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Toxicity reduces if drugs are delivered as liquid salt through skin

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New York: Researchers say that formulating drugs as liquid salts may provide a safe and efficient strategy for topical delivery of drugs that cause skin toxicity. The researchers who brought out the findings also included one of Indian-origin.

A novel formulation of the drug propranolol as a liquid salt enables delivery through the skin with reduced toxicity, the findings showed.

“Propranolol is positively charged which is a likely source of its toxicity. Shielding of this charge by association with a counter species in the liquid salt reduces its toxicity. These findings are broadly applicable to many charged drugs” said study senior author Samir Mitragotri, a professor at the University of California, Santa Barbara in the US.

Skin toxicity remains a major challenge in the design and use of new topical drug formulations. Many drugs must be dissolved in organic solvents which are typically toxic to the skin.

Many drugs such as propranolol itself show dose-dependent skin toxicity. Formulating drugs as liquid salt mitigates both sources of toxicity.

Given their fluid nature, liquid salts eliminate the necessity of organic solvents. In addition, counter ions used to form the liquid salts shield the drug charge, which further reduces drug-induced toxicity.

The researchers said that this is the first study that reports the design of liquid salts to minimise skin toxicity. Such formulations can increase the spectrum of drugs that can be safely delivered via a transdermal patch.

“This technology presents an exciting new, patient compliant solution for treating diseases,” study co-author Michael Zakrewsky from University of California, Santa Barbara. (IANS), (image courtesy: irp-cdn.multiscreensite.com)

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Study Warns Patients That Now Drugs Contain Inactive Ingredient

Drugs can contain inactive compounds like gluten, lactose or specific dyes that can cause a reaction in certain patients

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FILE - Drugs can contain inactive compounds like gluten, lactose or specific dyes that can cause a reaction in certain patients. VOA

A new study is warning patients that if they feel worse after taking a new medication, it might not be because of the drug but rather an inactive ingredient in it.

The report published Wednesday in Science Translational Medicine says medications often contain “inactive” ingredients that can cause allergic reactions or gastrointestinal reactions in people sensitive to specific compounds.

Drugs can contain inactive compounds like gluten, lactose or specific dyes that can cause a reaction in certain patients.

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Drugs can contain inactive compounds like gluten, lactose or specific dyes that can cause a reaction in certain patients. Pixabay

“There’s a tremendous underappreciation of the potential impact that inactive ingredients may have,” said Dr. Giovanni Traverso, a gastroenterologist who spurred the research after his celiac patient’s trouble with medication that contained gluten as an inactive compound.

The study analyzed data on inactive ingredients from a database of more than 42,000 prescription and over-the-counter medicines. It found that an average pill contains eight inactive ingredients, but some contain 20 or even more.

ALSO READ: Longer Exposure to PM2.5 Raises Risk of Diabetes: Study

While most of the worrisome ingredients are in small amounts in most medications, the researchers pointed out that 39 percent of seniors take at least five prescription medicines daily, so even the tiniest amount can add up.

Drug manufacturers already put warnings on medications that contain refined peanut oil. And the U.S. Food and Drug Administration is considering a proposal that recommends adding gluten information to drug labels. (VOA)