Tuesday March 26, 2019

Scientists Develop A New Technique to Measure Blood Clot

The technique, led by the University of Exeter researchers, investigates a part of the blood clotting process which focuses on the ways in which platelets from blood samples clump together.

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The researchers discovered that the enzyme NADPH Oxidase is critically important for the generation of free radicals, the stimulation of blood clotting and the promotion of blood vessel damage in patients. Pixabay

Scientists have developed a new technique that allows them to measure blood clotting as well as the formation of free radicals, that leads to the build-up of blood clots, which in turn cause heart disease, stroke and dementia.

The technique, led by the University of Exeter researchers, investigates a part of the blood clotting process which focuses on the ways in which platelets from blood samples clump together.

“This method may be useful for future studies looking into new anti-platelet treatments for diseases such as diabetes, where clotting is disturbed and increases the risk of heart attack or stroke,” according to the study detailed in the Haematologica journal.

blood
The technique, led by the University of Exeter researchers, investigates a part of the blood clotting process which focuses on the ways in which platelets from blood samples clump together. Pixabay

The researchers discovered that the enzyme NADPH Oxidase is critically important for the generation of free radicals, the stimulation of blood clotting and the promotion of blood vessel damage in patients.

They successfully used the technique in mice and human cells. Their aim is to better understand how blood cells function, which will help to develop new drugs against blood clotting diseases or to test the risk of clotting diseases in patients.

Also Read: Study Claims, There Should Be Treatment Options Given for Miscarriage

“We’re really excited to discover this new technique and its potential to understand how blood vessel diseases develop. For the first time, we can now simultaneously measure blood clotting and the formation of free radicals,” said lead author Giordano Pula, from the Exeter Medical School.

“We know they play a key role in blood vessel damage caused by ageing, diabetes, obesity and chronic inflammation. We’re currently using this technique in our efforts to develop a new treatment to protect the blood vessels in diseases such as heart diseases, stroke, obesity, and vascular dementia,” Pula added. (IANS)

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Sleep For Less Than 6 Hours Increases Health Risk: Study

The research also showed that people who had short or disrupted sleep were also more likely to have metabolic syndrome.

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Less than 6 hours of sleep linked to hardened arteries Pixabay

Sleeping less than six hours or waking up several times in the night is associated with an increased risk of asymptomatic atherosclerosis, which silently hardens and narrows arteries, warns a study.

“Failure to get enough sleep and restlessness during the night should be considered risk factors for blocking or narrowing of the arteries,” said study author Fernando Dominguez of the Spanish National Centre for Cardiovascular Research (CNIC) in Madrid.

The study, presented at the European Society of Cardiology (ESC) Congress 2018 in Munich, Germany, involved nearly 4,000 healthy middle-aged adults who wore a waist band activity monitor for seven days to record sleep quality and quantity.

They were divided into five groups according to the proportion of fragmented sleep, and four groups designating average hours slept a night – less than six (very short), six to seven (short), seven to eight (the reference), and more than eight (long).

Atherosclerosis, sleep
Atherosclerosis, the narrowing of arteries. Flickr

Atherosclerosis, the narrowing of arteries due to plaque build-up on the artery walls, was assessed in leg and neck arteries using three-dimensional ultrasound.

The average age of participants was 46 years and 63 per cent were men.

The researchers found that those in the highest quintile of fragmented sleep were more likely to have multiple sections of arteries with atherosclerosis compared to those in the lowest quintile.

“Studies are needed to find out if sleeping well and long enough can prevent or reverse this effect on the arteries,” Dominguez said.

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The average age of participants was 46 years and 63 per cent were men.
Pixabay

“In the meantime, it seems sensible to take steps to get a good night’s sleep — such as having a physically active lifestyle and avoiding coffee and fatty foods before bedtime,” Dominguez added.

Also Read: There’s No Healthy Level for Consuming Alcohol, Lancet Study Confirms

The research also showed that people who had short or disrupted sleep were also more likely to have metabolic syndrome, which refers to the combination of diabetes, high blood pressure, and obesity, and depicts an unhealthy lifestyle. (IANS)