Sunday September 22, 2019

Additives in E-Cigarettes Impair Lung Functioning

However, respiratory mechanics were adversely affected only in mice exposed to cigarette smoke and not to e-cigarette vapour after prolonged treatment

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e-cigarette
E-cigarette additives impair lung function: Study.

Flavouring and additive ingredients used in e-cigarettes are more likely to increase inflammation and impair lung function, according to new research.

E-cigarettes — popular battery-powered devices that simulate the act of smoking a traditional cigarette — dispense a vapour derived from liquid chemicals in a refillable cartridge.

Researchers from the University of Athens found that short-term exposure to e-cigarettes was enough to cause lung inflammation similar or worse than that seen in traditional cigarette use.

The study, published in the American Journal of Physiology – Lung Cellular and Molecular Physiology, examined several groups of mice that received whole-body exposure to varying chemical combinations four times each day.

Each exposure session was separated by 30-minute smoke-free intervals.

One group was exposed to cigarette smoke, another with e-cigarette vapour containing propylene glycol and vegetable glycerol — an odourless liquid derived from plant oils, the third with e-cigarette vapour containing propylene glycol and nicotine and another group was exposed to e-cigarette vapour containing propylene glycol, nicotine and tobacco flavouring.

e-cigarettes
In this April 11, 2018, photo, an unidentified 15-year-old high school student uses a vaping device near the school’s campus in Cambridge, Mass. Health and education officials across the country are raising alarms over wide underage use of e-cigarettes and other vaping products. The devices heat liquid into an inhalable vapor that’s sold in sugary flavors like mango and mint — and often with the addictive drug nicotine. VOA

The findings suggested an increase in markers of inflammation, mucus production and altered lung function in the propylene, propylene plus nicotine and flavouring groups after three days.

In addition, two inflammation-producing proteins became elevated only in the flavouring group, which suggested that some flavouring components on the market may not be safe for even short-term use.

The level of oxidative stress — stress at a cellular level — in the flavouring group was equal to or higher than that of the cigarette group.

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However, respiratory mechanics were adversely affected only in mice exposed to cigarette smoke and not to e-cigarette vapour after prolonged treatment.

“The observed detrimental effects in the lung upon (e-cigarette) vapour exposure in animal models highlight the need for further investigation of safety and toxicity of these rapidly expanding devices worldwide,” the researchers warned. (IANS)

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Certain Flavoured E-Cigarettes Worsen Severity of Diseases Such as Asthma

This is especially important for those with respiratory disease, whom are vulnerable to the effects of smoking

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Flavoured, E-Cigarettes, Diseases
Certain flavoured e-cigarettes, even without nicotine, may change how airways, affected by an allergic disease, function, thus worsening the severity of diseases such as asthma, say researchers. Pixabay

Certain flavoured e-cigarettes, even without nicotine, may change how airways, affected by an allergic disease, function, thus worsening the severity of diseases such as asthma, say researchers.

For the first time, a model of asthma was used to investigate the effect of a range of popular e-cigarette flavours, with and without nicotine.

“This is especially important for those with respiratory disease, whom are vulnerable to the effects of smoking,” Dr Chapman said.

“The majority of e-cigarette smokers use flavoured liquids but there is some evidence that flavour additives can be toxic when inhaled,” said Dr David Chapman from from the University of Technology Sydney (UTS).

Flavoured, E-Cigarettes, Diseases
Certain flavoured e-cigarettes, even without nicotine, may change how airways, affected by an allergic disease, function, thus worsening the severity of diseases such as asthma, say researchers. Pixabay

The use of e-cigarettes has dramatically increased in the past few years, especially among younger smokers globally.

Despite the suggestion they are a healthier alternative to tobacco cigarettes, there is a lack of evidence in both animal studies and human data on the effect of e-cigarettes on lung function.

The researchers found that some flavoured e-cigarettes, even in the absence of nicotine, can worsen disease severity.

“The exact effects on features of asthma were dependent upon the specific flavour, suggesting not all flavoured e-cigarettes will have the same consequences on lung health,” Dr Chapman said in the study published in Scientific Reports.

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In this study, the flavour Black Licorice exaggerated airway inflammation whereas Cinnacide had the opposite effect, suppressing airway inflammation.

The researchers didn’t analyse the liquids directly, to confirm what they contained, however there is evidence from previous research that flavours categorised as “buttery/creamy” and “cinnamon”, which likely include “Banana Pudding” and “Cinnacide”, respectively, are toxic.

Caution should be taken in promoting the use of flavoured e-cigarettes to patients with respiratory disease such as asthma and that policy makers should consider restricting the use of flavoured e-cigarettes, the team added. (IANS)