Tuesday April 23, 2019

Protein Identified Enables New Drugs to Increase ‘Good Cholesterol’ Levels

Importantly, ORP2 could also be targeted to fight cancer. 

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ORP2 could offer a new strategic line of research and possibly succeed where the use of statins in this area hasn't, Yang noted.

Researchers have identified a protein, known as ORP2, responsible for transporting cholesterol inside cells that opens the way for new drugs to increase the body’s ‘good cholesterol’ levels.

ORP2 can increase the amount of cholesterol in cells, a process called cholesterol efflux. We think this pathway will be very important for the development of a drug to increase this good cholesterol, said Rob Yang, Professor from the University of New South Wales in Australia.

Until now, drugs including statins have targeted bad cholesterol (LDL) by inhibiting its synthesis in the liver in an effort to mitigate the risk of heart disease and stroke.

However, while statins are effective at lowering LDL levels, they do little to increase the levels of good cholesterol (HDL) and there is no other drug in use that can significantly boost the human body’s HDL levels.

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Researchers have identified a protein, known as ORP2, responsible for transporting cholesterol inside cells that opens the way for new drugs to increase the body’s ‘good cholesterol’ levels. . VOA

Up to 90 per cent of a cell’s cholesterol is found at the cell’s plasma membrane, said the study published in the journal Molecular Cell.

“Knowing the molecules that deliver cholesterol to the plasma membrane itself is a huge step forward. The transport of cholesterol to the plasma membrane is the key to the generation of HDL.

If such a drug could be developed, it would not replace statins, but would be used complementarily, with one drug used to reduce the bad cholesterol and the other to increase levels of the good, Yang suggested.

Also Read: Number of Students Opting for Science or Tech Are On Rise in India

Importantly, ORP2 could also be targeted to fight cancer.

Cancer, U.S.

Importantly, ORP2 could also be targeted to fight cancer.

The rampant and uncontrolled growth of cells that characterises cancer could be stopped in its tracks by reducing the amount of cholesterol produced.

ORP2 could offer a new strategic line of research and possibly succeed where the use of statins in this area hasn’t, Yang noted. (IANS)

Next Story

Avoid Smoking During Pregnancy To Prevent Premature Births

The negative health impacts of cigarette smoking during pregnancy, including low birth weight, delayed intrauterine development, pre-term birth, infant mortality, and long-term developmental delays, are well known. 

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The researcher plans to look at quit rates and smoking intensity and their impact on the risk of infant mortality. Pixabay

Expecting mothers, take note. As smoking during pregnancy is linked with negative health outcomes, a team of researchers has found that smoking cessation during pregnancy may reduce the risk of pre-term birth.

The findings, published in the JAMA Network Open journal, showed that the probability of pre-term birth decreased with earlier smoking cessation in pregnancy — up to a 20 per cent relative decrease if cessation occurred at the beginning of pregnancy.

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If we determine quitting, and quitting early, reduces the risk of infant mortality, then that may speak to mothers even more saliently about the importance of smoking cessation. Pixabay

“Of concern, though, given the substantial benefits of smoking cessation during pregnancy is that the proportion of pre-pregnancy smokers who quit smoking during pregnancy has remained essentially stagnant since 2011,” said lead author Samir Soneji from The Dartmouth Institute for Health Policy and Clinical Practice in the US.

For the study, the researchers conducted a cross-sectional study of more than 25 million pregnant women who gave birth to live neonates during a six-year period — measuring their smoking frequency three months prior to pregnancy and for each trimester during pregnancy.

The negative health impacts of cigarette smoking during pregnancy, including low birth weight, delayed intrauterine development, pre-term birth, infant mortality, and long-term developmental delays, are well known.

But the good news is that the proportion of women who start their pregnancy as smokers has been declining in recent years, the researchers said.

smoking

The findings, published in the JAMA Network Open journal, showed that the probability of pre-term birth decreased with earlier smoking cessation in pregnancy — up to a 20 per cent relative decrease if cessation occurred at the beginning of pregnancy. Pixabay

However, the study also found that only about 25 per cent of women who smoked prior to pregnancy were able to quit throughout their pregnancy, and approximately 50 per cent of women who smoked during their pregnancy did so with high frequency (more than 10 cigarettes per day).

The researcher plans to look at quit rates and smoking intensity and their impact on the risk of infant mortality.

Also Read: How Netflix Binge-Watching Can Lead You The “Mean World Syndrome”

“Thankfully most premature babies end up doing well,” he said.

“But premature birth is strongly linked to infant mortality. If we determine quitting, and quitting early, reduces the risk of infant mortality, then that may speak to mothers even more saliently about the importance of smoking cessation,” he added. (IANS)