Friday January 24, 2020

Protein Identified Enables New Drugs to Increase ‘Good Cholesterol’ Levels

Importantly, ORP2 could also be targeted to fight cancer. 

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ORP2 could offer a new strategic line of research and possibly succeed where the use of statins in this area hasn't, Yang noted.

Researchers have identified a protein, known as ORP2, responsible for transporting cholesterol inside cells that opens the way for new drugs to increase the body’s ‘good cholesterol’ levels.

ORP2 can increase the amount of cholesterol in cells, a process called cholesterol efflux. We think this pathway will be very important for the development of a drug to increase this good cholesterol, said Rob Yang, Professor from the University of New South Wales in Australia.

Until now, drugs including statins have targeted bad cholesterol (LDL) by inhibiting its synthesis in the liver in an effort to mitigate the risk of heart disease and stroke.

However, while statins are effective at lowering LDL levels, they do little to increase the levels of good cholesterol (HDL) and there is no other drug in use that can significantly boost the human body’s HDL levels.

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Researchers have identified a protein, known as ORP2, responsible for transporting cholesterol inside cells that opens the way for new drugs to increase the body’s ‘good cholesterol’ levels. . VOA

Up to 90 per cent of a cell’s cholesterol is found at the cell’s plasma membrane, said the study published in the journal Molecular Cell.

“Knowing the molecules that deliver cholesterol to the plasma membrane itself is a huge step forward. The transport of cholesterol to the plasma membrane is the key to the generation of HDL.

If such a drug could be developed, it would not replace statins, but would be used complementarily, with one drug used to reduce the bad cholesterol and the other to increase levels of the good, Yang suggested.

Also Read: Number of Students Opting for Science or Tech Are On Rise in India

Importantly, ORP2 could also be targeted to fight cancer.

Cancer, U.S.

Importantly, ORP2 could also be targeted to fight cancer.

The rampant and uncontrolled growth of cells that characterises cancer could be stopped in its tracks by reducing the amount of cholesterol produced.

ORP2 could offer a new strategic line of research and possibly succeed where the use of statins in this area hasn’t, Yang noted. (IANS)

Next Story

Here Are Some Latest Details About Upcoming Apple iPhone 12

Recently, J.P. Morgan analyst Samik Chatterjee claimed that Apple will release a 5.4-inch iPhone, two 6.1-inch iPhones and one 6.7-inch iPhone with 5G connectivity in 2020

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Apple
Apple is preparing to release a new iPad Pro, a new MacBook and an augmented reality (AR) headset by the first half of 2020. Pixabay

Apple is expected to launch as many as four new iPhones spread across different display sizes in 2020 and now Apple analysts, Macotakara shared more details about the iPhone 12 design from a source from company’s supply chain in Asia.

The report claimed that the iPhone 12 will come in three size versions, including 5.4-inch, 6.1-inch, and 6.7-inch, but Apple will release two distinct 6.1-inch models, according to the source.

The 6.7-inch model will have a thickness around 7.4mm, which would be nearly 10 per cent thinner than the iPhone 11 Pro Max at 8.1mm.

Additionally, it also claims that the 6.7-inch model will be slightly taller than the iPhone 11 Pro Max and feature a triple-lens rear camera.

Recently, J.P. Morgan analyst Samik Chatterjee claimed that Apple will release a 5.4-inch iPhone, two 6.1-inch iPhones and one 6.7-inch iPhone with 5G connectivity in 2020.

Chatterjee predicts the company may introduce two high-end models (one 6.1-inch and one 6.7-inch) with support for mmWave, as well as a triple-lens camera and “world facing” 3D sensing for improved Augmented Reality capabilities.

Earlier Kuo also said that Apple is preparing to release a new iPad Pro, a new MacBook and an augmented reality (AR) headset by the first half of 2020.

Apple
Apple is expected to launch as many as four new iPhones spread across different display sizes in 2020 and now Apple analysts, Macotakara shared more details about the iPhone 12 design from a source from company’s supply chain in Asia. Pixabay

Kuo expects Apple to team up with third parties to create the first batch of AR headsets.

The new iPad Pro models will be launched in the first quarter and will reportedly come with a rear-facing 3D Time-of-Flight sensor for increased accuracy in depth-of-field photography.

ALSO READ: Samsung Unveils Flagship Samsung Galaxy S10 Lite For Rs 39,999

While, a MacBook with a new scissor-switch keyboard could be launched in Q2 2020. (IANS)