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Scientists Unveil a Tool That Can Predict Eye, Hair and Skin Color From DNA Sample

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DNA
New ML-tool uses DNA to predict height and cancer risk. Pixabay

Researchers have developed a novel web tool that can accurately predict eye, hair and skin color from even a small DNA sample, an advance that can be used when standard forensic profiling is not helpful.

The “HIrisPlex-S DNA test” system is capable of generating all three pigment traits from human biological material together using a freely available web tool.

The tool is designed to be used when standard forensic DNA profiling is not helpful because no reference DNA exists against which to compare the evidence sample.

The study, conducted on mice, found that genetic variations in the genes that codes for protein POU6F2 may affect the structure of the eye and increase a person's risk of glaucoma. Pixabay
Eye, representational image. pixabay

“We have previously provided law enforcement and anthropologists with DNA tools for eye colour and for combined eye and hair colour, but skin colour has been more difficult,” said Susan Walsh, forensic geneticist at the Indiana University-Purdue University Indianapolis in the US.

Users, such as law enforcement officials or anthropologists, can enter relevant data using a laboratory DNA analysis tool, and the web tool will predict the pigment profile of the DNA donor.

“Importantly, we are directly predicting actual skin colour divided into five subtypes — very pale, pale, intermediate, dark and dark to black — using DNA markers from the genes that determine an individual’s skin coloration.

"This study provided evidence that fasting induces a metabolic switch in the intestinal stem cells, from utilizing carbohydrates to burning fat," said David Sabatini, an MIT professor of biology and the paper's another senior author.
DNA, Pixabay

“If anyone asks an eyewitness what they saw, the majority of time they mention hair colour and skin colour. What we are doing is using genetics to take an objective look at what they saw,” Walsh said.

Also Read: This DNA Test Can Screen Your Baby For 193 Genetic Diseases

The results are published in the journal, Forensic Science International: Genetics.

The innovative high-probability and high-accuracy complete pigmentation profile web tool is available online without charge, the researchers said. (IANS)

Next Story

Novel DNA Tool Can Help You Trace Your Origins to Vikings

The researchers found that ancient genomes typically consist of hundreds of thousands and sometimes millions of markers

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DNA
New DNA tool can trace your origins to Vikings, Pixabay

Think, that your ancestors were Roman Britons, Vikings or ancient Israelites? A new DNA tool can help you trace your similarity to these ancient people who once roamed the earth, say researchers.

Currently the study of ancient DNA requires a lot of information to classify a skeleton to a population or find its biogeographical origins.

But, scientists from the UK’s University of Sheffield, defined a new concept called Ancient Ancestry Informative Markers (aAIMs) — a group of mutations that are sufficiently informative to identify and classify ancient populations.

They found that the identification of a small group of aAIMs that can be used to classify skeletons to ancient populations.

“We developed a new method that finds aAIMs efficiently and have proved that it is accurate,” said lead author Eran Elhaik, from Sheffield’s Department of Animal and Plant Sciences.

The new tool identifies aAIMs by combining traditional methodology with a novel one that takes into account a mixture.

DNA double helix
DNA double helix. Wikimedia

People are currently unable to trace their primeval origins because commercial microarrays, such as the ones used for genetic genealogy, do not have relevant markers.

But aAIMs is like finding the fingerprints of ancient people, Elhaik noted.

“It allows testing of a small number of markers – that can be found in a commonly available array – and you can ask what part of your genome is from Roman Britons or Viking, or Chumash Indians, or ancient Israelites, etc,” he explained.

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“We can ask any question we want about these ancient people as long as someone sequenced these ancient markers.”

The researchers found that ancient genomes typically consist of hundreds of thousands and sometimes millions of markers.

“We demonstrated that only 13,000 markers are needed to make accurate population classifications for ancient genomes and while the field of ancient forensics does not exist yet, these aAIMs can help us get much closer to ancient people,” Elhaik said. (IANS)