Saturday February 16, 2019

What Causes Alcohol Addiction?

The team analysed GAT-3 levels in brain tissue from deceased humans who had documented alcohol addiction

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What Causes Alcohol Addiction?
What Causes Alcohol Addiction? (IANS)

Molecular mechanisms including lower levels of a protein in the brain may be the reason why addicts choose alcohol over an alternative reward, finds a study that may help improve treatment for alcohol dependence.

The study suggested that the level of a transporter protein GAT-3, situated in the amygdala region of the brain — responsible for emotional reactions — was lower among the alcohol addicts.

“We have to understand that a core feature of addiction is that you know it is going to harm you, potentially even kill you, and nevertheless something has gone wrong with the motivational control and you keep doing it,” said Markus Heilig from the Linkoping University in Sweden.

In the study, published in the journal Science, the team used a mouse model to measure the expression of hundreds of genes in five areas of the brain.

What Causes Alcohol Addiction?
Alcoholic beverages. Pixabay

The team investigated the role of reduced GAT-3 levels in rats that initially preferred sweetened water over alcohol. After the reduction, they were again presented with the choice between alcohol and sugar.

They found that 15 per cent of the outbred rats chose alcohol over a high-value reward.

Also Read: US Cancels A Planned Alcohol Study Over Trust Issues

“Decreasing the expression of the transporter had a striking effect on the behaviour of these rats. Animals that had preferred the sweet taste over alcohol reversed their preference and started choosing alcohol,” said lead investigator Eric Augier.

Further, the team analysed GAT-3 levels in brain tissue from deceased humans who had documented alcohol addiction. They found lower levels of the protein in them than in the control individuals. (IANS)

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The Craft of Distilling Is Ancient, Different Story Behind Every Bottle

The craft of distilling is very ancient and recipes have been handed down generations. To me, food and spirits are very culture-centric and each dish or drink is an experience of this culture and have a lot of story to it.

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The aim is for the curated audience to meet curated brands and learn about their stories. We consciously wanted to create a small, well-curated festival that encourages such conversations amongst the visitors," Prakash elaborated. Pixabay

Every bottle of alcohol has a tale to tell and to celebrate this, over 20 international masters, distillers, mixologists and story tellers will gather in Mumbai over the weekend on a platform that celebrates the craft of distillers and distilleries. It will also be a rite of passage for the new consumer who is open to experiencing luxury beverages that are a product of passion and commitment and are produced in small batches, without any compromise on quality.

“Every bottle has a tale, waiting to be shared – of its founder, of the distiller, of the wood in which it lay, of the people who built the spirit, of the mixologist who decided to `play’ with it and more. Listen, learn and celebrate the people behind the spirits,” Keshav Prakash, who began his career as an advertising filmmaker and then travelled the world to discover the world of fine spirts, told IANS of The Vault Biennale at the Mahalakshmi Race Course.

“The craft of distilling is very ancient and recipes have been handed down generations. To me, food and spirits are very culture-centric and each dish or drink is an experience of this culture and have a lot of story to it.

“For example, making whiskey is a tradition native to Scotland, much like rum to the Caribbean, Mezcal to the Mexico and so on. These are parts of their values and teachings handed over from generation to generation, with much love and celebration, making it an intrinsic part of a living culture,” Prakash explained.

bottle
will also be a rite of passage for the new consumer who is open to experiencing luxury beverages that are a product of passion and commitment and are produced in small batches, without any compromise on quality. Pixabay

The event is open to only 400 aficionados each day.

“We envision two kinds of visitors at the Biennale – one who are newly immersing themselves in fine spirits and others who know their single malt, gin, whiskey etc. The aim is for the curated audience to meet curated brands and learn about their stories. We consciously wanted to create a small, well-curated festival that encourages such conversations amongst the visitors,” Prakash elaborated.

Also Read: The Unconventional Way of Learning: Textbooks Come Alive in Gujarat’s Schools
What will be on offer?

Over 50 handpicked fine beverage brands like Kilchoman Machir Bay, Rémy Martin, Cotswolds Gin, and Amrut Peated Port Pipe. Leading the audience will be mixologists from World’s 50 Best Bars, among them Hiroyasu Kayama of Tokyo, Alex Simonidis & Georgia Georgakopoulou of Athens and Jose Luis Leon of Mexico City. (IANS)