Thursday March 21, 2019

A Comprehensive Study Of Parasitic Worms Release Numerous Anwers

The analysis found almost a million new genes that had not been seen before, belonging to thousands of new gene families, and identified many new potential drug targets and drugs.

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parasitic Worm
A giant 25m worm representing the parasitic worm of schistosomiasis, that causes significant suffering and death to thousands of people around the world, is pictured on the Lake Leman on the occasion of the Neglected Tropical Diseases Summit, in Geneva, Switzerland. VOA

The largest study to date of the genetic makeup of parasitic worms has found hundreds of new clues about how they invade the human body, evade its immune system and cause disease.

The results point to potential de-worming treatments to help fight some of the most neglected tropical diseases — including river blindness, schistosomiasis and hookworm disease — which affect around a billion people worldwide.

“Parasitic worms are some of our oldest foes and have evolved over millions of years to be expert manipulators of the human immune system,” said Makedonka Mitreva of Washington University’s McDonnell Genome Institute, who co-led the work with colleagues from Britain’s Wellcome Sanger Institute and Edinburgh University.

parasitic Worm
World’s longest tapeworm. wikimedia

She said the results of this study would lead to both a deeper knowledge of the biology of parasites and a better understanding of how human immune systems can be harnessed or controlled.

Parasitic worm infections can last many years and can cause severe pain, physical disabilities, retarded development in children and social stigma linked to deformity.

Current medicines to combat them — including drugs made by Sanofi, GSK and Johnson & Johnson — can be moderately effective and are often donated by drugmakers or sold at reduced prices to those who need them. But the spectrum of drugs to treat worm infections is still limited.

To try to improve the potential drug pipeline and to understand how worms invade and take up residence inside humans and other animals, the research team compared the genomes of 81 species of roundworms and flatworms, including 45 that had never previously had their genomes sequenced.

parasitic Worm
How gut microbiota can aid in early diagnosis of liver cancer.

The analysis found almost a million new genes that had not been seen before, belonging to thousands of new gene families, and identified many new potential drug targets and drugs.

Also Read: Genes Tied To Obesity May Lower Risk Of Diabetes

“We focused our search by looking at existing drugs for human illnesses,” said the Sanger Institute’s Avril Coghlan, who worked on the team. She said this offered a possible fast-track route “to pinpointing existing drugs that could be repurposed for deworming.”

The study’s findings were published Monday in the journal Nature Genetics. (VOA)

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Beware! Sipping Hot Tea Raises Risk of Esophageal Cancer

Esophageal cancer is the sixth most common cancer in India and eighth most globally. It affects more men than women.

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Scalding water irritates the lining of the mouth and throat which can fuel tumours, scientists believe. Pixabay

Love to drink your tea piping hot? Beware, it could raise the risk of esophageal cancer, finds a study.

The study showed that risk of esophageal cancer more than doubled among those who regularly drank tea at 75 degrees Celsius

However, waiting for at least four minutes before drinking a cup of freshly boiled tea can reduce the risk of the cancer arising from the oesophagus — the food pipe that runs between the throat and the stomach.

“Many people enjoy drinking tea, coffee, or other hot beverages. However, according to our report, drinking very hot tea can increase the risk of esophageal cancer, and it is therefore advisable to wait until hot beverages cool down before drinking,” said lead author Farhad Islami of the American Cancer Society.

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The study showed that risk of esophageal cancer more than doubled among those who regularly drank tea at 75 degrees Celsius. Pixabay

The study, published in the International Journal of Cancer, involved 50,045 individuals aged 40 to 75 years.

Drinking 700 ml per day of tea or more at a higher temperature (60 degrees Celsius or higher) was associated with a 90 per cent higher risk of esophageal cancer, the researchers said.

The results could also be extended to coffee, hot chocolate or other hot beverages.

Esophageal cancer is the sixth most common cancer in India and eighth most globally. It affects more men than women.

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The results could also be extended to coffee, hot chocolate or other hot beverages. pixabay

Also Read: All New Gaming Platform! Google Launches Cloud Gaming Service Stadia
In 2016, the World Health Organisation (WHO) had warned of the cancer risk associated with drinks above 65 degrees Celsius.

Scalding water irritates the lining of the mouth and throat which can fuel tumours, scientists believe. (IANS)