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New York, Sep 25, 2017: Researchers have identified a mechanism that leads to bone loss in older adults, an advance that may help develop therapeutics to treat the age-associated bone loss condition.
Osteoporosis — the thinning of bone and the loss of bone density that increases the risk of fractures — is a major health problem in older people.
Often the condition is accompanied by an increase in fat cells in the bone marrow.
The study led by Yi-Ping Li, Professor at the University of Alabama at Birmingham, found a protein called Cbf-beta which plays a critical role in maintaining the bone-producing cells.
Furthermore, the examination of aged mice showed dramatically reduced levels of Cbf-beta in bone marrow cells as compared to younger mice.
The findings showed when this mechanism malfunctions, progenitor cells stop creating bone-producing cells and instead create fat cells.
Thus, maintaining this Cbf-beta may be essential to prevent human age-associated osteoporosis that is due to elevated creation of fat cells, Li said.
The results were published in the journal Proceedings of the National Academy of Sciences.
Knowledge of this mechanism can provide targets in the search for novel bone-loss therapeutics to treat human osteoporosis with minimal side effects, the researchers noted. (IANS)
By- Salil Gewali
If humanity is hurt, God is hurt.
Follow NewsGram on Facebook to stay updated.The recent unprecedented brutal atrocities upon Hindus in Bangladesh during the holy festival of Durga Puja made each of us more anxious. It should also serve as a wake-up call for West Bengal and Assam. How could one's holy place of worship provoke godless hatred in others? If God-believing people nurture animosity for others, then that religion itself has been wrongly understood or misinterpreted. Who all are to blame? Is there any organisation of rectitude that will come up to address this glaring fault line?
By- Your Service
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The possible exoplanet -- or planets outside of our Solar System -- candidate is located in the spiral galaxy Messier 51 (M51), also called the Whirlpool Galaxy because of its distinctive profile, NASA said in a statement.
Astronomers have, so far, found all other known exoplanets and exoplanet candidates in the Milky Way galaxy, almost all of them less than about 3,000 light-years from Earth.
An exoplanet in M51 would be about 28 million light-years away, meaning it would be thousands of times farther away than those in the Milky Way, NASA said.
"We are trying to open up a whole new arena for finding other worlds by searching for planet candidates at X-ray wavelengths, a strategy that makes it possible to discover them in other galaxies," said Rosanne Di Stefano of the Center for Astrophysics at Harvard and Smithsonian (CfA) in Cambridge, Massachusetts, who led the study.
The findings are published in the journal Nature Astronomy.
The exoplanet candidate was spotted in a binary system called M51-ULS-1, located in M51. This binary system contains a black hole or neutron star orbiting a companion star with a mass about 20 times that of the Sun. The X-ray transit they found using Chandra data lasted about three hours, during which the X-ray emission decreased to zero.
Based on this and other information, the team estimates the exoplanet candidate in M51-ULS-1 would be roughly the size of Saturn and orbit the neutron star or black hole at about twice the distance of Saturn from the Sun.
The team looked for X-ray transits in three galaxies beyond the Milky Way galaxy, using both Chandra and the European Space Agency's XMM-Newton. Their search covered 55 systems in M51, 64 systems in Messier 101 (the "Pinwheel" galaxy), and 119 systems in Messier 104 (the "Sombrero" galaxy).
However, more data would be needed to verify the interpretation as an extragalactic exoplanet. One challenge is that the planet candidate's large orbit means it would not cross in front of its binary partner again for about 70 years, thwarting any attempts for a confirming observation for decades, NASA said.
Named in honor of the late Indian-American Nobel laureate, Subrahmanyan Chandrasekhar, the Chandra X-ray Observatory is the world's most powerful X-ray telescope. It has eight times greater resolution and is able to detect sources more than 20-times fainter than any previous X-ray telescope.
Known to the world as Chandra (which means "moon" or "luminous" in Sanskrit), Chandrasekhar was widely regarded as one of the foremost astrophysicists of the twentieth century. (IANS/JB)
Keywords: NASA, Space, Milky Way galaxy, Solar System, an X-ray telescope.