Saturday December 7, 2019

Additives in E-Cigarettes Impair Lung Functioning

However, respiratory mechanics were adversely affected only in mice exposed to cigarette smoke and not to e-cigarette vapour after prolonged treatment

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E-cigarette additives impair lung function: Study.

Flavouring and additive ingredients used in e-cigarettes are more likely to increase inflammation and impair lung function, according to new research.

E-cigarettes — popular battery-powered devices that simulate the act of smoking a traditional cigarette — dispense a vapour derived from liquid chemicals in a refillable cartridge.

Researchers from the University of Athens found that short-term exposure to e-cigarettes was enough to cause lung inflammation similar or worse than that seen in traditional cigarette use.

The study, published in the American Journal of Physiology – Lung Cellular and Molecular Physiology, examined several groups of mice that received whole-body exposure to varying chemical combinations four times each day.

Each exposure session was separated by 30-minute smoke-free intervals.

One group was exposed to cigarette smoke, another with e-cigarette vapour containing propylene glycol and vegetable glycerol — an odourless liquid derived from plant oils, the third with e-cigarette vapour containing propylene glycol and nicotine and another group was exposed to e-cigarette vapour containing propylene glycol, nicotine and tobacco flavouring.

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In this April 11, 2018, photo, an unidentified 15-year-old high school student uses a vaping device near the school’s campus in Cambridge, Mass. Health and education officials across the country are raising alarms over wide underage use of e-cigarettes and other vaping products. The devices heat liquid into an inhalable vapor that’s sold in sugary flavors like mango and mint — and often with the addictive drug nicotine. VOA

The findings suggested an increase in markers of inflammation, mucus production and altered lung function in the propylene, propylene plus nicotine and flavouring groups after three days.

In addition, two inflammation-producing proteins became elevated only in the flavouring group, which suggested that some flavouring components on the market may not be safe for even short-term use.

The level of oxidative stress — stress at a cellular level — in the flavouring group was equal to or higher than that of the cigarette group.

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However, respiratory mechanics were adversely affected only in mice exposed to cigarette smoke and not to e-cigarette vapour after prolonged treatment.

“The observed detrimental effects in the lung upon (e-cigarette) vapour exposure in animal models highlight the need for further investigation of safety and toxicity of these rapidly expanding devices worldwide,” the researchers warned. (IANS)

Next Story

Indian Parliament Imposes Ban on E-Cigarettes

Moving the Bill, Harsh Vardhan clarified that e-cigarettes are not tobacco products

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E-Cigarettes
E-cigarettes are electronic devices which can enable the delivery of all intoxicating substances. Predominantly, they are used for nicotine delivery, which is one of the most addictive elements known. Pixabay

Paving the way for a complete ban on E-Cigarettes, the Rajya Sabha on Monday passed the Prohibition of E-Cigarettes (Production, Manufacture, Import, Export, Transport, Sale, Distribution, Storage and Advertisement) Bill, 2019, by voice vote.

The Bill has already been passed by the Lok Sabha for replacing the ordinance promulgated last September.

Replying to members on the Bill, Union Health Minister Harsh Vardhan urged them to pass the legislation unanimously in the larger interest of the children.

“There is evidence now that e-cigarettes are very harmful. They can become a bigger menace than tobacco one day. So, the intention of the government has been to nip the problem in the bud itself,” the minister said.

While most members in the House supported the ban on e-cigarettes, some of the MPs wanted to know why conventional cigarettes aren’t banned as they are equally or even more harmful.

Many opposition members also expressed reservation over bringing the ordinance and introducing the Bill without sending the same to a Parliamentary Standing Committee.

On why all tobacco products are not being banned, Harsh Vardhan said that he would be the happiest person if that happens.

“You see, in a country as vast as India, once a particular product has a very big consumer base and social acceptance, it is in fact very, very difficult to ban it,” the minister said.

On the reasons for bringing the ordinance, the minister said that apart from other things, some of the big tobacco companies changed their names and started making plans to enter India.

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Paving the way for a complete ban on E-Cigarettes, the Rajya Sabha on Monday passed the Prohibition of Electronic Cigarettes (Production, Manufacture, Import, Export, Transport, Sale, Distribution, Storage and Advertisement) Bill, 2019, by voice vote. Wikimedia Commons

“They had made full preparations. There was an announced entry of a company called Juul, one of the leading global manufacturers of e-cigarettes, in December 2019. It was probably one of the most imminent concerns that worried all of us,” he said.

Participating in the discussions, Trinamool Congress leader Santanu Sen argued for banning all tobacco products as all of them were harmful to human health.

“Of course, by this Bill we are preventing a person from committing suicide by jumping from the fifth floor, but we are also keeping the more affordable and accessible 10th floor wide open to jump from,” Sen said to highlight the serious health concerns posed by conventional cigarettes.

The Rajya Sabha MP, also national president of Indian Medical Association, noted that a normal cigarette constitutes 700 chemicals out of which 250 are very much harmful. Further, out of this 250 chemicals, 60 cause cancer while all of them are carcinogenic.

“Smoking increases coronary heart disease by 2 to 4 times. It increases stroke by 2 to 4 times. It increases lung cancer by 25 times and it increases the probability of COPDA (Chronic Obstructive Pulmonary Disease) by 13 times,” the Trinamool leader said.

Congress MP B.K. Hariprasad said that he did not support e-cigarettes but opposed the way the Bill had been brought. He also suspected the intention of the government behind bringing the ordinance and subsequently the Bill hurriedly.

“People are smelling a rat in the way this Bill has been brought hastily,” Hariprasad said while making a case for banning all tobacco products as all of them were equally harmful.

He said the government should not succumb to tobacco lobbyists.

Senior CPI leader Binoy Viswam also raised questions around the manner in which the bill had been introduced as no survey or study was carried out before bringing the legislation.

Replying to members on the Bill, Harsh Vardhan said that all his life he had fought against tobacco lobbyists and therefore members should not have any suspicion on his intention.

Congress MP Rajeev Gowda said that the ban has to be a last resort rather than the first resort which is what has been the practice in this particular context.

“A ban or prohibition, as we have seen everywhere, results in underground activities. It results in criminalisation of the society. It results in the creation of a mafia that deals with the underground activity,” Gowda said while participating in the discussions on the bill.

E-cigarettes are electronic devices which can enable the delivery of all intoxicating substances. Predominantly, they are used for nicotine delivery, which is one of the most addictive elements known. This also includes all forms of electronic nicotine as well as non-nicotine delivery devices such as e-hookahs and heat-not-burn products.

Moving the Bill, Harsh Vardhan clarified that e-cigarettes are not tobacco products.

“Any comparison about their adverse health impacts with tobacco is misplaced. There is also no conclusive evidence to suggest that e-cigarettes are less harmful than conventional cigarettes. On the other hand, there is definitely an emerging evidence all over the world that e-cigarettes have significantly harmful effects on health,” the minister said.

E-Cigarettes
The Rajya Sabha MP, also national president of Indian Medical Association, noted that Apart From E-Cigarettes, a normal cigarette constitutes 700 chemicals out of which 250 are very much harmful. Further, out of this 250 chemicals, 60 cause cancer while all of them are carcinogenic. Pixabay

Highlighting the harmful effects of nicotine delivered by e-cigarettes, the minister said that nicotine sulfate was once approved to be used as a pesticide by the agriculture department.

“Recently, even that approval has been withdrawn considering its toxicity. Therefore, it is a chemical that is not even fit to be used as a pesticide. That is the latest about nicotine.

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“It is the most addictive substance currently known in the world and is even more addictive than heroin. There is currently no known treatment for nicotine-addiction anywhere in the world,” Harsh Vardhan said. (IANS)