Wednesday March 20, 2019

Additives in E-Cigarettes Impair Lung Functioning

However, respiratory mechanics were adversely affected only in mice exposed to cigarette smoke and not to e-cigarette vapour after prolonged treatment

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e-cigarette
E-cigarette additives impair lung function: Study.

Flavouring and additive ingredients used in e-cigarettes are more likely to increase inflammation and impair lung function, according to new research.

E-cigarettes — popular battery-powered devices that simulate the act of smoking a traditional cigarette — dispense a vapour derived from liquid chemicals in a refillable cartridge.

Researchers from the University of Athens found that short-term exposure to e-cigarettes was enough to cause lung inflammation similar or worse than that seen in traditional cigarette use.

The study, published in the American Journal of Physiology – Lung Cellular and Molecular Physiology, examined several groups of mice that received whole-body exposure to varying chemical combinations four times each day.

Each exposure session was separated by 30-minute smoke-free intervals.

One group was exposed to cigarette smoke, another with e-cigarette vapour containing propylene glycol and vegetable glycerol — an odourless liquid derived from plant oils, the third with e-cigarette vapour containing propylene glycol and nicotine and another group was exposed to e-cigarette vapour containing propylene glycol, nicotine and tobacco flavouring.

e-cigarettes
In this April 11, 2018, photo, an unidentified 15-year-old high school student uses a vaping device near the school’s campus in Cambridge, Mass. Health and education officials across the country are raising alarms over wide underage use of e-cigarettes and other vaping products. The devices heat liquid into an inhalable vapor that’s sold in sugary flavors like mango and mint — and often with the addictive drug nicotine. VOA

The findings suggested an increase in markers of inflammation, mucus production and altered lung function in the propylene, propylene plus nicotine and flavouring groups after three days.

In addition, two inflammation-producing proteins became elevated only in the flavouring group, which suggested that some flavouring components on the market may not be safe for even short-term use.

The level of oxidative stress — stress at a cellular level — in the flavouring group was equal to or higher than that of the cigarette group.

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However, respiratory mechanics were adversely affected only in mice exposed to cigarette smoke and not to e-cigarette vapour after prolonged treatment.

“The observed detrimental effects in the lung upon (e-cigarette) vapour exposure in animal models highlight the need for further investigation of safety and toxicity of these rapidly expanding devices worldwide,” the researchers warned. (IANS)

Next Story

FDA Proposes to Curb Sales of Flavoured E-cigarettes to Teenagers

The health regulator also proposed pre-market applications for all flavoured e-cigarette products that continue to be sold by August 8, 2021

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e-cigarette, vaping
In this April 11, 2018, photo, an unidentified 15-year-old high school student uses a vaping device near the school's campus in Cambridge, Mass. Health and education officials across the country are raising alarms over wide underage use of e-cigarettes and other vaping products. The devices heat liquid into an inhalable vapor that's sold in sugary flavors like mango and mint — and often with the addictive drug nicotine. VOA

The US Food and Drug Administration (FDA) has proposed to curb sales of flavoured e-cigarettes to teenagers.

The health regulator on Wednesday said that it is proposing to end all flavoured electronic nicotine delivery system (ENDS) products such as electronic cigarettes, except tobacco, mint and menthol-flavoured products.

According to the Centers for Disease Control and Prevention, a total of 3.6 million middle and high school students reported using e-cigarettes last year.

“Evidence shows that youth are especially attracted to flavoured e-cigarette products, and that minors are able to access these products from both brick-and-mortar retailers, as well as online, despite federal restrictions on sales to anyone under 18,” FDA Commissioner Scott Gottlieb, said in a statement.

“With these concerns in mind, today, we’re advancing our policies aimed at preventing youth access to, and appeal of, flavoured e-cigarettes and cigars.”

E-cigarettes, Smokers
Talia Eisenberg, co-founder of the Henley Vaporium, uses her vaping device in New York, Feb. 20, 2014. VOA

The new proposed policy also subjects all manufacturers and retailers to FDA enforcement for selling certain flavoured ENDS products without authorisation.

The FDA had previously threatened to ban most flavoured e-cigarettes in 2017 but did not take any enforcement moves.

However, with the new policy, FDA intends to prioritise its enforcement to focus on protecting youth from becoming addicted to nicotine.

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It believes, at the same time, “that ENDS products still hold promise to help transition currently addicted adult smokers to potentially less harmful sources of nicotine”, Gottlieb said.

The health regulator also proposed pre-market applications for all flavoured e-cigarette products that continue to be sold by August 8, 2021. (IANS)