Thursday February 21, 2019

Study Shows That Drug to treat bleeding may benefit some stroke patients

A drug, currently used to treat blood loss from major trauma and bleeding after childbirth, may benefit patients with stroke caused by bleeding in the brain -- intracerebral haemorrhage, a clinical trial suggests.

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Children and adults treated with oral antibiotics may have a higher risk of developing kidney stones, according to a new study.
Antibiotics, Pixabay

A drug, currently used to treat blood loss from major trauma and bleeding after childbirth, may benefit patients with stroke caused by bleeding in the brain — intracerebral haemorrhage, a clinical trial suggests.

Intracerebral haemorrhage occurs when a diseased blood vessel within the brain bursts, allowing blood to leak inside the brain.

The study, published in the journal The Lancet, found that giving tranexamic acid (TXA) to people who had experienced intracerebral haemorrhage reduced the number of deaths in the early days following the stroke.

It also showed that both the amount of bleeding in the brain and the number of associated serious complications were lower in the patients who had received the TXA treatment, the researchers from the University of Nottingham said.

 

For the study, researchers recruited more than 2,000 patients who were diagnosed as having had bleeding in the brain -- confirmed by CT scan -- from 124 hospitals in 12 countries between 2013 and 2017.
representational image, Pixabay

Patients who received TXA treatment experienced lower associated serious complications — such as pneumonia and brain swelling — as compared to those who had not, the researchers added.

 

However, the trial found no difference in the number of people who were left disabled or had died at three months after their stroke — the study’s primary outcome.

“While we failed to show significant benefits three months after stroke, the reduction in early deaths, amount of bleeding on the brain and serious complications are signs that this drug may be of benefit in the future,” said co-author Nikola Sprigg, Professor at the University of Nottingham.

For the study, researchers recruited more than 2,000 patients who were diagnosed as having had bleeding in the brain — confirmed by CT scan — from 124 hospitals in 12 countries between 2013 and 2017.

They were randomly sorted into two patient groups — one received TXA within eight hours of their stroke and another was given a saline placebo.

Also Read: Study Shows That 3 Cups of Coffee or Tea Daily May Cut Risk of Stroke

CT scans of the patients’ brains were performed 24 hours after their stroke and their progress was monitored and measured at day two and day seven after their stroke. The final follow up was performed at 90 days.

The researchers have highlighted the need for further studies to find out whether giving an earlier dose of TXA might be beneficial for patients. (IANS)

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Researchers Discover Novel Drug to Delay Ageing

Besides, the blood chemistry of the mice that underwent drug treatment was also found to have no adverse effects as it was similar to the untreated mice

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Go Makeup Free Once a Week to Delay Ageing
Go Makeup Free Once a Week to Delay Ageing. (Wikimedia commons)

Researchers, including one of Indian origin, have developed a new drug that can delay ageing demonstrated by declining muscle mass, strength and function.

As human bodies age, they increasingly lose the ability to repair and rebuild degenerating skeletal muscles. This can dramatically limit the ability of older adults to live fully active and independent lives.

In the study, researchers from the University of Texas Medical Branch (UTMB) at Galveston identified a protein called Nicotinamide N-methyltransferase (NNMT) in muscle stem cells that appears to be responsible for the age-related dysfunction.

They developed a small molecule drug, NNMT inhibitor (NNMTi), which when prescribed to aged mice could limit NNMT’s effects as well as significantly increase muscle size, strength and metabolic state in the animals.

By resetting muscle stem cells to a more youthful state, the mice could be rejuvenated so that they could more effectively repair muscle tissues, the researchers explained.

“There are no treatments currently available to delay, arrest or reverse age-related muscle degeneration,” said Harshini Neelakantan, research scientist at UTMB.

Makeup can speed up the process of ageing.
Slow down skin ageing by this drug. Pixabay

“These initial results support the development of an innovative drug treatment that has the potential to help the elderly to become fitter, faster and stronger, thus enabling them to live more active and independent lives as they age,” she added.

For the study, published in Biochemical Pharmacology, the team treated ageing mice, suffering from muscle injury, with the drug or a placebo.

Following seven days of treatment, researchers saw that the aged mice, which received the drug, had more functional muscle stem cells than the placebo mice.

Also Read- Social Media Giant Facebook Accused of Revealing Sensitive Health Data

Moreover, the size of the muscle fibres doubled and the strength also increased significantly.

Besides, the blood chemistry of the mice that underwent drug treatment was also found to have no adverse effects as it was similar to the untreated mice. (IANS)