Saturday October 19, 2019

Researchers Identified Protein Associated With Breast Cancer

In HER2-positive breast cancers, cells with high levels of AXL are more likely to detach from tumours to form metastases.

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High vitamin D harming Breast Cancer, Pixabay

Researchers have found that a protein that, once deactivated, could prevent the spread of an aggressive type of breast cancer to other sites in the body, a process known as metastasis.

In their study, published in the journal Cell Reports, the researchers demonstrated that a protein, AXL, influences the occurrence of metastasis in HER2-positive cancer, an aggressive type that accounts for 20 per cent of breast cancers.

In HER2-positive breast cancers, cells with high levels of AXL are more likely to detach from tumours to form metastases.

Researchers have found that a protein that, once deactivated, could prevent the spread of an aggressive type of breast cancer to other sites in the body, a process known as metastasis.
Representational Image, pixabay

The research was done on mice and with samples of tumour cells taken from cancer patients in Montreal, Canada.

In women with HER2-positive cancer, it was found that the less AXL is present, the better the survival rate.

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Previously, researchers had linked the AXL protein to another type of cancer, triple negative breast cancer, but its role in in HER2-positive cancer was not known.

“Based on this discovery, a treatment targeting AXL could reduce the risk of metastasis,” said one of the researchers Jean-Francois Cote, Professor at Universite de Montreal in Canada. (IANS)

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Being Overweight Before the Age of 40 Can Increase Risk of Cancer in Adults

"The risk increased by 64 per cent for male participants and 48 per cent for females," Bjorge added

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Cancer
Cancer Ribbon. Pixabay

Researchers have found that being overweight before the age of 40 could increase the risk of various cancers in adults.

“Obesity is an established risk factor for several cancers. In this study, we have focused on the degree, timing and duration of overweight and obesity in relation to cancer risk,” said study author Tone Bjorge, Professor at University of Bergen in Norway.

For the findings, published in the International Journal of Epidemiology, the research team wanted to find out how adult overweight (BMI over 25) and obesity (BMI over 30) increase the risk of different types of cancer.

The researchers used data for 2,20,000 individuals from the Me-Can study, with participants from Norway, Sweden and Austria.

Data from health examinations, including information on height and weight, were linked to data from national cancer registries.

Obesity
An overweight woman sits on a chair in Times Square in New York, May 8, 2012. VOA

According to the researchers, 27,881 individuals were diagnosed with cancer during follow-up, of which 9,761 (35 per cent) were obesity-related.

The study showed that if you were overweight before age 40, the risk of developing cancer increases by: 70 per cent for endometrial cancer, 58 per cent for male renal-cell cancer, 29 per cent for male colon cancer and 15 per cent for all obesity-related cancers (both sexes).

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Obese participants (BMI over 30) at the first and second health examination had the highest risk of developing obesity-related cancer, compared to participants with normal BMI.

“The risk increased by 64 per cent for male participants and 48 per cent for females,” Bjorge added. (IANS)