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A radiologist examines the brain X-rays of a patient. In a small study, patients with brain tumors were given genetically modified poliovirus, which helped their bodies attack the cancer. VOA

There’s an exciting new breakthrough in treating some types of deadly brain tumors, that uses, of all things, a polio virus. Doctors at Duke Health in North Carolina genetically altered the virus because it produces such a strong immune response in our bodies. The result is a longer life for patients whose brain cancer returned. All had glioblastoma, an aggressive and lethal type of brain cancer. Of the 61 patients in the study, 21 percent who got this new treatment had were alive three years later.

While that number is low, the survival rate for glioblastoma is normally even lower, usually, a year and a half after diagnosis. The researchers compared the study group to a group of patients drawn from historical cases at Duke. Only four percent of these patients survived three years after treatment.

Dr. Annick Desjardins, one of the authors, said not all patients respond, but if they do, they often become long-term survivors. Desjardins said, “The big question is, how can we make sure that everybody responds?”

Stephanie Hopper was the first patient in the Duke study. She was diagnosed with glioblastoma eight years ago. She had the tumor removed, but two years later, it returned. The modified virus is directly injected into the brain during surgery. After treatment, Hopper’s tumor shrunk to the point where it’s barely noticeable in her brain scans, and the tumor is continuing to shrink.

Dr. Darell Bigner is the senior author of the study which was published in the New England Journal of Medicine. He explained that by modifying the virus, it destroyed its ability to infect nerve cells and cause polio, but the virus retained the ability to kill cancer cells. In fact, the modified virus targeted the tumor cells.

Prior to the study, the researchers decided they needed a different approach to treating glioblastomas which is why they looked at experimenting with the polio virus.

There’s an exciting new breakthrough in treating some types of deadly brain tumors, that uses, of all things, a polio virus. Doctors at Duke Health in North Carolina genetically altered the virus because it produces such a strong immune response in our bodies. Flickr

One of the goals of a phase one trial is to find a dose that is safe. In some patients, the therapy caused their brains to swell and they experienced seizures and other bad side effects so the dose was lowered. Study participants were selected according to the size of their recurring tumor, its location in the brain and other factors designed for patient protection.

For five of the 61 patients in the trial, the cancer returned. They were treated a second time and Bigner says, “Those that we’ve been able to follow long enough have responded to the treatment the second time. That’s extremely important.” Combining the polio virus with other approved therapies is one approach already being tested at Duke to improve survival.

Also read: A One-Shot Nanoparticle Vaccine for Polio is Developed by MIT scientists

The researchers are continuing their work on treating glioblastomas and planning other studies as well. They want to test the therapy on children’s brain tumors. The therapy may also expand beyond brain tumors to include breast cancer and melanoma patient as well. (VOA)


Photo by Jonathan Borba on Unsplash

With the baby keeping you busy all day and night, your skincare takes a backseat.

When you become a mother, you tend to forget about your own needs because you are so focused on your child. With the baby keeping you busy all day and night, your skincare takes a backseat. It's not always changes in skin texture and looks post-pregnancy are a bad thing, but not taking care of your skin may lead to acne, melasma, stretch marks, puffy eyes, and even dark circles. Syed Nazim, Dermatologist, Aesthetic and Hair Transplant Surgeon, Royal Lush Skin Clinic Saket, New Delhi, shares simple and easy tips for you to follow, to get a glowing post-pregnancy.

* Cleansing: As you sleep, your skin goes through a renewal cycle, by dispensing toxins and debris. So you only need a light-textured cleanser to wash your face with a face wash that is suitable for your skin type.

* Steam: Take steam for 2-3 days a week, it will help you to open up your clogged pores.

* Scrub & face pack: Use a face scrub, to remove the dead skin cells, scrub your face for like 5 minutes and wash it with normal tap water. It will help you to make your skin softer and radiant, leave the mask until it dries off.

* Toner & moisturizer: Apply toner to your face, look for clarifying toners that rebalance your pH to maintain the pH value of your skin. In the end, you only have to moisturize your face, to give hydration.

* Steal baby products: Baby products are always mild in nature so that the baby's sensitive skin doesn't have to compromise. They are created to lock moisture in babies skin. So, you can also use them. Whether it's a body oil, lotion or cream, apply some on your skin every time you're applying them on your baby. If you do this, you can flaunt your skin, this way, you don't have to dedicate a specific time every day for your skincare.

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Photo by Valeriia Kogan on Unsplash

Colorless chemicals were developed and mixed in varying ratios to dye hair.

A couple of years ago, finding a strand of grey hair meant visiting the parlor to cover it up. Women and men refused to admit their age, and refused to let it show. Be it moustache, eyebrows, or hair on the head, it was dyed a luscious black, or reddish-brown for those who wanted to go natural. Today, the trend of coloring hair has nothing to do with age. Young boys and girls sport bright colors and hairstyles, which is now a marker of how modern one can be.

This notion of modernity associated with neon streaks and an almost gothic look originates from the ancient Egyptian civilization, where it was considered fashionable to look different from the natural features one was born with. Kohl, lipstick, perfume, and makeup were the inventions of those who hoped to live even after death. Likewise, they were the first people to discover hair dye. Initially, they dyed their hair black, to cover the grey. They used compounds that were extracted from plants, but some of them were lethal. So, they took to extracting the color from fermented leeches.

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Photo by Wikimedia Commons

One of the bookshop at Daryaganj, Chandni Chowk, Delhi.

The history of Daryaganj goes back to the era of Mughal dynasty, and so its history is as old as the old city of Shahjahanabad, now Chandni Chowk. Interestingly, this market was known as Faiz Bazaar in the Mughal era and was considered as an important commercial place.

In fact, at that time this area was very posh, and had beautiful houses on both sides of a stream from a hauz (meaning, water storage tank) flowing down the centre. Not only this, trees were lined up for shade and it looked like a marvellous garden had been turned into a market.

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