Sunday January 26, 2020

Study Shows That Drug to treat bleeding may benefit some stroke patients

A drug, currently used to treat blood loss from major trauma and bleeding after childbirth, may benefit patients with stroke caused by bleeding in the brain -- intracerebral haemorrhage, a clinical trial suggests.

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Children and adults treated with oral antibiotics may have a higher risk of developing kidney stones, according to a new study.
Antibiotics, Pixabay

A drug, currently used to treat blood loss from major trauma and bleeding after childbirth, may benefit patients with stroke caused by bleeding in the brain — intracerebral haemorrhage, a clinical trial suggests.

Intracerebral haemorrhage occurs when a diseased blood vessel within the brain bursts, allowing blood to leak inside the brain.

The study, published in the journal The Lancet, found that giving tranexamic acid (TXA) to people who had experienced intracerebral haemorrhage reduced the number of deaths in the early days following the stroke.

It also showed that both the amount of bleeding in the brain and the number of associated serious complications were lower in the patients who had received the TXA treatment, the researchers from the University of Nottingham said.

 

For the study, researchers recruited more than 2,000 patients who were diagnosed as having had bleeding in the brain -- confirmed by CT scan -- from 124 hospitals in 12 countries between 2013 and 2017.
representational image, Pixabay

Patients who received TXA treatment experienced lower associated serious complications — such as pneumonia and brain swelling — as compared to those who had not, the researchers added.

 

However, the trial found no difference in the number of people who were left disabled or had died at three months after their stroke — the study’s primary outcome.

“While we failed to show significant benefits three months after stroke, the reduction in early deaths, amount of bleeding on the brain and serious complications are signs that this drug may be of benefit in the future,” said co-author Nikola Sprigg, Professor at the University of Nottingham.

For the study, researchers recruited more than 2,000 patients who were diagnosed as having had bleeding in the brain — confirmed by CT scan — from 124 hospitals in 12 countries between 2013 and 2017.

They were randomly sorted into two patient groups — one received TXA within eight hours of their stroke and another was given a saline placebo.

Also Read: Study Shows That 3 Cups of Coffee or Tea Daily May Cut Risk of Stroke

CT scans of the patients’ brains were performed 24 hours after their stroke and their progress was monitored and measured at day two and day seven after their stroke. The final follow up was performed at 90 days.

The researchers have highlighted the need for further studies to find out whether giving an earlier dose of TXA might be beneficial for patients. (IANS)

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Stroke Patients At a Risk of Suffering From Heart Attack: Study

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Heart attack
Stroke Patients more likely to have a heart attack or another major cardiovascular event within thirty days of having a stroke. Pixabay

Both women and men are significantly more likely to have a heart attack or another major cardiovascular event, according to a new study.

The research, published in the journal Stroke, demonstrated for the first time that in people with no underlying heart disease, after a stroke they were more than 20 times more likely than those who didn’t have a stroke (23-fold in women and 25-fold in men) to have a first-in-life major adverse cardiovascular event.

These events include things like heart attack, chest pain, cardiac failure or cardiac death.

This risk dropped after 30 days, but even one year after a stroke, men and women both still had twice the risk of a major cardiac event than those who didn’t have a stroke, according to the study.

“This shows that after taking risk factors into consideration, having experienced a recent stroke was independently associated with the incidence of major adverse cardiac events,” said study researcher Luciano Sposato, Associate Professor at Western University in Canada.

Heart attack
Stroke Patients may suffer from heart attack, chest pain, cardiac failure or cardiac death. Pixabay

“This leads us to believe that there are underlying mechanisms linked to stroke that may be causing heart disease,” Sposato added.

For the findings, the research team examined ICES data for more than 90,000 adults over the age of 65 in Ontario with no pre-existing clinical diagnosis of heart disease.

The researchers examined the incidence of cardiac events in two groups – a group of just over 20,000 that had a stroke and a group of approximately 70,000 individuals without stroke but with similar vascular risk factors, comorbidities and demographic characteristics.

In a paper published earlier in 2019, Sposato and collaborators used animal models to back up this finding by demonstrating that the brain damage caused by stroke leads to inflammation and scarring in the left atrium of the heart.

Also Read- Women Who Have Less Sex Experience an Early Menopause: Study

These changes are well-known structural abnormalities for a number of heart diseases such as heart attacks, heart failure and cardiac arrhythmias.

The researchers hope this information will inform clinical practice and encourage health care providers to watch for cardiovascular symptoms in patients who recently had strokes. (IANS)