Saturday September 21, 2019

Protein Identified Enables New Drugs to Increase ‘Good Cholesterol’ Levels

Importantly, ORP2 could also be targeted to fight cancer. 

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ORP2 could offer a new strategic line of research and possibly succeed where the use of statins in this area hasn't, Yang noted.

Researchers have identified a protein, known as ORP2, responsible for transporting cholesterol inside cells that opens the way for new drugs to increase the body’s ‘good cholesterol’ levels.

ORP2 can increase the amount of cholesterol in cells, a process called cholesterol efflux. We think this pathway will be very important for the development of a drug to increase this good cholesterol, said Rob Yang, Professor from the University of New South Wales in Australia.

Until now, drugs including statins have targeted bad cholesterol (LDL) by inhibiting its synthesis in the liver in an effort to mitigate the risk of heart disease and stroke.

However, while statins are effective at lowering LDL levels, they do little to increase the levels of good cholesterol (HDL) and there is no other drug in use that can significantly boost the human body’s HDL levels.

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Researchers have identified a protein, known as ORP2, responsible for transporting cholesterol inside cells that opens the way for new drugs to increase the body’s ‘good cholesterol’ levels. . VOA

Up to 90 per cent of a cell’s cholesterol is found at the cell’s plasma membrane, said the study published in the journal Molecular Cell.

“Knowing the molecules that deliver cholesterol to the plasma membrane itself is a huge step forward. The transport of cholesterol to the plasma membrane is the key to the generation of HDL.

If such a drug could be developed, it would not replace statins, but would be used complementarily, with one drug used to reduce the bad cholesterol and the other to increase levels of the good, Yang suggested.

Also Read: Number of Students Opting for Science or Tech Are On Rise in India

Importantly, ORP2 could also be targeted to fight cancer.

Cancer, U.S.

Importantly, ORP2 could also be targeted to fight cancer.

The rampant and uncontrolled growth of cells that characterises cancer could be stopped in its tracks by reducing the amount of cholesterol produced.

ORP2 could offer a new strategic line of research and possibly succeed where the use of statins in this area hasn’t, Yang noted. (IANS)

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Physicians Happy While Traders in Shock on Ban on E-Cigarettes in India

With the Union Cabinet directing a blanket ban on e-cigarettes in the country, physicians welcomed the step while e-cigarette traders expressed shock and anger

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e-cigarettes, health, union, ban, india
A man exhales while smoking an e-cigarette, Aug. 28, 2019. VOA

With the Union Cabinet directing a blanket ban on e-cigarettes in the country with complete suspension of their manufacturing, import, export, distribution and storage, physicians welcomed the step while e-cigarette traders expressed shock and anger over the decision.

“Although, e-cigarettes are little less lethal then the conventional cigarettes, we cannot shun away the fact that it contains harmful ingredients. These chemicals can potentially affect the lungs and overall health of the individual in the long run,” Rajesh Chawla, Senior Pulmonologist at Indraprastha Apollo Hospital in New Delhi, told IANS.

Industry body TRENDS which represents importers, distributors and marketers of ENDS, or Electronic Nicotine Delivery Systems in India, termed the decision to ban e-cigarettes “ironic and erratic”.

“This ban on e-cigarettes on the basis of ‘selective sourcing of scientific and medical opinion’ and without holding a single stakeholder meeting is nothing short of a complete murder of democratic norms,” said Praveen Rikhy, Convenor, TRENDS (Trade Representatives of ENDS).

“All our representations sharing best practices from other countries – 70 developed countries have allowed regulated sale of e-cigarettes, have been completely ignored. We will now initiate a formal campaign to help MPs understand the issue, clarify misapprehensions and misinformation spread by lobby groups and support the farmer groups who see the growth of the e-cigarette sector as a global market opportunity for nicotine,” Rikhy said.

e-cigarettes, health, union, ban, india
The Donald Trump administration on September 12 said that it plans to ban the sale of non-tobacco-flavoured e-cigarettes in the US following six deaths. Pixabay

While e-cigarettes have been marketed as a way for adults to quit conventional smoking, a recent outbreak of lung illness associated with use of vaping products in the US has raised concerns about the safety of these products.

The Donald Trump administration on September 12 said that it plans to ban the sale of non-tobacco-flavoured e-cigarettes in the US following six deaths linked to vaping.

Health authorities have documented a total of 450 cases involving e-cigarettes, according to the US Centers for Disease Control and Prevention (CDC), which issued a health warning against vaping.

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“I entirely support the idea of a ban on e-cigarettes; it is a step in the right direction,” Manoj Luthra, CEO, Jaypee Hospital in Noida, told IANS.

“E-cigarettes have been projected as a means to help people to quit smoking tobacco and also being non-polluting. However, these have their own health hazards and are addictive as well. These contain nicotine and other chemical vapours which will certainly have ill effects on the heart and lung and other organs as well,” he said. (IANS)