Saturday November 17, 2018

A Comprehensive Study Of Parasitic Worms Release Numerous Anwers

The analysis found almost a million new genes that had not been seen before, belonging to thousands of new gene families, and identified many new potential drug targets and drugs.

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parasitic Worm
A giant 25m worm representing the parasitic worm of schistosomiasis, that causes significant suffering and death to thousands of people around the world, is pictured on the Lake Leman on the occasion of the Neglected Tropical Diseases Summit, in Geneva, Switzerland. VOA
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The largest study to date of the genetic makeup of parasitic worms has found hundreds of new clues about how they invade the human body, evade its immune system and cause disease.

The results point to potential de-worming treatments to help fight some of the most neglected tropical diseases — including river blindness, schistosomiasis and hookworm disease — which affect around a billion people worldwide.

“Parasitic worms are some of our oldest foes and have evolved over millions of years to be expert manipulators of the human immune system,” said Makedonka Mitreva of Washington University’s McDonnell Genome Institute, who co-led the work with colleagues from Britain’s Wellcome Sanger Institute and Edinburgh University.

parasitic Worm
World’s longest tapeworm. wikimedia

She said the results of this study would lead to both a deeper knowledge of the biology of parasites and a better understanding of how human immune systems can be harnessed or controlled.

Parasitic worm infections can last many years and can cause severe pain, physical disabilities, retarded development in children and social stigma linked to deformity.

Current medicines to combat them — including drugs made by Sanofi, GSK and Johnson & Johnson — can be moderately effective and are often donated by drugmakers or sold at reduced prices to those who need them. But the spectrum of drugs to treat worm infections is still limited.

To try to improve the potential drug pipeline and to understand how worms invade and take up residence inside humans and other animals, the research team compared the genomes of 81 species of roundworms and flatworms, including 45 that had never previously had their genomes sequenced.

parasitic Worm
How gut microbiota can aid in early diagnosis of liver cancer.

The analysis found almost a million new genes that had not been seen before, belonging to thousands of new gene families, and identified many new potential drug targets and drugs.

Also Read: Genes Tied To Obesity May Lower Risk Of Diabetes

“We focused our search by looking at existing drugs for human illnesses,” said the Sanger Institute’s Avril Coghlan, who worked on the team. She said this offered a possible fast-track route “to pinpointing existing drugs that could be repurposed for deworming.”

The study’s findings were published Monday in the journal Nature Genetics. (VOA)

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Lack of Proper Sanitation Affects 620 Million Children Around The World: Report

Despite the improvements, more than a third of the girls in South Asia miss school for one to three days a month during their period.

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toilets, studentsac
A new toilet recently installed in a Rohingya refugee camp in Bangladesh. VOA

A lack of proper school toilets threatens the health, education and safety of at least 620 million children around the world, the charity WaterAid said in a new study published Friday.

Children at 1 in 3 schools lack access to proper toilets, putting them at risk of diarrhea and other infections and forcing some to miss lessons altogether, according to the study, based on data from 101 countries.

Guinea-Bissau in West Africa has the worst school toilets while Ethiopian children fare worst at home, with 93 percent of homes lacking a decent toilet according to the report, released ahead of World Toilet Day on Monday.

toilets, students
Students arrive for class at the Every Nation Academy private school in the city of Makeni in Sierra Leone, April 20, 2012. VOA

“The message here is that water and sanitation affect everything,” WaterAid spokeswoman Anna France-Williams told the Thomson Reuters Foundation. “If there’s no toilet in schools, children will miss lessons and it will have an impact on their growing up.”

Diarrhea, infection risk

A lack of proper sanitation puts millions of children around the world in danger of diarrhea, which kills 289,000 children younger than 5 a year, WaterAid said.

But some regions have started to clean up their act, notably South Asia, where access to toilets in schools has improved.

More than half the schools in Bangladesh now have access to decent toilets, while students in 73 percent of schools in India and 76 percent of those in Bhutan can access basic sanitation.

Akramul Islam, director of water, sanitation and hygiene at the Bangladeshi charity BRAC, said the country’s once-high levels of open defecation — using open ground rather than toilets — were now less than 1 percent.

toilets, studentsac
India’s plight in sanitation has not improved much since ages.
Pixabay

“Today, schools have separate toilets for girls and boys and the issue of menstrual hygiene is also being addressed,” he said. “This has happened because of initiatives taken by both the government, the NGOs and other stakeholders.”

Also Read: 3 HIV+ Students Banned From School in Indonesia

Improvement needed

Despite the improvements, more than a third of the girls in South Asia miss school for one to three days a month during their period, WaterAid said, urging greater investment in basic sanitation.

“If we are serious about all children and young people, wherever they are, whatever their gender, physical ability or community background, having their right to clean water and sanitation, we must take decisive and inclusive action now,” said Chief Executive Tim Wainwright. (VOA)