Wednesday December 19, 2018

Premature birth can be controlled by a Diabetes drug

The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation.

1
//
Diabetes drug can help in blocking premature births. Image Source: daily-sun.com
Republish
Reprint
  • The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation
  • The mice treated with metformin went on to have full term births, the findings showed
  • Metformin appears to be a potentially safer alternative that works along the same molecular pathway, Dey said

A drug used by millions of people as the frontline treatment for Type-2 diabetes, may also play an unexpected role in blocking a significant cause of preterm birth, say researchers including one of Indian-origin.

“This proof-of-concept study illuminates a potential mechanism behind preterm birth,” said senior author of the study Sudhansu K. Dey, Director of the Division of Reproductive Sciences at Cincinnati Children’s Hospital Medical Center in Ohio, US.

Premature baby. Image Source: www.todaysparent.com
Premature baby. Image Source: www.todaysparent.com

“It also demonstrates possible remedies that are already approved for human use,” Dey noted. The early-stage study, based on results from mice bred to be prone to premature birth, was published online in JCI: The Journal of Clinical Investigation.

Follow NewsGram on Twitter

The study is important for two reasons, according to the researchers. First, it details a little understood molecular pathway that can lead to premature birth by disrupting the function of the decidua – a thick membrane that lines the uterus and supports the continued growth of developing foetuses.

Mice treated with Metformin. Image Source: www.medpagetoday.com
Mice treated with Metformin. Image Source: www.medpagetoday.com

Second, the researchers demonstrated – in mice — two successful methods for restoring the lining’s function and achieving healthy, full term births. The study involved analysing mice bred to have a condition known to make pregnancies more likely to end in premature birth.

The mice treated with metformin went on to have full term births, the findings showed.

The team also reported similar – but less effective – results when treating mice with resveratrol, an anti-oxidant and anti-aging dietary supplement made from grape seed extract.

Sudhansu K. Dey, Director of the Division of Reproductive Sciences. Image Source: www.cincinnatichildrens.org
Sudhansu K. Dey, Director of the Division of Reproductive Sciences. Image Source: www.cincinnatichildrens.org

In previous studies, Dey and colleagues discovered that rapamycin, an immune suppressing agent, showed promise in mice at preventing preterm birth. However, that medication may be risky for use in pregnant women.

Follow NewsGram on Facebook

Metformin appears to be a potentially safer alternative that works along the same molecular pathway, Dey said. Preterm birth can be caused by many factors. It remains unclear how many preterm births are triggered by early decidual ageing, but Dey said it could be a significant number.

Metformin. Image Source: www.canadianpharmacy365.net
Metformin. Image Source: www.canadianpharmacy365.net

The process of preparing and conducting human clinical trials to further test the medications could take several years. (IANS)

Also Read:

Click here for reuse options!
Copyright 2016 NewsGram

  • Rhonda

    In June of 2015, it was discovered that I had type 2 diabetes, By the end of the month, I was given a prescription for Metformin, I stated the ADA diet and followed it completely for several weeks but was unable to get my blood sugar below 140, With no results to how for my hard work, I panicked and called my doctor,His response? Deal with it. I began to feel that something wasn’t right and do my own research. Then I found Rachel’s blog (google ” HOW I FREED MYSELF FROM THE DIABETES ” ) ,I read it from cover to cover and I started the diet and by the next morning, my blood sugar was 100, Since then, I have a fasting reading between the mid 70s and 80s. My doctor was so surprised at the results that,the next week, he took me off the Metformin,I lost 30 pounds in the first month and lost more than 6 inches off my waist and I’m able to work out twice a day while still having lots of energy, The truth i.e can get off the drugs and help myself by trying natural methods。

SHARE
  • Rhonda

    In June of 2015, it was discovered that I had type 2 diabetes, By the end of the month, I was given a prescription for Metformin, I stated the ADA diet and followed it completely for several weeks but was unable to get my blood sugar below 140, With no results to how for my hard work, I panicked and called my doctor,His response? Deal with it. I began to feel that something wasn’t right and do my own research. Then I found Rachel’s blog (google ” HOW I FREED MYSELF FROM THE DIABETES ” ) ,I read it from cover to cover and I started the diet and by the next morning, my blood sugar was 100, Since then, I have a fasting reading between the mid 70s and 80s. My doctor was so surprised at the results that,the next week, he took me off the Metformin,I lost 30 pounds in the first month and lost more than 6 inches off my waist and I’m able to work out twice a day while still having lots of energy, The truth i.e can get off the drugs and help myself by trying natural methods。

Next Story

New AI Model by Google Can Help Detect Diabetic Retinopathy

For this purpose, it recently launched the "Google AI Impact Challenge"

0
Google
Google's new AI model to help detect diabetic retinopathy. Pixabay

Google has developed an Artificial Intelligence (AI) model that can detect diabetic retinopathy with a level of accuracy on par with human retinal specialists, the technology giant said.

Google is working on “rolling out this diabetic retinopathy initiative in clinics in India with Verily” — an Alphabet-owned company which works on life sciences research and development, Kent Walker, SVP of Global Affairs at Google, wrote in a blog post on Thursday.

More than 400 million people in the world have diabetes. A third of them have diabetic retinopathy — a complication that can cause permanent blindness.

“Using the new assistive technology, doctors and staff can screen more patients in less time, sparing people from blindness through a more timely diagnosis,” Walker said.

While the blindness can be prevented, diabetic retinopathy often goes undetected because people do not always get screenings.

“In major part, this is due to limited access to eye care specialists and staff capable of screening for the disease. This is a problem that AI can help us solve,” Walker said.

“Deploying this technology in underserved communities that don’t have enough eye specialists could be life-changing for many,” Walker added.

Diabetes
Representational image. Pixabay

Google began work on the model in collaboration with eye specialists in India and the US a few years back. They developed an AI system to help doctors analyse images of the back of the eye for signs of diabetic retinopathy.

“The results were promising,” Walker noted, while adding “we should work to make the benefits of AI available to everyone”.

Google has for several years applied AI research and engineering to projects in Asia Pacific with positive societal impact, including stopping illegal fishing in Indonesia, forecasting floods in India, and conserving native bird species in New Zealand, the blog post read.

Also Read- U.S.A: Myanmar’s Military Campaign Against Rohingya Muslims a ‘Mass Genocide’

Besides healthcare, the tech giant also wants to support more Asia Pacific organisations in using AI to help society by engaging with governments, non-profit organisations, universities and businesses.

For this purpose, it recently launched the “Google AI Impact Challenge”.

“Selected organisations who apply to the challenge will receive support from Google’s AI experts and Google.org grant funding from a $25 million pool,” Walker said. (IANS)