggered by early decidual ageing, but Dey said it could be a significant number.

Metformin. Image Source: www.canadianpharmacy365.net
Metformin. Image Source: www.canadianpharmacy365.net

The process of preparing and conducting human clinical trials to further test the medications could take several years. (IANS)

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  • Rhonda

    In June of 2015, it was discovered that I had type 2 diabetes, By the end of the month, I was given a prescription for Metformin, I stated the ADA diet and followed it completely for several weeks but was unable to get my blood sugar below 140, With no results to how for my hard work, I panicked and called my doctor,His response? Deal with it. I began to feel that something wasn’t right and do my own research. Then I found Rachel’s blog (google ” HOW I FREED MYSELF FROM THE DIABETES ” ) ,I read it from cover to cover and I started the diet and by the next morning, my blood sugar was 100, Since then, I have a fasting reading between the mid 70s and 80s. My doctor was so surprised at the results that,the next week, he took me off the Metformin,I lost 30 pounds in the first month and lost more than 6 inches off my waist and I’m able to work out twice a day while still having lots of energy, The truth i.e can get off the drugs and help myself by trying natural methods。

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  • Rhonda

    In June of 2015, it was discovered that I had type 2 diabetes, By the end of the month, I was given a prescription for Metformin, I stated the ADA diet and followed it completely for several weeks but was unable to get my blood sugar below 140, With no results to how for my hard work, I panicked and called my doctor,His response? Deal with it. I began to feel that something wasn’t right and do my own research. Then I found Rachel’s blog (google ” HOW I FREED MYSELF FROM THE DIABETES ” ) ,I read it from cover to cover and I started the diet and by the next morning, my blood sugar was 100, Since then, I have a fasting reading between the mid 70s and 80s. My doctor was so surprised at the results that,the next week, he took me off the Metformin,I lost 30 pounds in the first month and lost more than 6 inches off my waist and I’m able to work out twice a day while still having lots of energy, The truth i.e can get off the drugs and help myself by trying natural methods。

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Avoid Diabetes With Yoga, Weight Lifting

They studied the effects of weekly time spent on resistance exercise, lower intensity muscular conditioning exercises and aerobic moderate and vigorous physical activity

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Yoga
Avoid Diabetes by practicing Yoga. Pixabay

If you wish to avoid diabetes, better start exercising for just half-an-hour a day, a Harvard University research has found while advising yoga and weight lifting.

According to the research, the chance of developing Type 2 diabetes was cut by between 30 and 40 per cent with just three-and-a-half hours of exercise a week, Daily Mail reported Wednesday.

It was also found that just an hour’s workout every week could cut the risk by 13 percent.

The study, which followed 100,000 women, also showed muscle-strengthening exercises such as yoga and weight lifting fend off the condition.

Scientists showed that those doing at least 150 minutes of aerobic activity a week – and at least an hour of muscle-strengthening – had the best results.

Weight Lifting
Weight Lifting. Pixabay

Published by the journal PLOS Medicine, the study was carried out by scientists from Harvard School of Public Health and the University of Southern Denmark.

Researchers studied 99,316 middle-aged and older women, who did not have diabetes at the beginning of the study, for eight years. During the period, 3,491 women developed Type 2 diabetes.

They studied the effects of weekly time spent on resistance exercise, lower intensity muscular conditioning exercises and aerobic moderate and vigorous physical activity.

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“Our study suggests that engagement in muscle-strengthening and conditioning activities (resistance exercise, yoga, stretching, toning) is associated with a lower risk of (Type 2 diabetes),” the researchers said.

“Despite limitations to which this research can be applied to women in general, it underlines the message that leading an active healthy lifestyle can help to reduce the risk of Type 2 diabetes,” said Richard Elliott, research communications officer at Diabetes, UK. (IANS)