Monday March 18, 2019

Scientists hopeful of ‘full-length single chain’ AIDS vaccine

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www.pbs.org

NewsGram Staff Writer

Robert Gallo, the scientist who first proved in 1984 that HIV triggered the disease AIDS, is again all set to begin the trial of its vaccine in the US. The vaccine which has been developed over the past 15 years by Gallo is a little different and is expected to bear fruitful results.

The initial phase, involving 60 volunteers, will test the safety and immune responses of the vaccine. This study will reveal whether the vaccine is more effective than the other 100+ AIDS vaccines that have been tested over the last three decades. Extensive testing on monkeys have yielded positive results.

Despite the presence of potential vaccines, the challenge with AIDS is that HIV directly infects white blood cells (RBC) called T-cells, so it literally turns our immune system against us. So, once the virus enters a T-cell, it’s invisible to the immune system.

The sole possibility to combat the threat is to pump in antibodies against the HIV surface proteins. However, doing so is equally difficult owing to the fact that the retrovirus can regularly change its viral envelope to hide particular surface proteins.

But Gallo and his team at the Institute of Human Virology in USA believe that they may have now found a moment when the HIV surface protein, known as gp120, is vulnerable to detection – the moment the virus binds with our bodies’ T-cells.

When HIV infects a patient, it first links to the CD4 receptor on the white blood cell. It then transitions, exposing hidden parts of its viral envelope, which allow it to bind to a second receptor called CCR5. Once HIV is attached to both these T-cell receptors, it can successfully infect the immune cell. at this stage, it is impossible to stop its juggernaut.

Gallo’s “full-length single chain” vaccine contains the HIV surface protein gp120, engineered to link to a few portions of the CD4 receptor. The motive is to fuel antibodies against gp120 when it is already attached to CD4 and is in a vulnerable transitional state. The aim of the whole process is effectively stopping it from attaching to the second CCR5 attachment.

Gallo himself admitted to Jon Cohen over at Science that full-length single chain vaccine is a “terrible name”.

The trial is being run in collaboration with Profectus BioSciences, a biotech spin-off from the Institute of Human Virology, and Gallo explained that extreme thorough testing on monkey and getting the fund to develop a human-grade vaccine have resulted in a delay to get to this point.

“Was anything a lack of courage?” he asked Science. “Sure. We wanted more and more answers before going into people.”

Let’s hope that caution pays off, and we may finally have a viable contender for an AIDS vaccine on our hands.

(With inputs from www.sciencealert.com)

Next Story

Biotechnology Can Meet The Growing Energy Needs Of Rural India

The Indian economy also has a distinct advantage with respect to its demography that can ensure sustained growth for the sector.

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Indian biotechnology industry has flourished over the years. As of 2016, India had over a thousand biotechnology start-ups. Pixabay

Over the last two-to-three decades, the major success story of the Indian economy has been the stellar growth of its IT industry. But as the dividends from the sector reach the eventual inflection point, India needs to build similar competencies in other industries to ensure sustained growth and prosperity.

It is not acknowledged as often but the biotechnology industry seemed poised to take over the mantle. In the span of a decade beginning in 2007, the industry has grown exponentially in size from about $2 billion to over $11 billion in terms of revenue. By 2025, it is targeted to touch $100 billion.

The biotechnology industry, however, has been impacting Indian lives long before it grew so much in size. Back in the mid-1960s, advancements in biotechnology drove the Green Revolution, which enhanced farm yields and made the country self-sufficient in food production.

A similar contribution from the sector was witnessed in the White Revolution when India became a milk-surplus nation and improved the nutrition level of its citizens.

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However, a few challenges need to be addressed if India is to fuel the growth of its biotechnology industry and achieve its target of making it a $100 billion industry by 2025. Pixabay

More recently, the meteoric growth of the Indian pharmaceutical industry is a result of process innovation that has given the country a cost advantage in the manufacture of drugs.

Further, the growing energy needs of India’s rural areas have been increasingly met by biomass fuel.

These outcomes have been the result of years of concerted efforts by the Indian government to enable the growth of the industry. As early as 1986, Rajiv Gandhi, recognising the potential of biotechnology in the country’s development, set up the Department of Biotechnology, making India one of the first countries in the world to have a government department solely dedicated to biotechnology.

Over the years, the Department of Biotechnology has set up 17 Centres of Excellence at higher education institutions across the country and has supported the establishment of eight biotechnology parks across different cities. The biggest contribution of the department has been in setting up of the Biotechnology Industry Research Assistance Council (BIRAC) in 2012, which has successfully supported 316 start-ups in its six years of existence.

Due to these efforts, the Indian biotechnology industry has flourished over the years. As of 2016, India had over a thousand biotechnology start-ups. To put matters in perspective, Australia has a total of 470 biotechnology companies. More than half of these start-ups are involved in healthcare – drugs, medical devices and diagnostics – while about 14 per cent are in agricultural biotechnology and about 18 per cent in biotechnology services.

The Indian economy also has a distinct advantage with respect to its demography that can ensure sustained growth for the sector. More than half the Indian population is below the age of 25. On a global scale, the median age in India (26.5 years) is much below that of China (35.9 years) and the US (37.1 years). An effective utilisation of this demographic advantage will provide India a competitive edge over all other emerging economies in the advancement of biotechnological research and development.

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he industry argues that India’s stricter standards for patents discourages innovation and dampens foreign investment. Pixabay

However, a few challenges need to be addressed if India is to fuel the growth of its biotechnology industry and achieve its target of making it a $100 billion industry by 2025. First, India’s research and development expenditure is quite low at 0.67 per cent of GDP, not only compared to mature biotechnology economies such as Japan and the US (which stands at around 3 per cent) but also in comparison to emerging economies like China (which is at around 2 percent).

Second, and more specific to the biotech pharmaceutical sector, there are a few India-specific challenges with the country’s IP regime. There are two main areas of contention for the industry in India’s approach to intellectual property. The first issue lies in Section 3(d) of the Patents (Amendment) Act, 2005, which sets a higher standard for patentability than mandated by TRIPS. The industry argues that India’s stricter standards for patents discourages innovation and dampens foreign investment. The second issue is that of compulsory licensing, which gives the government power to suspend a patent in times of health emergencies. Although India has used this option only once, the industry feels that such regulations keep investors clear of Indian markets.

A third challenge lies in the risk involved in the Valley of Death, that is, the risk of failure in the transition of innovative products and services from discovery to marketisation. Most of the early research funding, often provided by universities or the government, runs out before the marketisation phase, the funding for which is mostly provided by venture capitalists. It becomes difficult to attract further capital between these two stages because a developing technology may seem promising, but it is often too early to validate its commercial potential. This gap has a huge impact in commercialisation of innovative ideas.

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Thus, the Indian government needs to act on these challenges facing the biotechnology sector. An increase in investment towards research and development and building human capital is the most crucial point of action. These initiatives have shifted growth trajectories of countries like China away from India. As for the challenging IP regime, the government needs to come together with the biopharma industry and chalk out a middle ground that recognises the value of innovation and does not hurt its investment attractiveness. Finally, for the Valley of Death concerns, the government can build a mechanism where funding can be provided for select innovative ideas based on their national importance. Only such action-oriented steps can make biotechnology the next success story of the Indian economy. (IANS)