Tuesday January 21, 2020

Researchers Identify Gene To Prevent And Treat Alcoholism

Researchers discovered that when they increased the levels of the gene encoded protein in mice, they reduced alcohol consumption by almost 50 per cent without affecting the total amount of fluid consumed or their overall well-being.

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The study highlights the importance of using cross-species approaches to identify and test relevant drugs for the treatment of alcohol use disorder. Pixabay

Researchers have identified a gene that could provide a new target for developing medication to prevent and treat alcoholism, according to a new study on mice.

Researchers at Oregon National Primate Research Center (ONPRC) in the US discovered a gene that had lower expression in the brains of non-human primates which voluntarily consumed heavy amounts of alcohol compared to those that drank less.

Furthermore, the team unraveled a link between alcohol and how it modulates the levels of activity of this particular gene.

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The study modified the levels of the protein encoded by a single gene known as GPR39.  Pixabay

Researchers discovered that when they increased the levels of the gene encoded protein in mice, they reduced alcohol consumption by almost 50 per cent without affecting the total amount of fluid consumed or their overall well-being.

The study modified the levels of the protein encoded by a single gene known as GPR39.

The prevalence rates of co-occurring mood and alcohol use disorders are high, with individuals with alcohol use disorder being 3.7 times more likely to have major depression than those who do not abuse alcohol.

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Using a commercially available substance that mimics the activity of the GPR39 protein, the researchers found that targeting this gene dramatically reduced alcohol consumption in mice, showed the findings of the study published in the journal, Neuropsychopharmacology.

“The study highlights the importance of using cross-species approaches to identify and test relevant drugs for the treatment of alcohol use disorder,” noted senior author Rita Cervera-Juanes, Research Assistant Professor at ONPRC. (IANS)

Next Story

Here’s What Filmmaker Shoojit Sircar Suggests For Quitting Social Media Addiction

The filmmaker's thoughts remind us of a dialogue from the 2018 Bengali movie "Uma" directed by Srijit Mukherji

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On the work front, Shoojit Sircar has two movies releasing this year. Wikimedia Commons

At a time when mobile phones and social media addiction are becoming a matter of concern for most of us, filmmaker Shoojit Sircar suggests we should go for detox.

The “Piku” director feels at least when we at a party or a get together, we should try to refrain from clicking selfies and posting them on social media. Instead, we can try striking up a conversation.

Sircar expressed his thoughts on Twitter: “Next time you host a party or a get together, or a general addaa gup shup, ban mobile phones. Don’t let anyone. No selfies no social media just pure human to human gup shup. It’s bliss try it.”

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At a time when mobile phones and social media addiction are becoming a matter of concern for most of us, filmmaker Shoojit Sircar suggests we should go for detox. Wikimedia Commons

The filmmaker’s thoughts remind us of a dialogue from the 2018 Bengali movie “Uma” directed by Srijit Mukherji, where the father (played by Jisshu Sengupta) advises his daughter to stay away from the Internet. When the child protests, the father explains: “It’s neither water nor oxygen. Earlier, we had friends of flesh and blood, not virtual. We shared tiffin, not updates. We followed each other on bicycles, not on Twitter. We liked people and thoughts with our hearts, not clicks.”

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On the work front, Shoojit Sircar has two movies releasing this year. His family comedy drama “Gulabo Sitabo”, starring Amitabh Bachchan and Ayushmann Khurrana, hits theatres on April 17, while the Vicky Kaushal-starrer biographical drama “Sardar Udham Singh” is slated for a Gandhi Jayanti release. (IANS)